Hanna Nørgaard Tuxen,Laila Zwisler,Allan Linneberg
Hanna Nørgaard Tuxen
Vitamin K was discovered during the 1930s when a strange haemorrhagic disorder was observed in chickens fed a cholesterol-free diet. A fat-soluble agent, present in green leafy vegetables and hog liver, was able to restore haemostasis in th...
TRPA1 Regulates Fibrosis-Associated Transcriptional Pathways in Human Lung Epithelial Cells [0.03%]
TRPA1调节人肺上皮细胞中与纤维化相关的转录途径
Leevi Halonen,Samu Luostarinen,Ida Valjus et al.
Leevi Halonen et al.
Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recent...
Deprescription of Psychotropics in Children and Adolescents: Systematic Review of Guidelines and Development of a Deprescribing Algorithm [0.03%]
儿童和青少年精神病药物的减停药处理：指南系统综述及减停药流程图开发
Paul-Benoît Fargier,Mark Horowitz,Rodolphe Charles et al.
Paul-Benoît Fargier et al.
Background: Psychotropics are increasingly prescribed in paediatrics despite limited evidence regarding their benefits and effectiveness. Although deprescribing approaches are established in adults, structured paediatric ...
Technology-Driven Decision Support for Opioid Tapering: A Scoping Review [0.03%]
基于技术的阿片类药物减量决策支持：系统综述
Laurits Valberg Hemmingsen,Lærke Karner Overgaard,Uffe Kock Wiil et al.
Laurits Valberg Hemmingsen et al.
Background: General practitioners manage most opioid tapering. This process requires time-consuming, individualised planning accounting for patient preferences, dose options and costs. Consequently, clinicians need tools ...
Jan Schjøtt,Leonora Onarheim Bergsjø,Ylva Böttiger
Jan Schjøtt
Investigation of the Effects of Perfluorooctane Sulfonic Acid (PFOS) and Perfluorooctanoic Acid (PFOA) Exposure on Interleukin-17 Signalling and Poly(I:C)-Induced Lung Inflammation in BALB/c Mice [0.03%]
八氟戊烷磺酸和全氟辛酸对BALB/c小鼠 interleukin-17信号传导及poly(i:c)诱导的肺部炎症的影响研究
Eda Nur İnkaya,Seçil Karahisar Turan,Nurhayat Barlas
Eda Nur İnkaya
The aim of this study was to investigate the effects of co-exposure to perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on the IL-17-related immune responses and the Poly(I:C)-induced lung inflammation. A total of 66 a...
Chemokines in Alzheimer's Disease: Early Defence, Late Damage and the Impact of Sex and Infection [0.03%]
阿尔茨海默病中的趋化因子：早期防御、晚期破坏以及性别和感染的影响
Blanca I Aldana,Kristine Freude
Blanca I Aldana
Chemokines constitute a versatile signalling network maintaining homeostasis and glia-neuron communication in the healthy brain but become progressively dysregulated during aging and Alzheimer's disease (AD). This review examines how chemok...
A Scoping Review of Dehydrozingerone in Preclinical Pharmacology: Activities, Dose Ranges and Toxicity [0.03%]
脱氢姜酮在临床前药理学中的作用、剂量范围和毒性的综述研究
Mikee C Mercado,Norazrina Azmi,Mazlina Mohd Said et al.
Mikee C Mercado et al.
Dehydrozingerone, a phenolic compound derived from ginger, has been reported to possess diverse pharmacological activities. This scoping review systematically evaluates the pharmacological and toxicological effects of dehydrozingerone and i...
Using Pharmacovigilance Data for Signal Detection of Drug Interactions for Rosuvastatin [0.03%]
来立信药物相互作用的信号检测——基于药品不良反应报告数据的研究
Ronja Levomäki,Päivi Hirvensalo,Aleksi Tornio et al.
Ronja Levomäki et al.
The 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitor rosuvastatin is a substrate of breast cancer resistance protein (BCRP). BCRP inhibition increases rosuvastatin plasma concentrations and may result in concentration-dependent mu...
Identifying Current Needs in Paediatric Pharmacoepidemiology: Insights From the NorPEN 2025 Workshop [0.03%]
儿科药物流行病学的当前需求识别：NorPEN 2025 工作shop 的见解
Elin Kimland,Rikke Wesselhoeft,Jenny Kindblom et al.
Elin Kimland et al.