Lipid droplets as redox-active organelles after spinal cord injury: lipid peroxidation, mitochondrial dysfunction, and neuroinflammation [0.03%]
脊髓损伤后作为活性红氧器官的脂滴：脂质过氧化、线粒体功能障碍和神经炎症
Yichen Zhang,Jie Li,Yinan Liu et al.
Yichen Zhang et al.
Objectives: Spinal cord injury (SCI) causes myelin breakdown and membrane disruption, leading to the release and redistribution of cholesterol, fatty acids, and other lipids within the lesion. The resulting disruption of ...
DMAMCL induces ferroptosis in neuroblastoma by targeting HMOX1 in MYCN-amplified subtypes whereas targeting STEAP3 in MYCN-nonamplified subtypes [0.03%]
DMAMCL通过靶向HMOX1在MYCN扩增亚型中诱导神经母细胞瘤铁死亡，而靶向STEAP3则用于非扩增亚型
Yifan Ma,Simeng Zhang,Dongyang Zhang et al.
Yifan Ma et al.
Objectives: Neuroblastoma (NB) is a common pediatric extracranial solid tumor. Dimethylaminomicheliolide (DMAMCL), a prodrug of Micheliolide (MCL), shows antitumor activity against NB, but its mechanisms remain unclear. T...
Repurposing nitazoxanide as a novel ferroptosis inducer for triple-negative breast cancer via dual disruption of iron homeostasis and the β-catenin/GPX4 axis [0.03%]
尼扎替丁作为新型铁死亡诱导剂治疗三阴性乳腺癌：通过双重干扰铁稳态和β-连环素/GPX4轴
Chenshan Zhang,Ting Yang,Yuxuan Meng et al.
Chenshan Zhang et al.
Background: Ferroptosis induction is a promising triple-negative breast cancer (TNBC) therapy, but current inducers are suboptimal. Nitazoxanide (NTZ), an FDA-approved antiparasitic with anticancer and redox activity, may...
HIV-1 gp120-induced lysosomal stress responses are controlled by TRPML1 redox sensors [0.03%]
TRPML1氧化还原感受器控制HIV-1 gp120诱导的自噬溶酶体应激反应
Nirmal Kumar,Braelyn Liang,Jonathan D Geiger
Nirmal Kumar
Background: Increased lysosomal stress responses (LSR) are commonly implicated in the pathogenesis of neurodegenerative disorders including HIV-1-associated neurocognitive disorders (HAND). The HIV-1 envelope glycoprotein...
Nuria Goya-Iglesias,Bess Yi Kun Yu,Ivan Gout et al.
Nuria Goya-Iglesias et al.
Objectives: Type III intermediate filaments, such as vimentin, GFAP, and desmin, are involved in cell mechanics, signaling, and stress responses, and are tightly regulated by posttranslational modifications (PTMs). The mo...
Ovalbumin oxidative modification fingerprints depend on gas plasma-driven reactive species profiles [0.03%]
卵白蛋白氧化修饰标记依赖等离子体驱动反应物种类型
Paul Schulan,Kristian Wende,Ramona Clemen et al.
Paul Schulan et al.
Objective: Oxidative protein modifications have been linked to several diseases, but the variety and diversity of modifications are less studied. Methods:...
Significance of GSH and H2S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health [0.03%]
谷胱甘肽和氢硫酸调节在癌症中的意义：饮食、微生物群、代谢重编程与免疫健康的复杂相互作用
Avisek Majumder,Suravi Majumder,Shabana Bano et al.
Avisek Majumder et al.
Due to the proliferative nature of cancer cells, they utilize more dietary extracellular nutrients via one-carbon metabolism for the various metabolic processes, including the synthesis of antioxidants such as glutathione (GSH) and hydrogen...
Felipe Caliani Mathias-Netto,Nathalia Margarida Cantuária,Renato Simões Gaspar
Felipe Caliani Mathias-Netto
Objectives: Collagen is a long-lived protein present in the extracellular matrix of force-bearing tissues. It has a unique amino acid composition of predominantly glycine, proline and hydroxyproline that repeats throughou...
Rhaponticin alleviates pancreatic acinar cell necrosis by attenuating oxidative stress via modulation of the HIF-1α signaling pathway [0.03%]
雷公藤春碱通过调节缺氧诱导因子-1α信号途径降低氧化应激缓解胰腺腺泡细胞坏死
Xinyue Xie,Pei Yang,Shuai Wang et al.
Xinyue Xie et al.
Objectives: This study investigated the protective effects and mechanisms of rhaponticin (Rha) against acinar cell injury in acute pancreatitis (AP). Meth...
The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart [0.03%]
胱硫醚-β-合成酶介导的半胱氨酸代谢调节在铁诱导的心脏氧化损伤中起重要作用
Yong Zhang,Yijun Xin,Jie Zhou et al.
Yong Zhang et al.
Objectives: Iron overload (IO) cardiomyopathy is a major cause of mortality in patients with iron overload disorders. This study investigates the role of cystathionine γ-lyase (CSE), a key enzyme in the transsulfuration ...