Chelation Therapy for Rare Earth Element Toxicity: Current Evidence, Challenges and Future Directions [0.03%]
稀土元素中毒螯合治疗的现状、挑战与未来方向
Jose L Domingo
Jose L Domingo
The accelerating integration of rare earth elements (REEs) in advanced technologies has generated rising concern over human exposure and the attendant toxicological risks. This review presents an up-to-date synthesis of current evidence on ...
In Vivo and In Silico Dissection of Triclosan-Induced Reproductive Toxicity: Protective Potentials of Nanoselenium and Phytotherapy [0.03%]
三氯生致生殖毒性的体内和体外机制及其纳米硒和中草药干预效果研究
Marwan A Ibrahim,Barga Aboukhezam,Fayzah A Aboubakr et al.
Marwan A Ibrahim et al.
Triclosan (TCS) is a widely used antimicrobial agent raising concern about its potential toxicity and adverse effects on fertility. This study investigated the protective efficacy of clomiphene citrate, conventional selenium, nanoselenium a...
Perspectives on the Influence of Pharmaceutical and MedTech Companies on Deprescribing Decisions and Conference Sponsorship: A Survey Study [0.03%]
关于药企和医疗科技公司对减药决策及会议赞助影响的观点：一项调查研究
Katharina Tabea Jungo,Cynthia M Boyd,Barbara Farrell et al.
Katharina Tabea Jungo et al.
Background: The involvement and sponsorship of pharmaceutical and medical technology (MedTech) companies in deprescribing and medication optimization activities raise questions about conflicts of interest. We surveyed reg...
Assessing Condition-Specific Adverse Event Profiles of Modafinil for Labelled and Off-Label Uses: A Systematic Review and Meta-Analysis [0.03%]
莫达非尼标示和非标示适应症不良事件状况的系统评价和meta分析
Jaehee Jung,Jaeyoon Youm,Jihyun Kang et al.
Jaehee Jung et al.
Modafinil is approved for excessive daytime sleepiness in narcolepsy, obstructive sleep apnoea (OSA), and shift work sleep disorder (SWSD), but its widespread off-label use raises safety concerns. We evaluated the risk of adverse events (AE...
7,8-Dihydroxyflavone Suppresses Experimental Pulmonary Fibrosis by Inhibiting Fibroblast-to-Myofibroblast Transformation and Epithelial-Mesenchymal Transition [0.03%]
7,8-二羟基黄酮通过抑制成纤维细胞向肌成纤维细胞转化和上皮间充质转化来抑制实验性肺纤维化
Yu-Chen Song,Qing-Liu Li,Ru-Jin Liang et al.
Yu-Chen Song et al.
Pulmonary fibrosis (PF) is a chronic and progressive fibrotic disease with limited treatment options, which highlights the urgent need for novel therapeutic strategies. Fibroblast-to-myofibroblast transformation (FMT) and epithelial-mesench...
Reducing Anticholinergic Burden in Hospitalised Older Adults: Analysis From the INFAR Study [0.03%]
INFAR研究中住院老年患者的抗胆碱能负荷下降分析
Romana Santos Gama,Luiz Carlos Passos,Welma Wildes Amorim et al.
Romana Santos Gama et al.
This study aimed to evaluate the effectiveness of pharmacist-led medication reviews in reducing the anticholinergic burden of hospitalised patients with cardiovascular diseases (CVDs), to identify which anticholinergic medications were most...
Gadoteric Acid Induces Dose-Dependent DNA Damage and Enzyme Binding in Fibroblast Cells [0.03%]
gadoteric酸剂量依赖性地损害成纤维细胞的DNA并改变酶与DNA的结合
İbrahim Halil Kenger
İbrahim Halil Kenger
Gadolinium-based contrast agents, widely used in magnetic resonance imaging, raise safety concerns due to their potential cytotoxic and genotoxic effects, especially at high doses or repeated exposures. In this study, the cytogenotoxic pote...
Managing Delayed or Missed Doses of Prolonged-Release Tacrolimus in Transplant Recipients: Implications for Drug Exposure and Recovery Strategies [0.03%]
移植受者延迟或漏服他克莫司缓释制剂的处理：对药物暴露和恢复策略的影响
S Arraki Zava,F Maizaud,H Sayadi et al.
S Arraki Zava et al.
In lifelong immunosuppressive therapy, missed doses of prolonged-release tacrolimus are almost inevitable and may reduce drug exposure, compromising transplant outcomes. Using pharmacokinetic models, we simulated delayed and missed doses in...
Proton Pump Inhibitors and Biomarkers of Haemostasis in Postmenopausal Women: The Buffalo OsteoPerio Study [0.03%]
布法罗骨牙结合研究中绝经后女性质子泵抑制剂与凝血标志物的关系
Ahmed I Soliman,Jean Wactawski-Wende,Amy E Millen et al.
Ahmed I Soliman et al.
Aims: Examine the association between proton pump inhibitor (PPI) use and plasma levels of four biomarkers of haemostasis: fibrinogen, von Willebrand factor (vWF), high-sensitivity CRP (hs-CRP) and plasminogen activator i...
Epigallocatechin-3-Gallate Provides Hepatoprotection Through Endoplasmic Reticulum Stress/TXNIP/NLRP3 Axis in Paracetamol-Induced Acute Liver Injury [0.03%]
没食子儿茶素单棓酸通过内质网应激/TXNIP/NLRP3轴在对乙酰氨基酚诱导的急性肝损伤中发挥肝脏保护作用
Nagihan Demirtas,Busra Sahin Mazlumoglu,Nevra Aydemir Celep et al.
Nagihan Demirtas et al.
Epigallocatechin-3-gallate (EGCG) is a polyphenolic compound with strong antioxidant properties and is abundantly found in green tea. We investigated how EGCG affects the liver injury of high-dose paracetamol in this study. In our study, 56...