Clinical-Pathologic Response Discordance After Neoadjuvant Therapy in Rectal Cancer and Its Prognostic Implications [0.03%]
Aysun Arslantas Erken,Selvi Tabak Dincer
Aysun Arslantas Erken
Aims: The prognostic value of clinical complete/near-complete response (cCR/near-cCR) relative to pathologic complete/near-complete response (pCR/near-pCR) after neoadjuvant therapy for locally advanced rectal cancer (LAR...
Real-World Outcomes of Total Neoadjuvant Therapy Versus Standard Neoadjuvant Chemoradiotherapy in Stage II-III Locally Advanced Rectal Cancer: A Comparative Cohort Study [0.03%]
全程新辅助治疗与常规新辅助放化疗在II-III期局部晚期直肠癌中的真实世界疗效比较：一项队列研究
Aysun Arslantas Erken,Selvi Tabak Dincer
Aysun Arslantas Erken
Aim: Total neoadjuvant therapy has been adopted to improve systemic disease control in locally advanced rectal cancer, yet long-term real-world outcomes, particularly in non-Western populations, remain incompletely define...
Myeloablative Busulfan, Fludarabine and Melphalan Conditioning for Allogeneic Hematopoietic Stem Cell Transplantation in Childhood Myeloid Malignancy [0.03%]
用于儿童髓系恶性肿瘤异基因造血干细胞移植的清髓性_busulfan，氟达拉滨和美法仑预处理方案
Mayank Dhamija,Fiona Kerr,Hazel Gough et al.
Mayank Dhamija et al.
Background: Allogeneic hematopoietic stem cell transplant (HSCT) is a proven curative therapy for children with high-risk myeloid malignancies. Disease relapse, transplant-related mortality and graft versus host disease (...
Biomarker-Guided Inflammatory Control and Multidimensional Recovery After Abdominoperineal Resection: A Prospective Cohort Study [0.03%]
基于生物标志物指导的术后炎症控制及多维度康复在腹会阴直肠癌根治术围手术期应用的前瞻性队列研究
Shengjie Pan,Gang Wang
Shengjie Pan
Background: Patients undergoing abdominoperineal resection (APR) for rectal cancer frequently experience persistent inflammation, nutritional decline, and psychosocial distress, which may adversely affect postoperative re...
Analysis of Clinical Factors Impacting Imatinib Trough Concentrations in Chinese Patients With Gastrointestinal Stromal Tumors: A Real-World Study [0.03%]
中国胃肠间质瘤患者伊马替尼谷浓度影响因素分析：一项真实世界研究
Cui Tang,Jinxing Huang,Jiadan Yang et al.
Cui Tang et al.
Background: Imatinib mesylate (IM) is the first-line treatment for gastrointestinal stromal tumors (GISTs) and significantly improves patient outcomes. However, high inter-patient variability in imatinib plasma exposure l...
Safety and Efficacy of Radiotherapy Plus Immunotherapy in Advanced Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis [0.03%]
放射治疗联合免疫治疗用于晚期肝细胞癌的安全性和有效性的系统评价和 meta 分析
Hasnain Wajeeh Saqib,Mustafa Iqbal Khan,Tazeem Hayat et al.
Hasnain Wajeeh Saqib et al.
Background: The role of combining radiotherapy (RT) with immune checkpoint inhibitors (ICIs) in advanced hepatocellular carcinoma (HCC) remains unclear. We aimed to evaluate the efficacy and safety of RT plus ICI compared...
Endosomal Entrapment: The Silent Failure Point of Cancer Nanotherapeutics and How Pharmaceutical Design Can Overcome It [0.03%]
癌纳米治疗中的内涵体陷阱及如何通过药物设计克服它
Rajesh Gautam,Dilpreet Singh
Rajesh Gautam
Cancer nanotherapeutics have demonstrated remarkable potential in improving drug solubility, targeting specificity, and pharmacokinetics; however, their clinical translation has remained disproportionately limited. A major yet insufficientl...
Clinical Outcomes of the POPCORN Study: Pharmacodynamics of Pre-Operative PD1 CheckpOint Blockade and Receptor Activator of NF-κB Ligand (RANKL) Inhibition in Non-Small Cell Lung Cancer (NSCLC)-A Phase 1B/2 Trial [0.03%]
POPCORN研究的临床结果：非小细胞肺癌（NSCLC）新辅助PD1检查点抑制剂和核因子-κB受体活化配体（RANKL）抑制剂的药代动力学：一项Ib/II期临床试验
Elizabeth Ahern,Cassie Turner,Rishendran Naidoo et al.
Elizabeth Ahern et al.
Background: There is a growing body of evidence supporting neoadjuvant systemic therapy to improve outcomes for people with early-stage non-small cell lung cancer (NSCLC). However, not all patients will respond, necessita...
Palbociclib in the Treatment of HR+/ HER2- Advanced or Metastatic Breast Cancer in Australia: A Real-World Retrospective Analysis [0.03%]
帕博西尼在澳大利亚HR+/HER2-晚期或转移性乳腺癌患者治疗中的应用：一项真实世界回顾性研究
Louise Nott,Eugene Moylan,Maree Colosimo et al.
Louise Nott et al.
Background: There is limited real-world data on the use of CDK4/6 inhibitors in Australian patients with HR+/HER2- advanced or metastatic breast cancer. This study describes the demographic and clinical characteristics of...
Lipid Metabolism and Oxidative Stress in Uterine Corpus Endometrial Carcinoma: Prognostic and Immune Landscape Analysis [0.03%]
子宫体子宫内膜癌中的脂质代谢和氧化应激：预后和免疫图谱分析
Hongfeng Li,Jia Bian,Qinwei Zhang et al.
Hongfeng Li et al.
Objective: Uterine corpus endometrial carcinoma (UCEC) is a common gynecologic malignancy characterized by metabolic reprogramming and immune dysregulation. This study aimed to investigate the prognostic and diagnostic va...