Long-term culture of chicken tracheal organoids for the purpose of avian influenza virus research [0.03%]
鸡支气管类器官的长期培养在禽流感研究中的应用
Anja C M de Bruin,Mart M Lamers,Bart L Haagmans et al.
Anja C M de Bruin et al.
There is an increasing need for reproducible long-term in vitro primary cell culture systems that are representative of the avian respiratory tract to study pathogens like highly pathogenic avian influenza viruses (HPAIVs), which threaten p...
A novel approach utilizing spirocyclic thiopyrimidinone compounds against herpes simplex virus with underlying antiviral mechanisms of action [0.03%]
一类新型螺环噻嘧啶酮化合物抗单纯疱疹病毒活性及作用机制的研究
Esraa A Manie,Emad M Elzayat,Sherif S Ragab et al.
Esraa A Manie et al.
In recent decades, viral outbreaks have significantly threatened global health, with herpes simplex virus type 2 (HSV-2) being one of the most prevalent infections. This study evaluated novel spiropyrimidine derivatives as potential antivir...
Immunogenicity of a foot-and-mouth disease (FMD) vaccine against serotypes O, A, SAT-2, and Asia-1 in the Middle East and many parts of Africa, Southeast Asia and Europe [0.03%]
一种针对O、A、SAT-2和Asia-1型口蹄疫（FMD）血清型疫苗在中东及非洲大部地区、东南亚以及欧洲的免疫原性研究
Momtaz Wasfy,Abdel Hamid Bazid,Mohamed Nayel et al.
Momtaz Wasfy et al.
Control of foot-and-mouth disease (FMD) is hampered by inadequate biosecurity measures, border transcending serotype strains and unavailability of broad coverage vaccines. In this investigation, six FMD antibody-free calves, aged 1.5-2 year...
Evaluation of the duration of new nasal drug interferon α-2b activity in an experimental model system [0.03%]
新鼻用药物干扰素α-2b活性持续时间的评价动物实验模型研究
N Bezdieniezhnykh,O Lykhova,G Borshchevskiy et al.
N Bezdieniezhnykh et al.
This study aimed: To develop an adequate system for assessing the duration of IFN antiviral activity in the nasal cavity of animals and to study the antiviral activity of a new IFN drug in the form of a gel in comparison ...
Development of an RT-RPA assay for La Crosse virus detection provides insights into age-dependent neuroinvasion in mice [0.03%]
一种用于拉沙烈病毒检测的RT-RPA检测试剂盒的开发为小鼠年龄依赖性神经侵袭提供了研究见解
Lily Lumkong,Reem Alatrash,Sainetra Sridhar et al.
Lily Lumkong et al.
Background: La Crosse virus (LACV) is a mosquito-borne arbovirus responsible for pediatric encephalitis in North America, predominantly affecting children under 16 years. Early and accurate diagnosis is critical to reduci...
Genetic determinants of HIV-1 subtype C Nef-mediated SERINC3 down-regulation [0.03%]
HIV-1型C亚型Nef调控SERINC3的遗传决定因子
Nikeisha Samlall,Tarylee Reddy,Nasreen Ismail et al.
Nikeisha Samlall et al.
Background: Nef-mediated down-regulation of the host restriction factors SERINC3 and SERINC5 significantly enhances HIV-1 infectivity. Natural Nef polymorphisms that affect SERINC3 down-regulation are not as well-characte...
Identification of Co-29, a 5-cyano-2-thiacetyl aromatic pyrimidinone, as a potential inhibitor targeting the RdRp of norovirus [0.03%]
鉴定Co-29（5-氰基-2-硫乙酰芳基吡啶酮）为针对诺如病毒RdRp的潜在抑制剂
Xianglan Liu,Jiaming Hu,Jiarui Wu et al.
Xianglan Liu et al.
Background: Human norovirus (HNV) is the predominant pathogen causing outbreaks of acute gastroenteritis globally. Despite significant efforts to combat norovirus infections, there is currently no FDA approved vaccine or ...
Isolation, molecular identification, and phylogenetic analysis of infectious bronchitis virus from commercial chicken farms in Mekele and Bishoftu, Ethiopia, 2023-2024 [0.03%]
2023-2024年埃塞俄比亚mekelle和bishoftu商业鸡场传染性支气管炎病毒的分离、分子鉴定及系统发育分析
Nigusu Berhanu,Eyob Hirpa,Hawa Mohammed et al.
Nigusu Berhanu et al.
Background: Avian infectious bronchitis (IB) is a highly contagious respiratory disease that affects the poultry industry globally. The disease is caused by avian infectious bronchitis virus (IBV), member of the genus Gam...
Characterization of the epidemiology, susceptibility genes and clinical features of viral infections among children with inborn immune errors: a retrospective study [0.03%]
儿童先天性免疫缺陷病毒性感染的流行病学、易感基因和临床特征研究：回顾性研究
Haiqiao Zhang,Wenjie Wang,Qinhua Zhou et al.
Haiqiao Zhang et al.
Background: Although viral infections are one of the common clinical manifestations in patients with inborn errors of immunity (IEIs), little is known about the epidemiology, susceptibility genes, and clinical status of v...
Identification and characterization of a novel reovirus strain isolated fromgrass carp (Ctenopharyngodon idella) [0.03%]
草鱼分离的新轮状病毒的鉴定与表征
Weiguang Kong,Guangyi Ding,Qiushi Zhang et al.
Weiguang Kong et al.
Background: Grass carp (Ctenopharyngodon idella) hemorrhagic disease (GCHD) is a devastating disease that leads to substantial economic losses in the freshwater aquaculture industry. ...