Macrophage metabolic reprogramming via HIF-1α-glycolysis drives osteoblast ferroptosis and bone loss through an IL-6-STAT3-dependent redox axis [0.03%]
巨噬细胞通过HIF-1α-糖酵解代谢重编程驱动成骨细胞铁死亡和骨丢失的IL-6-STAT3依赖性红氧平衡轴机制
Yifan Gu,Kun Wang,Yicong Wang et al.
Yifan Gu et al.
Background: Postmenopausal osteoporosis (PMOP) is characterized by exacerbated bone resorption and inadequate bone formation, with macrophage-driven inflammation playing a key role. However, how immunometabolic reprogramm...
EGCG-loaded nanoparticles attenuate post-SAH white matter injury by targeting HO-1/S100A10 to suppress oxidative stress-induced reactive astrocytes [0.03%]
表没食子儿茶素没食子酸酯载药纳米粒通过靶向HO-1/S100A10通路抑制氧化应激诱导的反应性星形胶质细胞减轻蛛网膜下腔出血后白质损伤
Dongcen Lang,Yanning Zheng,Jing Zhang et al.
Dongcen Lang et al.
Objective: Subarachnoid hemorrhage (SAH) is associated with high mortality and poor outcomes, which are closely related to white matter injury (WMI). (-)-Epigallocatechin-3-gallate (EGCG) exerts neuroprotective effects by...
Bilirubin reduces mortality in sepsis models by inhibiting NOX2-mediated formation of neutrophil extracellular traps [0.03%]
胆红素通过抑制NOX2介导的中性粒细胞胞外陷阱形成减少脓毒症模型中的死亡率
Sang-Jin Kim,Chang Woo Ko,Wan-Seo Kim et al.
Sang-Jin Kim et al.
Objectives: Sepsis is a life-threatening condition driven by a dysregulated immune response to infection, yet therapeutic options beyond antibiotics and vasopressors remain limited. Neutrophil extracellular traps (NETs) c...
Elucidating the protective role of quercetin against lipopolysaccharide-induced necroptosis in broiler thymus: insights from Nrf2/PERK signaling based on network pharmacology and experimental validation [0.03%]
基于网络药理学和实验验证的山柰酚对脂多糖诱导的肉鸡胸腺坏死性凋亡保护作用及Nrf2/PERK信号通路研究
Yu Xia,Ruirui Xie,Xinyu Huo et al.
Yu Xia et al.
Objectives: Quercetin (QUE) possesses antioxidant, anti-inflammatory, and immunomodulatory functions. Nuclear factor erythroid 2-related factor 2 (Nrf2) can initiate protein kinase RNA-like ER kinase (PERK), leading to im...
The oxidative stress paradigm in arbovirus infections: mechanisms and therapeutic insights [0.03%]
气候变化下的氧化应激与虫媒病毒入侵机制及应对措施
Chang Ke Yee,Rafidah Lani,Pouya Hassandarvish
Chang Ke Yee
Background: Arbovirus infections impose a substantial global health burden, further complicated by their ability to induce oxidative stress through excessive generation of reactive oxygen species (ROS). This oxidative str...
Oxidative stress in neurodegeneration: from a simple insult to a dynamic regulator [0.03%]
氧化应激与神经退行性疾病：从单纯的损伤到动态的调节者
Lan Zhang,Xinyue Zhai,Yalong Yan et al.
Lan Zhang et al.
Objectives: To evaluate the central role of oxidative stress in neurodegenerative diseases, and to explore its dynamic regulatory features, underlying signaling pathways, and molecular mechanisms, as well as advanced tech...
Sirtuin 5-mediated desuccinylation of PRDX6 inhibits ferroptosis and alleviates sepsis-associated acute kidney injury [0.03%]
乙酰化酶Sirtuin 5通过去琥珀酰化PRDX6抑制铁死亡以缓解脓毒症急性肾损伤
Wenlong Lin,Caitao Dong,Qinhong Jiang et al.
Wenlong Lin et al.
Objectives: To investigate the role of the SIRT5-PRDX6 axis during the pathogenesis of sepsis-associated acute kidney injury (SA-AKI). Methods: ...
Plasma proteomics implicates NOX-driven redox imbalance in degenerative cervical myelopathy: findings from the Australian MYelopathy Natural History Registry [AO Spine RECODE-DCM research priority number 5] [0.03%]
血浆蛋白质组学表明NOX介导的氧化还原失衡在脊髓型颈椎病中起作用：来自澳大利亚脊髓病自然史注册中心的结果[AO Spine RECODE-DCM研究优先项目编号5]
Nashwa Najib,Valerie C Wasinger,Ryan O&#x;Hare Doig et al.
Nashwa Najib et al.
Objectives: To identify disease-relevant pathways and biomarkers in degenerative cervical myelopathy (DCM) patients from the MYelopathy Natural History Registry. ...
Correction [0.03%]
改正与修正
Ferroptosis inhibition and mitochondrial rescue: a novel mechanism of emodin in rheumatoid arthritis [0.03%]
大黄素通过抑制铁死亡和线粒体保护治疗类风湿性关节炎的新机制研究
Linlan Zhou,Jun Liu,Jing Ren et al.
Linlan Zhou et al.
Objectives: Rheumatoid arthritis (RA) is characterized by chronic synovitis and progressive joint destruction. Ferroptosis has been implicated in RA pathogenesis through synovial iron accumulation and oxidative stress. Gl...