Efficacy and safety of SHEN26, a novel oral small molecular RdRp inhibitor for COVID-19 treatment: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial [0.03%]
SHEN26治疗新冠感染有效性和安全性：一种新型口服RdRp抑制剂II期临床试验
Jiangtao Bai,Tetsuya Asakawa,Wenfang Yuan et al.
Jiangtao Bai et al.
Background: SHEN26 (ATV014) is an oral RNA-dependent RNA polymerase (RdRp) inhibitor with potential anti-SARS-CoV-2 activity. Safety, tolerability, and pharmacokinetic characteristics were verified in a Phase I study. Thi...
Clinical Trial
Virology journal. 2025 Jan 25;22(1):16. DOI:10.1186/s12985-025-02631-y 2025
Evaluation of host immune responses to Mycobacteriophage Fionnbharth by route of delivery [0.03%]
给药途径对宿主免疫系统中Mycobacteriophage Fionnbharth应答的影响评估研究
Thomas Smytheman,Tiffany Pecor,Dana E Miller et al.
Thomas Smytheman et al.
For much of the last decade, tuberculosis (TB) was the leading cause of mortality due to an infectious pathogen (Mycobacterium tuberculosis, M.tb). Approximately 1.3 million deaths in 2023 worldwide were attributed to TB disease. Focused in...
Incidence and estimated risk of residual transmission of hepatitis a virus and parvovirus B19 by blood transfusion in the state of Rio De Janeiro - Brazil: a retrospective study [0.03%]
巴西里约热内卢州献血后经血传播肝炎病毒和B19(parvovirus B19)的风险：一项回顾性研究
Arthur Daniel Rocha Alves,Mariana Magaldi,Ana Carolina Sathler de Menezes et al.
Arthur Daniel Rocha Alves et al.
Background: Nonenveloped viruses, such as hepatitis A virus (HAV) and parvovirus B19 (B19V), are not inactivated by detergents and solvents commonly used to manufacture plasma derivatives. Cases of transfusion-transmitted...
The role of human leukocyte antigen in HTLV-1 infection and progression to ATLL and HAM/TSP: a systematic review and meta-analysis [0.03%]
人类白细胞抗原在HTLV-1感染及向ATLL和HAM/TSP进展中的作用：系统性回顾和meta分析
Shayan Mardi,Maryam Rashidian,Fatemeh Bastan et al.
Shayan Mardi et al.
Background: Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that leads to lifelong infection and multiple diseases, including HAM/TSP and ATLL. Despite extensive research, the exact pathophysiology of HTLV...
Construction of a Vero cell line expression human KREMEN1 for the development of CVA6 vaccines [0.03%]
建立表达人KREMEN1的 vero细胞系用于CVA6疫苗研发
Dongqing Zhang,Yuxiang Zou,Jiaying Wu et al.
Dongqing Zhang et al.
Coxsackievirus A6 (CVA6) has emerged as a major pathogen causing hand, foot and mouth disease (HFMD) outbreaks worldwide. The CVA6 epidemic poses a new challenge in HFMD control since there is currently no vaccine available against CVA6 inf...
Impact of antiviral prophylaxis on EBV viremia and posttransplant lymphoproliferative disorders in solid organ transplant recipients: a systematic review and meta-analysis [0.03%]
抗病毒预防对实体器官移植受者的EBV病毒血症和移植后淋巴增殖性疾病的影响：系统评价和Meta分析
Marjan Moghadamnia,Khadijeh Delroba,Shima Heidari et al.
Marjan Moghadamnia et al.
Introduction: Organ transplant recipients face a substantial risk of developing posttransplant lymphoproliferative disorders (PTLD). In over 90% of cases with B-cell PTLD following solid organ transplantation, the Epstein...
The virome composition of respiratory tract changes in school-aged children with Mycoplasma pneumoniae infection [0.03%]
支原体肺炎感染学龄儿童呼吸道病毒组结构的变化
Dianqi Zhang,Yang Cao,Biao Dai et al.
Dianqi Zhang et al.
Background: Mycoplasma pneumoniae (MP) is a common pathogen for respiratory infections in children. Previous studies have reported respiratory tract microbial disturbances associated with MP infection (MPI); however, sinc...
SARS-CoV-2 excretion and genetic evolution in nasopharyngeal and stool samples from primary immunodeficiency and immunocompetent pediatric patients [0.03%]
原发性免疫缺陷和免疫功能正常的儿童患者鼻咽部及粪便样本中SARS-CoV-2的排出及其基因组进化规律研究
Haifa Khemiri,Ilhem Ben Fraj,Alessio Lorusso et al.
Haifa Khemiri et al.
Background: Primary Immunodeficiency disorders (PID) can increase the risk of severe COVID-19 and prolonged infection. This study investigates the duration of SARS-CoV-2 excretion and the genetic evolution of the virus in...
A new approach for detecting HPV DNA in cervical swabs: comparison of nucleic acid extraction with direct PCR [0.03%]
一种新的检测宫颈拭子样本中HPV DNA的方法：核酸提取与直接PCR的比较
Fatih Çubuk,Muhammet Çağrı Yıldız,Fikrican Balcı et al.
Fatih Çubuk et al.
Background: Almost all cases of cervical cancer are associated with persistent high-risk HPV infection. WHO prioritizes primary HPV testing for cervical cancer screening. Cervical cancer screening programs require the abi...
Comparative Study
Virology journal. 2025 Jan 11;22(1):8. DOI:10.1186/s12985-024-02601-w 2025
Evaluation of the role of unconventional prefoldin RPB5 interactor (URI1) in hepatitis B virus infection [0.03%]
评估非常规RPB5互作因子URI1在乙型肝炎病毒感染中的作用
Karolína Štaflová,Aleš Zábranský,Iva Pichová
Karolína Štaflová
Hepatitis B virus (HBV) infection can cause liver disease and lead to hepatocellular carcinoma (HCC). To better understand the factors involved in viral infection and pathogenesis and to develop novel therapies, it is crucial to investigate...