Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models [0.03%]
缺血性心脏病的冠状微血管功能障碍：大型动物模型的经验教训
Oana Sorop,J van de Wouw,Daphne Merkus et al.
Oana Sorop et al.
The coronary microvasculature is principally responsible for matching coronary blood flow to myocardial demand of oxygen and nutrients. Short-term control of coronary blood flow is achieved via alterations in coronary microvascular tone, wh...
Use of Potentially Inappropriate Medications Identified by STOPPFrail Among Danish Care Home Residents: A Nationwide Drug Utilisation Study [0.03%]
丹麦护理机构居民使用STOPPFrail判定的潜在不适当药物的利用情况——一项全国性药物利用研究
Katrine Mose,Carina Lundby,Martin Thomsen Ernst et al.
Katrine Mose et al.
Care home residents represent a frail population with limited life expectancy and are often prescribed multiple medications. As therapeutic goals shift in this population, certain treatments may become inappropriate. This study aims to desc...
A New Method for Antispastic Effect in Coronary Artery Bypass Grafts by Using a L- and T-Type Calcium Channel Blocker Efonidipine [0.03%]
新型抗痉挛药物乙酚芹idine(L型及T型钙通道阻滞剂)用于冠状动脉旁路移植心肌桥段以减少桥血管痉挛的实验研究
Xiu-Yun Yin,Hai-Tao Hou,Ming-Rui Li et al.
Xiu-Yun Yin et al.
Background: Internal mammary artery (IMA) is the most commonly used graft in coronary artery bypass grafting (CABG). Spasm of the IMA is a long-recognized problem with the reported prevalence of 0.43% in all CABG surgery....
Differences in mRNA Expression of Selected Cytochrome P450, Transporters and Nuclear Receptors Among Various Rat Models of Metabolic Syndrome [0.03%]
大鼠代谢综合征模型中选择性细胞色素P450、转运体和核受体的mRNA表达差异研究
Jan Soukop,Zuzana Rácová,Ludmila Kazdová et al.
Jan Soukop et al.
Metabolic syndrome (MetS) is a cluster of risk factors that increase the likelihood of developing cardiovascular, metabolic and other diseases. The pharmacological management of MetS often involves polypharmacy, making it essential to under...
Review of the Delay of Chronic Kidney Disease Progression by Wuling San on Improving Renal Fibrosis [0.03%]
五苓散延缓慢性肾脏病进展改善肾纤维化的研究进展
Zhijun Zeng,Beini Lao,Ke Liu et al.
Zhijun Zeng et al.
Renal fibrosis is a common pathological process in chronic kidney disease (CKD), which is mainly characterized by glomerulosclerosis and tubulointerstitial fibrosis. The formation and development of renal fibrosis are stimulated by pro-infl...
Limited Sampling Strategies to Predict Mycophenolic Acid and Tacrolimus Area Under the Concentration-Time Curve in Steroid-Free Kidney Transplant Patients [0.03%]
有限采样策略用于预测无激素肾脏移植受者的霉酚酸和他克莫司下的浓度时间曲线面积
Katrine Agergaard,Helle C Thiesson,Jan Carstens et al.
Katrine Agergaard et al.
This study aimed to develop limited sampling strategies to predict oral mycophenolic acid (MPA) exposure from one to three blood samples in stable steroid-free kidney-transplanted patients and assess if the same scheme could predict tacroli...
p-Cresol and p-Cresyl Sulphate Boost Oxidative Stress: A Systematic Review of Recent Evidence [0.03%]
对乙基酚和对甲苯磺酸盐加重氧化应激：近期证据的系统综述
Rinvil Renaldi,Tjhin Wiguna,Antonio M Persico et al.
Rinvil Renaldi et al.
Recent studies have emphasized the significant role of p-cresol and its conjugated form, p-cresyl sulphate (PCS), in enhancing oxidative stress, leading to potential detrimental effects on various biological systems. Both p-cresol and PCS c...
Long-Term Safety and Efficacy of AAV9 Vectors Expressing Human SMN1 Gene: A Preclinical Study [0.03%]
一种新型AAV9载体介导的SMN基因长期安全性和有效性的非人灵长类动物模型研究
Vahid Mansouri,Maryam Bemanalizadeh,Naser Ahmadbeigi et al.
Vahid Mansouri et al.
Spinal muscular atrophy (SMA) is a severe genetic neuromuscular disorder caused by deletions or mutations in the SMN1 gene, leading to reduced levels of the survival motor neuron (SMN) protein. Gene therapy using adeno-associated virus sero...
'This Is My Decision': A Qualitative Study of Individuals' Perspectives on Use of Semaglutide for Weight Loss [0.03%]
“这是我自己的决定”——利拉鲁肽减重使用的定性研究视角
Trine Graabæk,Nini Thi Nguyen,Malene Svoldgaard Sørensen et al.
Trine Graabæk et al.
Individuals using semaglutide for weight loss constitute a new, sizeable patient group, yet limited qualitative research of this group exists. Therefore, we explored their perspectives, including motivation for treatment, attitudes towards ...
High Economic Burden Yet Low Clinical Value: Why Is so Much Sucralfate Prescribed? [0.03%]
经济负担高但临床价值低：为什么那么多患者在使用硫糖铝？
Neha Wadhavkar,Laura Varnum,Steven F Moss
Neha Wadhavkar
Sucralfate is a commonly prescribed medication in use for decades. Despite the availability of more effective medications for acid-dyspeptic conditions, including proton pump inhibitors and histamine H2-receptor antagonists, sucralfate cont...