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Histone lactylation exacerbates cerebral ischemia-reperfusion injury via NSUN2-mediated epigenetic activation of astrocytic neuroinflammation

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Objective: This study investigates how histone lactylation regulates NOP2/Sun RNA methyltransferase family member 2 (NSUN2)-mediated 5-methylcytosine (m5C) modification and promotes astrocyte-driven neuroinflammation in cerebral ... ...