LW-AFC Protects Against Neurological and Neuropsychiatric Effects of SARS-CoV-2 Spike Protein in Mice [0.03%]
LW-AFC保护小鼠免受SARS-CoV-2刺突蛋白引起的神经和神经精神症状
Wenyi Xiao,Jiao Wang,Jianhui Wang et al.
Wenyi Xiao et al.
Numerous clinical studies show that besides respiratory symptoms, COVID-19 patients frequently undergo neurological and neuropsychiatric problems. However, effective treatments for these problems remain insufficient. LW-AFC, derived from tr...
Triterpenoid From Persimmon Leaves (Diospyros kaki L.f.) Exerted Anti-Type 2 Diabetic Effects and No Toxicity in Experimental Animals [0.03%]
柿树叶三萜具有良好的降血糖作用及较低的毒性
Hung Van Nguyen,Ha Thu Thi Nguyen,Nhan Trong Le et al.
Hung Van Nguyen et al.
The acute and subchronic toxicity, along with the anti-type 2 diabetic effects, of a triterpenoid extract from persimmon leaves (Tri DKL) was evaluated in animals. Acute oral toxicity was assessed in Swiss mice, whereas subchronic toxicity ...
The Role of Hydroxychloroquine in the Management of Rheumatic Disorders: A Comprehensive Review [0.03%]
羟氯喹在风湿性疾病管理中的作用：综合回顾
Ilker Ates,Hilal Sahin,Lalu Muhammad Irham et al.
Ilker Ates et al.
A drug preferred for its antimalarial effect called hydroxychloroquine (HCQ) has long been used to manage and avoid malaria. Nevertheless, its exact mode of action is still unknown. HCQ works through a variety of strategies to influence dis...
Huoxin Pill Ameliorates Atrial Fibrillation by Modulating Autonomic Nervous Balance and Electrical Conduction Heterogeneity: Insights From Systems Pharmacology and Experimental Validation [0.03%]
化薪颗粒通过调控自主神经平衡及电传导异质性治疗房颤：系统药理学与实验研究新见
Mimi Huang,Lingli Wang,Zejun Xu et al.
Mimi Huang et al.
Huoxin Pill (HXP), a traditional Chinese medicine for cardiovascular diseases, demonstrates clinically reported anti-atrial fibrillation (AF) effects, though its mechanisms remain unclear. To investigate these mechanisms, we established an ...
Blood Pressure-Lowering Effects of Aldosterone Synthase Inhibitors-A Systematic Review [0.03%]
盐皮质激素受体拮抗剂降压作用的系统性回顾
Anders Almskou Rasmussen,Ketil Lehm Nordestgaard,Ulf Simonsen et al.
Anders Almskou Rasmussen et al.
Excess aldosterone production contributes to the development of hypertension and results in fibrosis with dysfunction of the heart, vasculature and kidneys. Consequently, new agents have been developed to reduce endogenous aldosterone synth...
Antioxidant, Antiinflammatory and Antiapoptotic Effects of Lycopene in Rats With Vancomycin-Induced Nephrotoxicity [0.03%]
番茄红素对万古霉素致肾毒性的抗氧化抗炎和抗凋亡作用
Hülya Demirkapı Atik,Orkun Atik,Recep Aslan et al.
Hülya Demirkapı Atik et al.
Background: The most important side effect of vancomycin (Vanco) is nephrotoxicity (NPT). Lycopene (Lyco) has been reported to have anti-inflammatory and anti-apoptotic properties in addition to its antioxidant activity. ...
Efficacy and Safety of Clopidogrel With and Without a Proton Pump Inhibitor: A Systematic Review and Meta-Analysis [0.03%]
含氯吡格雷的治疗方案中联用和不联用质子泵抑制剂的有效性和安全性：系统性回顾和meta分析
Magnus A B Axelsson,Naldy Parodi López,Eva Wikström Jonsson et al.
Magnus A B Axelsson et al.
Classifications of drug interaction alerts regarding clopidogrel and a proton pump inhibitor (PPI) differ between knowledge resources. In this systematic review, Medline, Embase, and the Cochrane Library were searched for randomized control...
New Monitoring Recommendations for Digoxin During the Last Decade Are Associated With Decreased Serum Digoxin Concentrations in Patient Samples [0.03%]
近十年来新的 digoxin 监测建议与患者样本中较低的血清 digoxin 浓度相关
Anders Larsson,Anna-Karin Hamberg,Jonathan Cedernaes et al.
Anders Larsson et al.
Digoxin has long been used to manage atrial fibrillation and heart failure. While therapeutic drug monitoring (TDM) became available in the late 1960s, recent studies suggest increased mortality at serum levels > 1.0 ng/mL, prompting reasse...
Models of Endocrine-Disrupting Effects: Human Placental Steroidogenesis [0.03%]
内分泌干扰作用模型：人体胎盘类固醇激素生成作用
Line Mathiesen,Dea Sandal,Ida Elise Moelgaard Hammer et al.
Line Mathiesen et al.
Endocrine disruption during pregnancy has gained increasing interest as epidemiological studies report associations of exposures and adverse effects on fetal growth, followed by effects on the growing child and ultimately in the adult. When...
A Comprehensive Narrative Review of Protonitazene: Pharmacological Characteristics, Detection Techniques, and Toxicology [0.03%]
普鲁硝秦的综合叙述性回顾：药理特性、检测技术和毒理学
Jake Verbeek,David J Brinkman
Jake Verbeek
Protonitazene (PNZ) is a synthetic opioid emerging in Europe, Australia, North America and South America with a rapidly increasing number of intoxications. To describe PNZ's pharmacological characteristics, detection methods and the clinica...