Integrated human-relevant NAMs for biomedical evaluation of selenium nanoparticles linking epithelial barrier translocation to neuronal effects [0.03%]
集成了人类相关NAMS的硒纳米颗粒生物医学评价体系将上皮屏障转运与神经效应联系起来
Ivan Mamić,Pamina Weber,Maja Beus et al.
Ivan Mamić et al.
New Approach Methodologies (NAMs) are increasingly needed to evaluate the safety and efficacy of nanomaterials in biomedicine while generating human-relevant evidence and reducing reliance on animal studies. For therapeutic nanoformulations...
Benefits, risks, and future prospectives of nanomaterials in sustainable agriculture: a review [0.03%]
纳米材料在可持续农业中的利弊及前景：综述
Niharika Pandey,Diksha Sharma,Aayeisha Das et al.
Niharika Pandey et al.
Modern agriculture is under increasing pressure to meet the food demands of a growing global population while reducing the environmental and health impacts associated with intensive chemical inputs. This study aims to evaluate the role of n...
Decoding silica nanoparticle toxicity: integrating machine learning, feature importance, rule extraction, and adsorption-uptake processes [0.03%]
二氧化硅纳米粒子毒性的解码：结合机器学习、特征重要性、规则提取和吸附摄取过程
Roni Romano,Alexander Barbul,Rafi Korenstein
Roni Romano
The complexity of nanoparticle toxicity necessitates applying machine learning to large toxicological datasets to identify predictive features and toxicity rules. This study investigates the relationships between the physicochemical propert...
Polystyrene nanoparticles and death of erythrocytes: does exposure induce eryptosis? [0.03%]
聚苯乙烯纳米微粒和红细胞的凋亡：暴露是否诱发红细胞凋亡？
Kamil Płuciennik,Bożena Bukowska,Paulina Sicińska
Kamil Płuciennik
The widespread presence of polystyrene nanoparticles (PS-NPs) in the human body has raised concerns about their potential biological toxicity. When assessing the safety of nanoparticles and other xenobiotics, a key aspect is their effect on...
Polystyrene nanoplastics promote tumor lung metastasis by inducing sodium overload in macrophages in an NMDAR-dependent way [0.03%]
聚苯乙烯纳米塑料通过诱导巨噬细胞中的钠超载以N-甲基-D天冬氨酸受体依赖性的方式促进肿瘤肺转移
Lin Li,Zeyan Li,Na Ji et al.
Lin Li et al.
Micro- and nanoplastics (MNPs) are increasingly recognized as ubiquitous environmental pollutants; however, their role in tumor metastasis remains poorly understood. This study aimed to investigate the impact of polystyrene nanoplastics on ...
Comparative entomotoxic effects of nanosilica and microsilica on Crocidolomia pavonana larvae [0.03%]
纳米硅石和微硅石对斑马菜青虫的比较毒理效应研究
Melanie Melanie,Shofi Afiya Syahbani,Wawan Hermawan et al.
Melanie Melanie et al.
Nanosilica represents a promising material for insect pest management. This study compared the physicochemical properties and entomotoxic effects of nanosilica and microsilica powders against Crocidolomia pavonana larvae. The X-Ray-Fluoresc...
Gold-modified superparamagnetic iron oxide nanoparticles: Magnetic accumulation under flow conditions and toxicity evaluation in vitro and in vivo [0.03%]
表面改性的金磁纳米颗粒的体外及体内毒性研究及其在流动条件下的聚集行为研究
Hatice Genç,René Stein,Andreas Ettner-Sitter et al.
Hatice Genç et al.
Superparamagnetic iron oxide nanoparticles (SPIONs) enable enhanced magnetic drug targeting and theranostic applications. This study investigated potential toxic effects of SPIONs developed for drug delivery applications. Gold-modified SPIO...
Pd@CeO2 core-shell heteronanostructures with enhanced multienzyme activity for macrophage polarization and in flammation alleviation [0.03%]
用于巨噬细胞极化和抗炎的具有多酶活性的Pd@CeO2 核壳杂纳米结构
Yanting Zhan,Yiyang Wu,Chanting Huang et al.
Yanting Zhan et al.
The high expression of classically activated macrophages (M1) subtypes and the elevated levels of reactive oxygen species (ROS) are specifically observed in osteoarthritis (OA) patients. In this study, we synthesized a Pd@CeO2 nanozyme with...
Managing uncertainties in risk assessment of activities involving nanomaterials: the case of control banding-based methodologies [0.03%]
纳米材料相关活动的风险评估中的不确定性管理：基于防护带法的方法学案例分析
Soqrat Omari Shekaftik,Abbas Sheikhtaheri,Somayeh Farhang Dehghan et al.
Soqrat Omari Shekaftik et al.
The risk assessment of Engineered Nanomaterials takes place under continuous conditions of data scarcity, mainly induced by the fast-paced development of new materials and the absence of sufficient toxicological and exposure data. Control b...
Application of small molecule inhibitors to probe the mechanism underlying nanomaterial pulmonary inflammatory responses in vitro [0.03%]
小分子抑制剂在探究纳米材料体外肺炎症响应机制中的应用研究
Morgan Lofty,David M Brown,Beatriz Vale de Melo E Oliveira McDermott et al.
Morgan Lofty et al.
Evidence shows that nanomaterial (NM)-induced pro-inflammatory cytokine production is regulated via redox-sensitive transcription factors (TFs). However, there is limited information regarding the intracellular signaling pathways that regul...