Neuroprotective effects of dexmedetomidine in spinal cord injury via modulating PERK/ATF4 pathway [0.03%]
右美托咪定通过调节PERK/ATF4通路发挥脊髓损伤神经保护作用
Lijun Yang,Bo Long,Huijun Yang
Lijun Yang
Objectives: This study explored whether dexmedetomidine (DEX) can promote functional restoration following spinal cord injury (SCI) through the PKR-like endoplasmic reticulum kinase (PERK)/activating transcription factor ...
Astragaloside IV alleviates neuroinflammation in cerebral ischemia-reperfusion injury by inhibiting HTR2B-mediated microglial M1 polarization [0.03%]
ASTRAGALOSIDE Ⅳ通过抑制HTR2B介导的小胶质细胞M1极化缓解脑缺血再灌注损伤神经炎症作用机制研究
Zhongfan Ruan,Yan Li,Yanfang Chen
Zhongfan Ruan
Objective: This study aims to elucidate the mechanism by which astragaloside IV (AS-IV) mitigates cerebral ischemia-reperfusion injury (CIRI), with a focus on serotonin receptor 2B (HTR2B)-mediated microglial polarization...
LncRNA MCM3AP-AS1 protects against cerebral ischemia-reperfusion injury via targeting miR-27b-3p [0.03%]
长链非编码RNA MCM3AP-AS1通过靶向miR-27b-3p防治脑缺血再灌注损伤
Rouli Dai,Wei Li,Bin Han
Rouli Dai
Objectives: Cerebral ischemia-reperfusion (CI/R) injury is a significant hurdle in ischemic stroke treatment. Substantial evidence indicates that long non-coding RNAs (lncRNAs) are implicated in CI/R injury. Here, we expl...
Sayantan Das
Sayantan Das
Background: Alzheimer's disease (AD) is the most common cause of dementia worldwide, affecting over 55 million individuals and projected to rise drastically in the coming decades. Characterized by progressive cognitive de...
The role of genetic factors in the occurrence of levodopa-induced motor complications in Parkinson's disease [0.03%]
遗传因素在帕金森病左旋多巴诱发的运动障碍发生中的作用
Branislava Radojević,Andona Milovanović,Igor Petrović et al.
Branislava Radojević et al.
Background: The genetic contribution to the development of levodopa-induced motor complications in Parkinson's disease (PD) remains poorly understood. Obj...
FGF21 restores metabolic function in Alzheimer's disease via activation of PI3K/Akt signaling [0.03%]
FGF21通过激活PI3K/Akt信号通路恢复阿尔茨海默病患者的代谢功能
Feng Zhao,Hui Yang,Huamei Liu et al.
Feng Zhao et al.
Background and objective: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, oxidative stress, and mitochondrial dysfunction. Fibroblast growth factor 21 (FGF21) has demonstrated ...
Nerve conduction study and nerve ultrasound as biomarkers for steroid dependence in chronic inflammatory demyelinating polyneuropathy [0.03%]
慢性炎症性脱髓鞘多发性神经病中作为糖皮质激素依赖生物标志物的神经传导研究和周围神经超声检查
Jingwen Niu,Nan Hu,Qingyun Ding et al.
Jingwen Niu et al.
Background: Biomarkers for disease activity are lacking in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We aimed to investigate whether motor nerve conduction studies (NCSs) and nerve ultrasound and t...
The impact of hemorrhage extension on external ventricular drain associated infections in patients with non-aneurysmal primary intracerebral and/or intraventricular hemorrhage [0.03%]
血肿扩大与自发性非动脉瘤性脑室内出血外引流相关感染的影响关系研究
Emilia Westarp,Florian Ebel,Simon Stohler et al.
Emilia Westarp et al.
Background: Ventriculostomy is a common intervention to treat acute hydrocephalus in patients with primary intracerebral (PICH) and primary intraventricular hemorrhage (PIVH). A variety of risk-factors for external ventri...
Aspirin versus recombinant tissue plasminogen activator for acute minor stroke: a systematic review and meta-analysis [0.03%]
阿司匹林与重组组织型纤溶酶原激活剂治疗急性轻微卒中的效果比较：系统评价和 meta 分析
João Vitor Andrade Fernandes,João Victor de Oliveira Ramos,Maurus Marques de Almeida Holanda
João Vitor Andrade Fernandes
Objectives: Minor ischemic stroke is common and may lead to significant disability, even when symptoms appear mild or are poorly tolerated. Treatment choice remains uncertain: Recombinant Tissue Plasminogen Activator (r-t...
Histone lactylation exacerbates cerebral ischemia-reperfusion injury via NSUN2-mediated epigenetic activation of astrocytic neuroinflammation [0.03%]
组蛋白乳酰化通过NSUN2介导的表观遗传激活星形胶质细胞神经炎症加剧脑缺血再灌注损伤
Jianmin Wang,Tong Zhang,Xiaoyu Zhang et al.
Jianmin Wang et al.
Objective: This study investigates how histone lactylation regulates NOP2/Sun RNA methyltransferase family member 2 (NSUN2)-mediated 5-methylcytosine (m5C) modification and promotes astrocyte-driven neuroinflammation in c...