Comparative Safety Analysis of Avastin and Bevacizumab Biosimilars Based on Food and Drug Administration Adverse Event Reporting System [0.03%]
基于美国食品药品管理局不良事件报告系统评估阿瓦斯汀与贝伐单抗相似药的安全性分析研究
Xiaoyu Zhang,Yupeng Zhang,Xinghang Tang et al.
Xiaoyu Zhang et al.
Objective: This study aimed to compare adverse event (AE) profiles between Avastin and bevacizumab biosimilars to support clinical decision-making, given the limited availability of real-world data. ...
Comparative Study
Basic & clinical pharmacology & toxicology. 2025 Oct;137(4):e70099. DOI:10.1111/bcpt.70099 2025
Multi-Target Renal Protection of Wine-Processed Polygonatum sibiricum Against Cisplatin-Induced Nephrotoxicity: Integrated Phytochemistry, Network Pharmacology and Experimental Validation [0.03%]
采用综合植物化学、网络药理学及实验验证评价的少白党参酒剂多靶器官保护肾毒性的研究：以顺铂致急性肾损伤为例
Yu Jiang,Wei Qiao,Kaili Guo et al.
Yu Jiang et al.
Acute kidney injury (AKI) is a serious complication of cisplatin chemotherapy, with limited treatment options. In this study, we investigated the protective effects of wine-processed Polygonatum sibiricum (WP. P. sibiricum) against cisplati...
Assessing the Carcinogenic Potential of PFOA: A Molecular Network Approach to Liver Toxicity [0.03%]
以分子网络为基础评估PFOA的致癌潜能及其肝毒性作用机制
Libi Tan,Tianyu She,Siyan Huo et al.
Libi Tan et al.
Perfluorooctanoic acid (PFOA), a prototypical per- and polyfluoroalkyl substance (PFAS), is widely used in industrial and consumer products but is classified as a Group 1 carcinogen by the IARC due to its environmental persistence and bioac...
Maternal Exposure to Medications and the Risk of Congenital and Early-Onset Hearing Loss in Children: A Systematic Review and a Meta-Analysis [0.03%]
母亲用药与儿童先天性和婴儿期听力损失风险的相关性：系统评价和 meta 分析
Asli Sena Kücükyildiz,Mette Østergaard Thunbo,Christer Zøylner Swan et al.
Asli Sena Kücükyildiz et al.
Background: Congenital hearing loss (CHL) affects approximately 1-2 in 1000 children and significantly impacts development. Exposure to medications during pregnancy may impact offspring hearing; however, the ototoxic effe...
Development of a Deprescribing Intervention for Proton Pump Inhibitors in Primary Care: A Co-Design Approach With General Practitioners and Patients [0.03%]
与全科医生和患者共同设计开发 primary care中 proton pump inhibitors的减药干预措施
Kristie Rebecca Weir,Clémentine Tombez,Yvonne Mattmann et al.
Kristie Rebecca Weir et al.
Proton Pump Inhibitors (PPIs) are widely prescribed medications globally. PPIs are often inappropriately used - for example, prescribed without a clear indication, at higher-than-necessary doses, or for longer durations than needed - result...
Discontinuing Chronic Medications Suggested for Deprescribing in Routine Clinical Practice: Nationwide Evidence From Routinely Collected Data in Swedish Older Adults [0.03%]
来自瑞典老年人常规收集数据的全国证据：建议停止常规临床实践中慢性药物的长期使用
Karl-Hermann Sielinou Kamgang,Carina Lundby,Máté Szilcz et al.
Karl-Hermann Sielinou Kamgang et al.
Background: National estimates of drug discontinuation for deprescribing targets in older adults are limited, partly due to challenges distinguishing planned deprescribing from poor adherence. Focusing on individuals with...
Special Collection: Mechanisms of Vasodilatation Endothelium-Dependent Hyperpolarization (MOVD/EDH2024) [0.03%]
专题收编：内皮细胞依赖性血管舒张机制（EDH/MOVD 2024）
Christopher J Garland
Christopher J Garland
Correction to 'Β-LAPachone Ameliorates Doxorubicin-Induced Cardiotoxicity via Regulating Autophagy and Nrf2 Signalling Pathways in Mice' [0.03%]
关于“β- lapachone通过调节自噬和nrf2信号通路改善多柔比星致小鼠心脏毒性的研究”的更正通知
Published Erratum
Basic & clinical pharmacology & toxicology. 2025 Sep;137(3):e70089. DOI:10.1111/bcpt.70089 2025
Assessment of Rivaroxaban Plasma Concentration Using Chromogenic Anti-Xa Assays and UHPLC-MS/MS in Chinese Patients With Atrial Fibrillation [0.03%]
在房颤患者中使用色谱法和UHPLC-MS / MS测定达比加群酯血浆浓度的评估研究
Xiao-Qin Liu,Yi Gu,Yu-Fei Zhang et al.
Xiao-Qin Liu et al.
Accurate quantification of rivaroxaban concentration is essential in some specific clinical situations. A prospective study was conducted to compare the rivaroxaban concentration measured by Zhenyuan anti-Xa assay with that by reference met...
Comparative Study
Basic & clinical pharmacology & toxicology. 2025 Sep;137(3):e70088. DOI:10.1111/bcpt.70088 2025
Xiao-Jie-An Capsule Alleviates Uterine Fibroids by Modulating Oestrogen-Progesterone Balance and Reducing Inflammatory Response [0.03%]
调经消癓胶囊通过调节雌孕激素平衡及降低炎症反应治疗子宫肌瘤
Yi Ying,Jihan Liu,Shanshan Ju et al.
Yi Ying et al.
Uterine fibroids (UF) are benign tumours composed of smooth muscle cells and fibrous connective tissue. UF are common among women aged 30-50 years and often present with symptoms such as anaemia, pelvic pain and bladder dysfunction. Xiao-Ji...