Emerging Molecular Targets in Neurodegenerative Disorders: New Avenues for Therapeutic Intervention [0.03%]
神经退行性疾病中新兴的分子靶点：治疗干预的新途径
Ezgi Eroglu,Nusin Harmanci
Ezgi Eroglu
Neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and frontotemporal dementia represent a significant global health burden with limited therapeutic options. Cur...
Ocular Antibiotic Use in Young Danish Children From 2016 to 2024 [0.03%]
2016年至2024年丹麦年轻儿童的眼部抗生素使用情况
Heidi Sonne,Anton Pottegård,Katrine Sommerlund et al.
Heidi Sonne et al.
Kanika Rathi,Sakshi Sharma,Anil Barnwal
Kanika Rathi
Early detection of diseases is a critical pillar in advancing modern healthcare, offering timely interventions and better patient outcomes. This overview highlights a range of machine learning (ML) approaches that are transforming early dis...
Tools for Evaluating Potentially Inappropriate Medication Use in Older Adults: A Scoping Review Assessing Suitability for Register-Based Research [0.03%]
评估老年人潜在不适当用药的工具：适合基于登记册研究的适宜性系统综述
Katrine Mose,Carina Lundby,Lotte Rasmussen et al.
Katrine Mose et al.
This scoping review provides an overview of tools used to assess potentially inappropriate prescribing among older adults and discusses their suitability for register-based research. We performed a systematic search using PubMed (March 2024...
Barriers to and Enablers of Supporting Deprescribing Benzodiazepines in Older Adults: A Survey of European Nonphysician Healthcare Professionals [0.03%]
欧洲非医师医疗保健专业人员支持老年人停用苯二氮卓类药物的障碍与促进因素：一项调查研究
Vladyslav Shapoval,Perrine Evrard,François-Xavier Sibille et al.
Vladyslav Shapoval et al.
Although physicians are primarily responsible for Benzodiazepine Receptor Agonist (BZRA) deprescribing, nonphysician healthcare professionals (HCPs) can support deprescribing. This study explored barriers to and enablers of BZRA deprescribi...
Deprescribing Anticholinergic Medications in Hospitalised Older Adults: A Systematic Review [0.03%]
老年住院患者抗胆碱能药物的减药处方：系统评价研究
Rhianna Griffiths,Steve Lim,Julian Lin et al.
Rhianna Griffiths et al.
Background: Anticholinergic medication use is increasing, particularly among older adults due to polypharmacy and comorbidities. High anticholinergic burden is linked to adverse outcomes such as reduced mobility and incre...
Computer-Assisted Screening of Active Compounds in Traditional Chinese Medicine Targeting SNX10 as a Promising Treatment for Inflammatory Bowel Diseases [0.03%]
计算辅助筛选针对SNX10的中药活性成分用于治疗炎症性肠病
Yongpan An,Bowen Zhang,Yuwei Ye et al.
Yongpan An et al.
Inflammatory bowel diseases (IBD) are chronic and recurrent gastrointestinal disorders affecting millions worldwide, imposing significant social and economic burdens. Safe and effective medications for IBD prevention and treatment are urgen...
Comparative Safety Analysis of Avastin and Bevacizumab Biosimilars Based on Food and Drug Administration Adverse Event Reporting System [0.03%]
基于美国食品药品管理局不良事件报告系统评估阿瓦斯汀与贝伐单抗相似药的安全性分析研究
Xiaoyu Zhang,Yupeng Zhang,Xinghang Tang et al.
Xiaoyu Zhang et al.
Objective: This study aimed to compare adverse event (AE) profiles between Avastin and bevacizumab biosimilars to support clinical decision-making, given the limited availability of real-world data. ...
Comparative Study
Basic & clinical pharmacology & toxicology. 2025 Oct;137(4):e70099. DOI:10.1111/bcpt.70099 2025
Multi-Target Renal Protection of Wine-Processed Polygonatum sibiricum Against Cisplatin-Induced Nephrotoxicity: Integrated Phytochemistry, Network Pharmacology and Experimental Validation [0.03%]
采用综合植物化学、网络药理学及实验验证评价的少白党参酒剂多靶器官保护肾毒性的研究：以顺铂致急性肾损伤为例
Yu Jiang,Wei Qiao,Kaili Guo et al.
Yu Jiang et al.
Acute kidney injury (AKI) is a serious complication of cisplatin chemotherapy, with limited treatment options. In this study, we investigated the protective effects of wine-processed Polygonatum sibiricum (WP. P. sibiricum) against cisplati...
Assessing the Carcinogenic Potential of PFOA: A Molecular Network Approach to Liver Toxicity [0.03%]
以分子网络为基础评估PFOA的致癌潜能及其肝毒性作用机制
Libi Tan,Tianyu She,Siyan Huo et al.
Libi Tan et al.
Perfluorooctanoic acid (PFOA), a prototypical per- and polyfluoroalkyl substance (PFAS), is widely used in industrial and consumer products but is classified as a Group 1 carcinogen by the IARC due to its environmental persistence and bioac...