Healthcare Providers' Perspectives on Antidepressant Discontinuation: A Focus Group Study [0.03%]
抗抑郁药断药的医务人员观点：一项焦点小组研究
S Bouarfa,Wilma Göttgens,Suzanne A Ligthart et al.
S Bouarfa et al.
Antidepressant (AD) discontinuation in long-term users can be challenging for both patients and healthcare providers (HCPs). Better understanding of how HCPs handle this challenge is needed to improve discontinuation care. Therefore, we ide...
Deprescribed or Discontinued? Addressing Terminology Misinterpretation in Research [0.03%]
减少还是停药？解决研究中的术语误解问题
Caroline Sirois,Alexandre Campeau Calfat,Justin P Turner
Caroline Sirois
TCA Cycle Intermediate Mitigates Di(2-ethylhexyl) Phthalate-Induced Cholestatic Liver Injury Through Modulation of the Nrf2/NQO1 Signalling Axis [0.03%]
富马酸通过调控Nrf2/NQO1信号轴缓解Di(2-乙基己基)邻苯二甲酰胺诱导的胆汁淤积性肝损伤
Yue Jiang,Fang Xie,Xutao Ling et al.
Yue Jiang et al.
As a commonly used phthalate compound, di(2-ethylhexyl) phthalate (DEHP) has been shown to disrupt the tricarboxylic acid (TCA) cycle and aggravate tissue damage. However, whether the TCA cycle is involved in cholestatic liver injury (CLI) ...
Rutin-Associated Hepatoprotection: A Review of Mechanisms and Therapeutic Prospects [0.03%]
rutin肝保护作用机制及治疗潜力研究综述
Yanting Feng,Lanchun Peng,Xiaohui Liu et al.
Yanting Feng et al.
Background: Liver disorders pose a considerable global health challenge, accompanied by rising mortality rates. Current therapeutic strategies, though effective, often face limitations due to adverse effects and therapeut...
The Potential Ability of Betulinic Acid to Prevent Experimentally Induced Acute Pancreatitis in Rats [0.03%]
白桦酸预防急性实验性胰腺炎的作用及机制研究
Guler Yenice,Seckin Ozkanlar,Ismail Bolat et al.
Guler Yenice et al.
Acute pancreatitis (AP) is a serious pancreatic inflammatory disease that results in pancreatic enzyme activation and autodegradation. Betulinic acid (BA), a pentacyclic triterpene of natural origin that was isolated from several plants, ha...
Differences in the Inflammatory Response and Corticoid Responsiveness of Human Lung Macrophages and Parenchymal Explants Exposed to Cigarette Smoke Extracts [0.03%]
人肺巨噬细胞和实质组织外植体暴露于香烟烟雾提取物后的炎症反应及皮质激素反应性差异
Marion Brollo,Quentin Marquant,Hélène Salvator et al.
Marion Brollo et al.
Smoking is the main cause of chronic obstructive pulmonary disease (COPD) and is associated with corticosteroid resistance. Given the paucity of data on human lung preparations, macrophages (LMs), and parenchymal explants (LPEs) were expose...
Poisonings With Opioids and Benzodiazepines in Denmark: A Retrospective Study From the Danish Poison Information Centre [0.03%]
丹麦阿片类和苯二氮卓类药物中毒的回顾性研究：来自丹麦中毒信息中心的数据
Alba K V Sigfredsson,Dorte Fris Palmqvist,Kim Dalhoff
Alba K V Sigfredsson
Introduction: This study describes opioid and benzodiazepine poisonings in Denmark from 2014 to 2022. The analgesic effect of opioids and sedative effect of benzodiazepines are used to treat pain, insomnia and anxiety dis...
Observational Study
Basic & clinical pharmacology & toxicology. 2025 Jun;136(6):e70044. DOI:10.1111/bcpt.70044 2025
Emergency Department Visits due to Medication Overdose in a Finnish University Hospital [0.03%]
芬兰大学医院因药物过量而就诊的急诊病例
Sami Mustajoki,Aleksi Reito,Kalle Peltonen
Sami Mustajoki
There are no recent reports from the Nordic countries describing emergency department (ED) visits due to medication overdose. All patients visiting EDs of Tampere University Hospital, Finland, with ICD-10 codes T36-T50.9 during the year of ...
Preparing the Future of Research on Deprescribing: Results From a Survey of Early Career Researchers at the 2nd International Conference on Deprescribing [0.03%]
未来戒断用药研究人才培养：第二届国际戒断用药大会青年学者调查结果分析
Jérôme Nguyen-Soenen,Thomas Morel,Kristie Rebecca Weir
Jérôme Nguyen-Soenen