Endogenous Levels, Detection Time, and Symptoms of Gamma-Hydroxybutyric Acid: Results From a Placebo-Controlled Clinical Trial [0.03%]
γ-羟基丁酸内源性水平、检出时间和症状：一项安慰剂对照临床试验的结果
Kathrine Bohn Faldborg,Lambert Kristiansen Sørensen,Jørgen Bo Hasselstrøm et al.
Kathrine Bohn Faldborg et al.
Gamma-hydroxybutyric acid (GHB), a potential agent in drug-facilitated sexual assault, is difficult to detect due to rapid elimination, endogenous presence, and possible postsampling formation. We conducted a randomised, placebo-controlled ...
Randomized Controlled Trial
Basic & clinical pharmacology & toxicology. 2025 Dec;137(6):e70133. DOI:10.1111/bcpt.70133 2025
Medication-Related Admissions Among Older Patients in a Danish Emergency Department: Prevalence, Preventability and Characterisation [0.03%]
丹麦急诊科老年患者的药物相关住院情况：流行病学、可预防性和特征描述
Louise Westberg Strejby Christensen,Kim Peder Dalhoff,Esben Iversen et al.
Louise Westberg Strejby Christensen et al.
The prevalence of medication-related admissions (MRAs) among older medical patients admitted to Danish emergency departments (EDs) remains limited. We aimed to determine the prevalence of possibly medication-related admissions (PMRAs) in th...
Steffen Jørgensen,Ali Rezazada,Ali Hisani et al.
Steffen Jørgensen et al.
Bergaptol Alleviates Oxidative Stress and Inflammation in Intracerebral Haemorrhage Mice via JAK2/STAT3 and NF-κB Pathways, Improving Neurological Function [0.03%]
伯格木醇通过JAK2/STAT3和NF-κB途径缓解脑出血氧化应激及炎症反应改善神经功能损伤
Jianbing Wu,Zhangchao Guo,Xiaohuan He et al.
Jianbing Wu et al.
Background: Bergaptol has demonstrated various pharmacological activities, including antitumor, anti-inflammatory and neuroprotective effects. However, its therapeutic potential and underlying mechanisms in intracerebral ...
Pharmacokinetics of Double-Layer Patches With Microneedles Containing Procyclidine and Rivastigmine in Guinea Pigs [0.03%]
含PROCYLIDINE和rivastigmine的微针双层贴片在小豚鼠体内的药代动力学研究
Minsun Moon,Jihyun Won,Yun-Woo Lee et al.
Minsun Moon et al.
Reversible cholinesterase inhibitors have been investigated to address prophylactic and therapeutic outcomes against organophosphorus nerve poisoning, and procyclidine is concomitantly used to compensate for their adverse effects. We design...
Studying Deprescribing Using Routinely Collected Healthcare Data: Old Challenges and New Opportunities [0.03%]
利用常规医疗保健数据研究减药：老问题与新机遇
Jonas W Wastesson,Karl-Hermann Sielinou Kamgang,Carina Lundby et al.
Jonas W Wastesson et al.
Development of a Brief Mindfulness-Informed Cognitive-Behavioural Therapy Intervention to Pair With Pharmacist-Led Benzodiazepine Tapering for Older Adults: The CSTARS Intervention [0.03%]
一种简化的与认知行为疗法相关的正念干预措施与药剂师主导的苯二氮卓类药物减量相结合，针对老年人：CSTARS干预措施的发展
Kristen M Kraemer,Brianna Wang,Marissa McCann et al.
Kristen M Kraemer et al.
Benzodiazepines are potentially inappropriate medications for older adults, and deprescribing interventions are needed. We describe the development of a psychologist-led, mindfulness-informed cognitive-behavioural therapy (CBT) intervention...
Electrochemical Point-of-Care Test for Assessing Serum Paracetamol Concentration: Comparison With Traditional Methods and Detection of Concomitant Drugs [0.03%]
评估血清对乙酰氨基酚浓度的电化学生物传感器检测方法：与传统方法对比及伴随药物的检出能力
Johanna K Kujala,Terhi J Lohela,Niklas Wester et al.
Johanna K Kujala et al.
Rapid serum paracetamol (acetaminophen) concentration measurement is essential in suspected intoxication, but centralized laboratory analyses often delay initiation of antidotal therapy. We studied the feasibility of a novel electrochemical...
Comparative Study
Basic & clinical pharmacology & toxicology. 2025 Nov;137(5):e70127. DOI:10.1111/bcpt.70127 2025
Quality Assessment of Therapeutic Drug Monitoring Assays of Therapeutic Antibodies Across Europe: An Update [0.03%]
欧洲治疗性抗体治疗药物监测分析的质量评估：更新版
James Bluett,Merita Rumano,María José Martínez Becerra et al.
James Bluett et al.
Immune mediated inflammatory diseases (IMIDs) are common, chronic, inflammatory diseases. There has been an expansion of monoclonal antibodies to treat the disease. However, the response is not universal; reasons for non-response may includ...