Development of a luminex-based assay for the detection of anti-capripoxvirus and rift valley fever virus antibodies in domestic ruminants [0.03%]
一种用于检测家养反刍动物中山羊皮炎和黏膜综合症病毒及裂谷热病毒抗体的液相芯片技术试验方法的研究开发
Francisco J Berguido,Tirumala Bharani Kumar Settypalli,Curé Georges Tshilenge Mbuyi et al.
Francisco J Berguido et al.
The three members of the genus capripoxvirus (CaPV), lumpy skin disease virus (LSDV), sheeppox virus (SPPV), and goatpox virus (GTPV) have common hosts and areas of overlapping geographical distribution with Rift Valley fever virus (RVFV). ...
Evolutionary variation of the monkeypox virus detected for the first time in Nantong, Jiangsu [0.03%]
我国江苏南通报告首例猴痘病毒进化分支变异病例
Xingpei Ji,Ruyue Liang,Chao Bao et al.
Xingpei Ji et al.
Monkeypox (MPOX) is a zoonotic disease caused by Orthopoxvirus monkeypox (MPXV), belonging to the Orthopoxvirus genus, and exhibits symptoms similar to smallpox. In 2024, the monkeypox outbreak in the Democratic Republic of the Congo contin...
A predictive model for functional cure in chronic HBV patients treated with pegylated interferon alpha: a comparative study of multiple algorithms based on clinical data [0.03%]
基于临床数据的多种算法比较研究构建慢性乙肝患者接受长效干扰素治疗的功能性治愈预测模型
Ya-Mei Ye,Yong Lin,Fang Sun et al.
Ya-Mei Ye et al.
Background: A multivariate predictive model was constructed using baseline and 12-week clinical data to evaluate the rate of clearance of hepatitis B surface antigen (HBsAg) at the 48-week mark in patients diagnosed with ...
Comparative Study
Virology journal. 2024 Dec 23;21(1):333. DOI:10.1186/s12985-024-02599-1 2024
The value of promoter methylation of fibroblast factor 21 (FGF21) in predicting the course of chronic hepatitis B and the occurrence of oxidative stress [0.03%]
成纤维细胞生长因子21(FGF21)启动子甲基化在预测慢性乙型肝炎转归及氧化应激发生中的价值
Xue Li,Pei Liu,Zhaohui Wang et al.
Xue Li et al.
Background: Oxidative stress plays a crucial role in the pathogenesis of HBV. This study aimed to investigate the value of fibroblast growth factor 21 (FGF21) promoter methylation in the occurrence and development of chro...
Tracking cryptic SARS-CoV-2 hospital outbreak through quasispecies analysis [0.03%]
通过拟种分析追踪隐秘的医院SARS-CoV-2群集感染事件
Serena Messali,Marta Giovanetti,Alessandro Rondina et al.
Serena Messali et al.
Background: Since the beginning of the pandemic, contact tracing has been one of the most relevant issues to understand SARS-CoV-2 transmission dynamics and, in this context, the analysis of quasispecies may turn out to b...
Safety, pharmacokinetics, and antiviral efficacy of the novel capsid assembly modulator GST-HG141 in patients with chronic hepatitis B: a phase 1 trial with a randomized, placebo-controlled design [0.03%]
新型衣壳装配调节剂GST-HG141治疗慢性乙型肝炎患者的安全性、药动学和抗病毒疗效：一项一期随机双盲安慰剂对照试验
Min Wu,Jiajia Mai,Hong Zhang et al.
Min Wu et al.
In preclinical studies, GST-HG141, a novel hepatitis B virus (HBV) capsid assembly modulator displayed potent anti-HBV activity in vitro and strong efficacy in HBV animal models. A randomized, double-blind, ascending phase 1b trial assessed...
Clinical Trial
Virology journal. 2024 Dec 20;21(1):328. DOI:10.1186/s12985-024-02584-8 2024
Identification and phylogenetic analysis of Jingmen tick virus in ticks and sheep from Henan Province, China [0.03%]
中国河南蜱虫和羊中荆门蜱病毒的鉴定及进化分析
Baicheng Xia,Zhenhua Li,Wenbing Zhu et al.
Baicheng Xia et al.
Jingmen tick virus (JMTV) is a novel segmented Flavivirus that was first identified from Rhipicephalus microplus in the Jingmen region of Hubei Province, China, in 2010. Subsequently, it was detected in a variety of countries and regions ar...
Calceolarioside B inhibits SARS-CoV-2 Omicron BA.2 variant cell entry and modulates immune response [0.03%]
石斛内酯B能够抑制新冠病毒奥密克戎变异株细胞侵入并调节免疫反应
Xiao-Bin Lin,Yu-Zhi Yao,Qi-Rong Wen et al.
Xiao-Bin Lin et al.
This study evaluated the inhibitory effects of calceolarioside B, extracted from the traditional Chinese herb Mutong (Akebia quinata Thumb), on the SARS-CoV-2 Omicron BA.2 variant. Molecular docking and molecular dynamics simulations predic...
The role of inflammatory gene polymorphisms in severe COVID-19: a review [0.03%]
炎症基因多态性在重症COVID-19中的作用：综述
Jia Qi Yip,Adrian Oo,Yan Ling Ng et al.
Jia Qi Yip et al.
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global healthcare systems and spurred extensive research efforts over the past three years. One critical aspect of the disease is the intricate inter...
Evolutionary dynamics of PRRS virus in Italian Pig farms: a retrospective study [0.03%]
意大利猪场PRRSV的进化动态：一项回顾性研究
Giovanni Parisio,Giovanni Franzo,Ilaria Barbieri et al.
Giovanni Parisio et al.
Porcine Reproductive and Respiratory Syndrome (PRRS) causes huge economic losses to pig farms worldwide. Currently available vaccines do not always offer complete protection, due to the extreme variability of the virus. Therefore, good farm...