Full genome sequencing, evolutionary dynamics, and pathogenicity evaluation of chicken infectious anemia virus with emphasis on Upper Egypt reveals genetic variability linked to vaccinal strains [0.03%]
基于埃及地区鸡贫血病毒全基因组的进化和致病性分析揭示与疫苗株相关的遗传变异
Eman Abd Elmenum Shosha,Ibrahim Eldaghayes,Ali Mahmoud Zanaty et al.
Eman Abd Elmenum Shosha et al.
Despite intensive vaccination efforts, Chicken Infectious Anemia Virus (CIAV) remains a formidable threat to the Egyptian poultry industry, primarily through the emergence of vaccine-escape variants. While most studies have focused on North...
A dried blood spot protocol for high-throughput semi-quantitative analysis of Epstein-Barr Virus VCA IgG and EBNA IgG serologies based on the Roche Elecsys system [0.03%]
基于罗氏埃莱克斯系统针对Epstein-Barr病毒VCA IgG和EBNA IgG的高通量半定量检测的干血斑协议
Raquel Rubio-Acero,Christina Reinkemeyer,Mona Niethammer et al.
Raquel Rubio-Acero et al.
Background: Epstein-Barr virus (EBV) is highly prevalent worldwide and has been linked to different cancers and autoimmune disorders, including Multiple sclerosis (MS). Primary infection typically occurs during early chil...
NGS-diagnosed HBV encephalitis with isolated left parietal lobe involvement: a case report [0.03%]
一项有关HBV脑炎且仅累及左侧顶叶的病例报告
Zihan Zhou,Zhangning Zhou,Longqi Zhang
Zihan Zhou
Background: Viral encephalitis refers to the inflammation of the brain parenchyma caused by viral infection, usually manifested as fever, unconsciousness, seizures, and meningeal irritation symptoms. The non-specific clin...
Generation and immunological evaluation of SARS-CoV-2 membrane protein virus-like particles [0.03%]
SARS-CoV-2膜蛋白病毒样颗粒的生成及免疫学评价
Akash Kumar,Krishna Kishore Inampudi,Vikas Kumar et al.
Akash Kumar et al.
Background: The emergence of the SARS-CoV-2 pandemic led to the spread of highly transmissible variants, such as the Delta variant, which originated in India, underscoring the urgent need to develop new antivirals, therap...
Exploration of viral diversity in Aedes mosquitoes employing different shotgun metagenomic data analysis pipelines [0.03%]
基于不同鸟枪法元基因组数据的病毒多样性分析方法对蚊虫病毒多样性的研究
Ekta Gupta,Shashi Sharma,Sachin Narayan Tikar et al.
Ekta Gupta et al.
Metagenomics or metaviromics is emerging as a powerful technology for pathogen surveillance and pandemic preparedness. Mosquitoes are important vectors for transmission of many emerging viruses responsible for numerous outbreaks. Monitoring...
RRM2B is associated with low-level viremia during entecavir therapy in pediatric chronic hepatitis B and promotes profibrotic signaling in vitro [0.03%]
乙醚治疗对儿童慢性乙肝患者的影响与促进体内促纤维化信号传导有关
Yuanzhen Zhang,Aoxue Tan,Tingting Wu et al.
Yuanzhen Zhang et al.
Background: Low-level viremia (LLV) during nucleos(t)ide analogue therapy for chronic hepatitis B (CHB) is clinically relevant, but its biological basis in children remains unclear. We investigated the clinical features o...
Major protease inhibitor drug resistance mutations among patients with virological failure on second-line antiretroviral therapy in Zimbabwe: a retrospective cross-sectional study [0.03%]
津巴布韦二线抗逆转录病毒治疗后病毒学失败患者的的主要蛋白酶抑制剂耐药突变：一项回顾性横断面研究
Justin Mayini,Tendai Washaya,Justen Manasa et al.
Justin Mayini et al.
Background: Virological failure (VF) on protease inhibitor (PI)-based second-line antiretroviral therapy (ART) remains an important driver of HIV drug resistance (HIVDR) in sub-Saharan Africa. Despite widespread adoption ...
A highly sensitive amplicon sequencing workflow for genomic surveillance of Usutu virus [0.03%]
一种用于乌苏图病毒基因组监测的高度敏感的扩增子测序工作流程
Gábor Endre Tóth,Anna Nagy,Jaime A Costales et al.
Gábor Endre Tóth et al.
Genomic surveillance of Usutu virus (USUV) in blood donors is hampered by extremely low viral loads, which usually prevent reliable genome sequencing. We developed and validated a tiled amplicon-based sequencing protocol optimized for low-t...
Etiological surveillance of viral gastroenteritis in children aged less than 5 years in Tehran Province, Iran, 2023-2024 [0.03%]
伊朗德黑兰省2023-2024年5岁以下儿童病毒性胃肠炎病因监测
Somayeh Sadat Hosseini Fakhr,Hassan Karami,Motahareh Shafiei et al.
Somayeh Sadat Hosseini Fakhr et al.
Background: Acute gastroenteritis (AGE) is a primary cause of death in children less than five years old in low- and middle-income countries (LMIC), mostly caused by viral intestinal infections. While the disease poses a ...
Identification of key genes associated with T cell exhaustion in HIV infection based on transcriptomic data [0.03%]
基于转录组数据识别与HIV感染相关的T细胞耗竭的关键基因
Yan Zhang,Yutao Yong,Wenqing Liu et al.
Yan Zhang et al.
Background: Human immunodeficiency virus (HIV) is a lentivirus belonging to the retrovirus subclass. HIV specifically targets and infects human CD4 + T lymphocytes, and T cell exhaustion (TEX) plays an important role in d...