Prevalence and genotype distribution of human papillomavirus infections in Beijing, China between 2016 and 2020 [0.03%]
2016至2020年中国北京人乳头瘤病毒感染率及基因型分布研究
Wei Zhang,Nan Guo,Baoping Li et al.
Wei Zhang et al.
Background: Certain types of human papillomavirus (HPV) induce long-lasting infections that cause cervical cancer. This study evaluated the prevalence of HPV infections and the distribution of their genotypes among clinic...
Development and validation of a duplex real-time PCR for the rapid detection and quantitation of HTLV-1 [0.03%]
HTLV-1的快速检测和定量双重实时PCR的发展与验证
Huimin Ji,Le Chang,Ying Yan et al.
Huimin Ji et al.
Background: The HTLV-1 prevalence in China varies geographically, while HTLV-2 infection has rarely been found so far. Proviral load is one of the determining factors of pathogenesis and progression of HTLV-1 related dise...
Development of an assay system for the analysis of host RISC activity in the presence of a potyvirus RNA silencing suppressor, HC-Pro [0.03%]
在存在一种杆状病毒感染RNA沉默抑制剂HC-Pro的情况下，建立分析宿主RISC活性的检测系统的发展
Syuan-Fei Hong,Ru-Ying Fang,Wei-Lun Wei et al.
Syuan-Fei Hong et al.
Background: To investigate the mechanism of RNA silencing suppression, the genetic transformation of viral suppressors of RNA silencing (VSRs) in Arabidopsis integrates ectopic VSR expression at steady state, which overco...
Ethanol extract from Artemisia argyi leaves inhibits HSV-1 infection by destroying the viral envelope [0.03%]
艾叶乙醇提取物通过破坏病毒包膜抑制HSV-1感染
Ping Liu,Lishan Zhong,Ji Xiao et al.
Ping Liu et al.
Herpes simplex virus type 1 (HSV-1) is a widely disseminated virus that establishes latency in the brain and causes occasional but fatal herpes simplex encephalitis. Currently, acyclovir (ACV) is the main clinical drug used in the treatment...
A noninvasive model discriminating significant histological changes in treatment-naive chronic hepatitis B patients with normal ALT [0.03%]
非侵入性模型区分ALT正常的初治慢性乙型肝炎患者中的重要组织学改变
Jiaming Teng,Yanan Du,Phimphone Visalath et al.
Jiaming Teng et al.
Background: Traditionally part of chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) are recommended to antiviral therapy referring to liver biopsy. However, liver biopsy is an invasive method w...
The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and diagnostics [0.03%]
SARS-CoV-2核衣壳蛋白：其在病毒生命周期、结构和功能中的作用，以及作为疫苗和诊断开发中潜在靶点的应用
Wenbing Wu,Ying Cheng,Hong Zhou et al.
Wenbing Wu et al.
Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal health, healthcare systems, and economies around the globe. Scientists are expending tremendous effort to develop diagnostic technologies for detecting positive ...
Xiaohan Yang,Lei Duan,Wenli Zhan et al.
Xiaohan Yang et al.
Background: Enterovirus (EV) infections are being increasingly seen in younger infants, often being more severe than in older children. The risk factors of EV infection in infants have been inadequately investigated till ...
The changed endemic pattern of human adenovirus from species B to C among pediatric patients under the pressure of non-pharmaceutical interventions against COVID-19 in Beijing, China [0.03%]
非药物干预下中国北京儿科患者人腺病毒种属由B向C的转变
Fangming Wang,Runan Zhu,Yuan Qian et al.
Fangming Wang et al.
Background: Under the pressure of non-pharmaceutical interventions (NPIs) targeting severe acute respiratory syndrome coronavirus 2, the prevalence of human adenovirus (HAdV) was monitored before and after NPIs launched o...
Trajectory of confirmed cases and deaths: fourth wave of COVID-19 epidemic in Myanmar [0.03%]
确诊病例和死亡人数的变化轨迹：缅甸第四波新冠疫情
Ye Minn Htun,Thinzar Aung,Myo Su Kyi et al.
Ye Minn Htun et al.
The current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 has affected day-to-day life worldwide and presents an unprecedented challenge to public health. Many countries performed mit...
Reactive oxygen species enhance rAAV transduction by promoting its escape from late endosomes [0.03%]
活性氧通过促进其从晚期内体逃逸来增强rAAV转导能力
Xiaoping Huang,Xiao Wang,Yanxuan Ren et al.
Xiaoping Huang et al.
Background: Recent seminal studies have revealed that endosomal reactive oxygen species (ROS) promote rather than inhibit viral infection. Some ROS generators, including shikonin and H2O2, have the potential to enhance re...