As the virus evolves, so too must we: a drug developer's perspective : We need a new paradigm in searching for next-generation countermeasures [0.03%]
病毒在进化，我们也必须随之改变：一个药物开发者对下一代对策研发的看法
Fang Flora Fang
Fang Flora Fang
The SARS-CoV-2 virus has been raging globally for over 2 years with no end in sight. It has become clear that this virus possesses enormous genetic plasticity, and it will not be eradicated. Under increasing selective pressure from populati...
Gaber El-Saber Batiha,Hayder M Al-Kuraishy,Ali I Al-Gareeb et al.
Gaber El-Saber Batiha et al.
Most COVID-19 patients recovered with low mortality; however, some patients experienced long-term symptoms described as "long-COVID" or "Post-COVID syndrome" (PCS). Patients may have persisting symptoms for weeks after acute SARS-CoV-2 infe...
Whole-genome analysis of human papillomavirus 67 isolated from Japanese women with cervical lesions [0.03%]
来自日本宫颈病变患者的完整基因组分析的人乳头瘤病毒67型
Gota Kogure,Mamiko Onuki,Yusuke Hirose et al.
Gota Kogure et al.
Background: Human papillomavirus (HPV) type 67 is phylogenetically classified into Alphapapillomavirus species 9 (alpha-9) together with other carcinogenic types (HPV16, 31, 33, 35, 52 and 58), but is the only alpha-9 typ...
Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infection [0.03%]
轻症与重症COVID-19感染者三聚体动机蛋白28表达水平比较分析
Rezvan Tavakoli,Pooneh Rahimi,Mojtaba Hamidi-Fard et al.
Rezvan Tavakoli et al.
Background: Tripartite motif-containing 28 (TRIM28) is an impressive regulator of the epigenetic control of the antiviral immune response. This study evaluated if the differential expression of TRIM28 correlates with the ...
A fatal case of viral sepsis and encephalitis in a child caused by human adenovirus type 7 infection [0.03%]
一例严重感染 VII 型人腺病毒的儿童败血症和脑炎死亡病例报告
Hongwei Zhao,Yingchao Liu,Ziheng Feng et al.
Hongwei Zhao et al.
Adenoviruses are highly prevalent pathogens responsible for a wide range of clinical diseases, including respiratory tract infection, acute gastroenteritis, and conjunctivitis. However, adenovirus infection is rarely associated with central...
Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence [0.03%]
巨细胞病毒感染可能具有抑癌作用：单中心经验和全球证据调查结果显示其可对抗B淋巴细胞性肿瘤
Marko Janković,Aleksandra Knežević,Milena Todorović et al.
Marko Janković et al.
Background: Although cytomegalovirus (CMV) is not considered tumorigenic, there is evidence for its oncomodulatory effects and association with hematological neoplasms. Conversely, a number of experimental and clinical st...
Traces of JC polyomavirus in papillary thyroid cancer: a comprehensive study in Iran [0.03%]
JC多瘤病毒蛋白在乳头状甲状腺癌中的表达：伊朗的综合研究
Amir Ali Karimi,Rahil Tarharoudi,Zahra Kianmehr et al.
Amir Ali Karimi et al.
Background: JC polyomavirus (JCPyV) is known to induce solid tumors such as astrocytomas, glioblastomas, and neuroblastomas in experimental animals, and recent studies have shown that the virus may be correlated with carc...
Alaa Bedair,Kamal Okasha,Fotouh R Mansour
Alaa Bedair
The coronavirus pandemic is a worldwide hazard that poses a threat to millions of individuals throughout the world. This pandemic is caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), which was initially identified ...
Ming Zhong,Huiqiang Wang,Haiyan Yan et al.
Ming Zhong et al.
Background: β-Amyloid (Aβ) protein is a pivotal pathogenetic factor in Alzheimer's disease (AD). However, increasing evidence suggests that the brain has to continuously produce excessive Aβ to efficaciously prevent pa...
Ultrasensitive and visual detection of human norovirus genotype GII.4 or GII.17 using CRISPR-Cas12a assay [0.03%]
利用CRISPR-Cas12a检测人类诺如病毒GII.4或GII.17基因型的超灵敏可视化方法
Weidong Qian,Jie Huang,Ting Wang et al.
Weidong Qian et al.
Background: Integrating CRISPR-Cas12a sensors with isothermal signal amplification can be exploited to develop low-cost, disposable, and ultrasensitive assays for the diagnostics of human pathogens. ...