Hyperfiltration and Metabolism Before and After a Low-Calorie, Pre-Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs [0.03%]
低卡路里胃旁路手术前后的血液透析和代谢：对亲水性和亲脂性药物浓度的意义
Magnus A B Axelsson,Susanna M Wallerstedt
Magnus A B Axelsson
Psychotropic drug concentrations increase/decrease with hydrophilicity/lipophilicity after a low-calorie pre-bariatric surgery diet. To investigate underlying mechanisms, body weight and serum creatinine/cystatin C changes over the diet per...
Retrospective Analysis of the Use of Oral Ivermectin and 5% Permethrin Cream in Galicia (Spain) [0.03%]
西班牙加利西亚口服伊维菌素和5％塑料 cream 的使用回顾性分析
S Vazquez-Prieto,A Vaamonde,E Paniagua
S Vazquez-Prieto
Significant Antispastic Effect of Combined Fasudil and Isosorbide Dinitrate on Internal Mammary Artery in Coronary Artery Bypass Grafting [0.03%]
fasudil联合硝酸异山梨酯预防冠脉旁路移植术内乳内动脉痉挛的协同作用研究
You-Feng Zhang,Hai-Tao Hou,Qin Yang et al.
You-Feng Zhang et al.
Background: Vasospasm of arterial grafts remains a critical problem in coronary artery bypass grafting (CABG), contributing to perioperative ischemia and graft failure. This study evaluates the antispastic effects of comb...
Pernille Tveden-Nyborg,Troels K Bergmann,Niels Jessen et al.
Pernille Tveden-Nyborg et al.
Impact of Sex, Age, Body Composition and Kidney Function on the Relationship Between Self-Reported Alcohol Consumption and Phosphatidylethanol-Data From the HUNT Study [0.03%]
取酒消费与磷脂乙醇的关系受性别、年龄、身体成分和肾功能的影响——来自HUNT研究的数据
Ragnhild Bergene Skråstad,Øyvind Salvesen,Trine Naalsund Andreassen et al.
Ragnhild Bergene Skråstad et al.
Background: Phosphatidylethanol 16:0/18:1 (PEth) is a widely used alcohol marker, but how sex, body size and composition and kidney function affect the dose-response relationship between alcohol consumption and PEth is no...
Exosomes in Cardiovascular Disease: Emerging Roles, Therapeutic Potential and Translational Challenges [0.03%]
心血管疾病中的外泌体：新兴作用、治疗潜力和转化挑战
Adnan Taan Al Khafaji,Ali Mohammed Barakat,Akram Jooda Al Zaidy et al.
Adnan Taan Al Khafaji et al.
Cardiovascular diseases (CVDs) remain a leading global cause of mortality, necessitating novel therapeutic strategies to address myocardial injury, adverse remodelling and impaired cardiomyocyte regeneration. Exosomes, nanoscale extracellul...
Effect of Bariatric Surgery on the Pharmacokinetics of Codeine, Oxycodone and Tramadol-A Case Series [0.03%]
代谢手术对可待因、羟考酮和曲马多药代动力学的影响-病例系列报告
Olav Spigset,Hege-Merete Krabseth,Magnus Strømmen et al.
Olav Spigset et al.
Background: The impact of bariatric surgery on the pharmacokinetics of codeine, oxycodone or tramadol is largely unknown. Methods: In p...
Beyond Preservation: Propyl Gallate's Evolving Story as a Metabolic Precursor and Bioactive Compound [0.03%]
从防腐剂到代谢底物和生物活性物质增塑剂没食子酸正丙酯的进化故事
Woo Hyun Park
Woo Hyun Park
Propyl gallate (PG), a long-standing synthetic antioxidant, is integral to the food, cosmetic and pharmaceutical industries for its established effectiveness in inhibiting lipid peroxidation. This review synthesizes the evolving scientific ...
PGI Score: A Promising Alternative to Serum Cholinesterase for Predicting Mortality and Adverse Outcomes in Acute Organophosphorus Poisoning: A Cross-Sectional Study [0.03%]
PGI评分在急性有机磷中毒患者中预测病死率及不良预后中的应用：一项横断面研究
Ghada Attia Sagah,Fatma Gaber Sobeeh,Esraa Hamdy Nassar et al.
Ghada Attia Sagah et al.
Poisoning from organophosphorus compounds (OPCs) poses a significant health issue, especially in countries without proper testing facilities, including cholinesterase (ChE) levels. This study aimed to evaluate the effectiveness of a three-e...
GMI, a Fungal Immunomodulatory Protein From Ganoderma microsporum, Induces Different Cytotoxicity in Parental and Osimertinib-Resistant EGFR-Mutated Lung Cancer Cells via Apoptotic and Autophagic Cell Death [0.03%]
微小裸囊虫草菌免疫调节蛋白GMI通过凋亡和自噬诱导亲本细胞和奥希替尼耐药EGFR突变肺癌细胞产生不同的细胞毒性
Yu-Ting Kang,I-Lun Hsin,Pin-Tzu Su et al.
Yu-Ting Kang et al.
Lung adenocarcinoma often carries driver mutations, such as EGFR mutations, which are effectively targeted by EGFR tyrosine kinase inhibitors (EGFR-TKIs) like osimertinib, a third-generation EGFR-TKI approved for treating T790M and other EG...