Nephroprotective Effects of Vanillic Acid on Bortezomib-Induced Renal Injury: Role of Oxidative Stress, Mitochondrial Dysfunction, Apoptosis and miR-204/Nephrin/Podocin/CD2AP Axis [0.03%]
Medine Akkan Öz,Hasan Şimşek,Selçuk Özdemir et al.
Medine Akkan Öz et al.
Bortezomib (BTZ) is clinically important in the nephrological field because of its increasing use in plasma cell disorders and antibody-mediated kidney diseases, where it can both exert therapeutic benefits and, paradoxically, cause signifi...
Community Pharmacists' Role in Antidepressant Discontinuation: A Survey of Barriers and Facilitators [0.03%]
Ketura Verheye,Ine Vangrieken,Kato De Pril et al.
Ketura Verheye et al.
Background: Long-term antidepressant use is widespread in high-income countries. While general practitioners (GPs) are central in reviewing and discontinuing antidepressants, community pharmacists (CP) may support this pr...
Pharmacology of Vitamin E [0.03%]
Maret G Traber
Maret G Traber
The mechanisms for the preferential α-tocopherol retention in the human body fall under the usual pharmacologic categories of absorption, disposition, metabolism and catabolism and excretion (ADME). Kinetic studies using α-tocopherol labe...
6-Nitrodopamine Potentiates Catecholamine-Induced Ca2+ i Release in Human Aortic Smooth Muscle and Modulates Vascular Smooth Muscle Contractility [0.03%]
José Britto-Júnior,Antonio Tiago Lima,Shuaihua Qiao et al.
José Britto-Júnior et al.
Background: In vascular smooth muscle, rises in intracellular calcium [Ca2+]i drive contraction downstream of α1-adrenoceptor activation via IP3. Endothelium-derived 6-nitrodopamine (6-ND) augments cardiac catecholamine ...
Amantadine Enhances IL-10 Expressions to Maintain the Renal Functions Against Inflammation and Oxidative Stress via Increasing PI3K/AKT/HIF-1α Pathway and Decreasing AQP2-4 Signallings [0.03%]
Alim Kosar,Pinar Aslan Kosar,Muhammet Yusuf Tepebasi et al.
Alim Kosar et al.
Background: This study aimed to show the beneficial effects of amantadine (AMA), used in antiviral medication and Parkinson's therapy, on the inflammatory response and apoptosis in a model of systemic inflammation induced...
Nintedanib Lacks Efficacy in a Spirometry-Confirmed and Bleomycin-Induced Mouse Model of Idiopathic Pulmonary Fibrosis [0.03%]
Nintedanib无法改善经肺功能检查确认的博来霉素诱导的特发性肺纤维化小鼠模型的症状
Jamal Bousamaki,Grzegorz Maciag,Asbjørn Graver Petersen et al.
Jamal Bousamaki et al.
Nintedanib, a multitargeted tyrosine kinase inhibitor, is approved for idiopathic pulmonary fibrosis (IPF) for its ability to slow lung function decline. This study systematically evaluated the effects of nintedanib across three independent...
A Retrospective Analysis of Human Angiotensin II Receptor Blockers (ARB) Pharmacokinetics, Dosages and Cmax Values for the Experimental Modelling of Pleiotropic and Supratherapeutic Activities [0.03%]
人用血管紧张素II受体阻滞剂（ARB）药代动力学、剂量和Cmax值的回顾性分析，以实验模型研究多效性和超治疗剂量活性
Alexandria Evans,Pascal Bernatchez
Alexandria Evans
Angiotensin II (AngII) receptor blockers (ARBs) are medications that lower systolic blood pressure (BP) by antagonizing the AngII type 1 receptor (AT1). However, ARBs have documented or suspected therapeutic properties in diseases not cause...
Neuroprotective Effects of Esketamine in Central Nervous System Disorders: Mechanisms and Cellular Targets [0.03%]
中枢神经系统疾病中的右酮色林神经保护作用：机制和细胞靶点
Chendi Zhao,Yan Wang,Jinglang Wu et al.
Chendi Zhao et al.
Esketamine (ESK), the dextrorotatory enantiomer of ketamine, is an antagonist of the N-methyl-D-aspartic acid (NMDA) receptor. ESK is considered an effective anesthetic because of its ability to mitigate postoperative pain and opioid use. R...
Pregnane X Receptor Regulates Human Endocrine System by Inducing Sex Hormone-Binding Globulin Expression [0.03%]
pregnane X受体通过诱导性激素结合球蛋白表达来调节人体内分泌系统
Maria H Ahonen,Anja Konzack,Tomas Smutny et al.
Maria H Ahonen et al.
Sex hormone-binding globulin (SHBG) is a sex hormone carrier. We aimed to characterize the role of pregnane X receptor (PXR), a major regulator of drug metabolism, in SHBG regulation. Serum SHBG was measured in four clinical trials (n = 61)...
Supporting General Practitioners to Deprescribe Benzodiazepines and Z-Drugs in Primary Care: Findings From a Modified Delphi Study [0.03%]
支持初级保健中的全科医生减少开具苯二氮卓类药物和Z类药物：一项改良德尔菲研究的发现
Erin Oldenhof,Megan Pisegna,Mark Horowitz et al.
Erin Oldenhof et al.
Long-term use of benzodiazepines and Z-drugs (collectively known as benzodiazepine receptor agonists; BZRAs) is associated with a range of adverse effects including dependence and withdrawal on stopping or reducing the dose. Deprescribing i...