Monoclonal Antibodies During Breastfeeding-Challenges With Relative Infant Dose [0.03%]
哺乳期间的单克隆抗体：相对婴儿剂量的挑战
Paulina Flis,Gro C Havnen,Elisabet Nordmo et al.
Paulina Flis et al.
Using Relative Infant Dose to Assess Drug Exposure in Breastfed Infants [0.03%]
采用相对婴儿剂量评估药物在母乳喂养婴儿中的暴露量
Olav Spigset
Olav Spigset
Antidepressants Use Among Pregnant Women in Denmark From 2001 to 2023: A Population-Level Drug Utilization Study [0.03%]
2001至2023年丹麦孕妇抗抑郁药使用情况的全国范围药物利用研究
Anne-Johanne Andersen,Kasper Nørlund Enevoldsen,Anne Sophie Enevoldsen et al.
Anne-Johanne Andersen et al.
We evaluated trends in antidepressant use among pregnant women in Denmark from 2001 to 2023, comparing them with a matched comparison group from the general population. Data from the Danish Health Data Authority were used to assess annual a...
Recurrent Exposure to Amoxicillin Impairs Male Reproductive Function by Enhancing Oxidative Stress and DNA Fragmentation in the Testis of Swiss Albino Mice [0.03%]
复方氨苄西林反复暴露通过提高氧化应激和小鼠睾丸DNA片段化损害雄性生殖功能
Nabila Akhtara,Manuj Kr Bharali,Mrinmoy Chakraborty et al.
Nabila Akhtara et al.
The present study was designed to investigate the impact of recurrent exposure to amoxicillin on the male reproductive system by employing a multi-parametric approach in a mouse model. Animals (n = 20) were randomly assigned into two groups...
The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation [0.03%]
药物通过泛素化修饰调节对CYP3A酶活性及蛋白质表达影响的研究
Fang Wang,Xiwei Gu,Haiying Hong et al.
Fang Wang et al.
Cytochrome P450 3A4 (CYP3A4) is one of the most important members of the cytochrome P450 subfamily, which is involved in the catalytic process of many drug activation or deactivation. Meanwhile, it is also a risk factor for drug-induced tox...
Sofie Voss Thorsen,Cille Bülow,Kim Dalhoff et al.
Sofie Voss Thorsen et al.
This scoping review investigates the association between ABCB1 polymorphisms and antidepressant efficacy in humans. A systematic search identified 630 records, of which 58 met the inclusion criteria, resulting in 42 unique studies (five ran...
How Is Psychotropic Use for Challenging Behaviour in People With Intellectual Disability Understood by Stakeholders? A Concept Analysis Using Rodgers' Evolutionary Approach [0.03%]
利益方是如何理解智力障碍人士挑战性行为的精神活性物质使用问题？一种运用Rodgers进化方法的概念分析
Dervla Kelly,Susan Morrissey,Darragh O&#x;Regan et al.
Dervla Kelly et al.
Psychotropic use for challenging behaviours in people with intellectual disability persists despite initiatives and prescribing guidelines encouraging judicious use. The use of some medications, such as psychiatric medications, can be stigm...
Insights Into Pharmacist-Led Deprescribing of Benzodiazepines and Related Drugs: A Qualitative Study With Physicians and Pharmacists [0.03%]
药师主导的苯二氮卓类和相关药物去处方的见解：与医师和药师的定性研究
Miro Korppas,Miia Tiihonen,Marika Buch Lund et al.
Miro Korppas et al.
While deprescribing benzodiazepines and related drugs (BZRDs) is crucial for preventing prolonged use and their associated adverse effects, it presents challenges from a healthcare perspective, because of limited resources and time. Recentl...
Pleural Effusion Formation Linked to Altered Transporter Expression Involved in Alveolar Fluid Clearance: Insights From the Monocrotaline Model of Pulmonary Hypertension [0.03%]
与参与肺液清除的转运蛋白表达改变相关的胸腔积液形成：来自单腹特碱诱导肺动脉高压模型的启示
Katarina Lelkova,Katarina Hadova,Michaela Katanova et al.
Katarina Lelkova et al.
Pleural effusions (PLEF) in pulmonary arterial hypertension (PAH), particularly in patients with isolated right heart failure, are associated with poor prognosis and increased mortality. This study investigates changes in alveolar fluid cle...