Targeting SARS-CoV-2 main protease: a comprehensive approach using advanced virtual screening, molecular dynamics, and in vitro validation [0.03%]
针对SARS-CoV-2主要蛋白酶的药物设计：采用先进的虚拟筛选、分子动力学及体外验证的综合策略
Smbat Gevorgyan,Hamlet Khachatryan,Anastasiya Shavina et al.
Smbat Gevorgyan et al.
The COVID-19 pandemic, driven by the SARS-CoV-2 virus, necessitates the development of effective therapeutics. The main protease of the virus, Mpro, is a key target due to its crucial role in viral replication. Our study presents a novel ap...
Bryce M Warner,David Safronetz,Derek R Stein
Bryce M Warner
Lassa virus, the cause of deadly Lassa fever, is endemic in West Africa, where thousands of cases occur on an annual basis. Nigeria continues to report increasingly severe outbreaks of Lassa Fever each year and there are currently no approv...
Herpes simplex virus-induced upregulation of inflammatory cytokines in human gingival fibroblasts [0.03%]
单纯疱疹病毒诱导的人牙龈纤维细胞炎性细胞因子的上调
Yu Zhang,Kalam Lo,Chunmei Wang et al.
Yu Zhang et al.
Herpes simplex virus type 1 (HSV-1) is the leading pathogen in the maxillo-facial region, affecting millions of individuals worldwide. Its periodic reactivation aligns with the most common course pattern of periodontal disease. The present ...
Investigating the effect of echinacea extraction syrup on the outcomes of lower respiratory infections in patients with COVID-19: a randomized clinical trial study [0.03%]
探究艾草提取糖浆对COVID-19患者下呼吸道感染结局的影响：一项随机临床试验研究
Elham Kheirandish,Mehrsadat Mahdizadeh,Mousa Mahdizadeh et al.
Elham Kheirandish et al.
Introduction: Many COVID-19 patients experience mild to severe symptoms, including respiratory system involvement. Different treatment instructions have been suggested for patients with COVID-19. Echinacea has known antiv...
Randomized Controlled Trial
Virology journal. 2024 Dec 19;21(1):319. DOI:10.1186/s12985-024-02586-6 2024
CRISPR/Cas12a and recombinase polymerase amplification-based rapid on-site nucleic acid detection of duck circovirus [0.03%]
基于CRISPR/Cas12a和重组聚合酶扩增的快速现场检测鸭圆环病毒核酸检测方法
Qi-Zhang Liang,Wei Chen,Rong-Chang Liu et al.
Qi-Zhang Liang et al.
Background: Duck circovirus (DuCV) infections commonly induce immunosuppression and secondary infections in ducks, resulting in significant economic losses in the duck breeding industry. Currently, effective vaccines and ...
Siti Saleha Binte Mohamed Yakob Adil,Joseph Tucci,Helen Irving et al.
Siti Saleha Binte Mohamed Yakob Adil et al.
The use of bacteriophages for therapy has increased over the last decade. While there is need for clear regulatory pathways for bacteriophage approval for mainstream use in clinical practice, practitioners and patients have been able to acc...
The importance of paying attention to the role of lipid-lowering drugs in controlling dengue virus infection [0.03%]
注意降脂药在登革病毒防治中可能的作用
Omer Qutaiba B Allela,Mohamad Ghazanfari Hashemi,Seyede Mozhgan Heidari et al.
Omer Qutaiba B Allela et al.
The Flaviviridae family includes the dengue virus (DENV). About half of the world's population is in danger because of the estimated 390 million infections and 96 million symptomatic cases that occur each year. An effective treatment for de...
Development and validation of a predictive model for metabolic syndrome in a large cohort of people living with HIV [0.03%]
在一大群艾滋病病毒感染者中代谢综合征预测模型的开发和验证
Suling Chen,Yuyuan Xu,Yuanhui Jiang et al.
Suling Chen et al.
Background: The global prevalence of metabolic syndrome (MetS) in people living with HIV (PLWH) is on the rise in the post era of antiretroviral therapy (ART). Nevertheless, there are no validated predictive models availa...
Correction: Peripheral immune signatures associated with the risk of hepatocarcinogenesis in cirrhotic Egyptian HCV patients before and after treatment with direct-acting antivirals [0.03%]
校正：直接抗病毒治疗前後埃及HCV肝硬化患者与肝细胞癌发生风险相关的外周免疫特征分析
Reem El-Shenawy,Rehab I Moustafa,Naiera M Helmy et al.
Reem El-Shenawy et al.
Published Erratum
Virology journal. 2024 Dec 12;21(1):317. DOI:10.1186/s12985-024-02598-2 2024
Risk factors for SARS-CoV-2 pneumonia among renal transplant recipients in Omicron pandemic-a prospective cohort study [0.03%]
奥密克戎疫情期间肾移植受者SARS-CoV-2肺炎的危险因素-前瞻性队列研究
Sai Zhang,Xiang Ding,Chunmi Geng et al.
Sai Zhang et al.
Background: The coronavirus disease (COVID-19) pandemic is a global health emergency, and SARS-CoV-2 pneumonia poses significant challenges to health systems worldwide. Renal transplant recipients (RTRs) are a special gro...