Mandatory medication content in the curricula of six health care personnel types with patient contact in Denmark [0.03%]
丹麦六种接触患者的卫生专业人员课程中强制性药物内容的要求
Louise C Druedahl,Johanne Mølby Hansen,Ellen Linnea Freese et al.
Louise C Druedahl et al.
Medication use is a complex process involving different types of health care personnel. This study investigated and compared mandatory medication content in the curricula of six types of health care personnel with patient contact. Using con...
Comparative Study
Basic & clinical pharmacology & toxicology. 2019 Apr;124(4):431-438. DOI:10.1111/bcpt.13147 2019
Tricyclic antidepressant amitriptyline inhibits autophagic flux and prevents tube formation in vascular endothelial cells [0.03%]
三环类抗抑郁药阿米替林可抑制自噬流并阻碍血管内皮细胞管的形成
Yinglu Guan,Xiang Li,Michihisa Umetani et al.
Yinglu Guan et al.
Amitriptyline is a tricyclic antidepressant and an inhibitor of lysosomal acid sphingomyelinase (ASM). Amitriptyline is well known for its cardiovascular side effects and toxicity in psychiatric patients. However, the mechanisms underlying ...
Physicians' views on patient participation in choice of oral anticoagulants in atrial fibrillation-a qualitative study [0.03%]
房颤患者口服抗凝药选择中患者的参与程度——定性研究
Emma Aarnio,Risto Huupponen,Katri Hämeen-Anttila et al.
Emma Aarnio et al.
Direct oral anticoagulants provide an alternative to vitamin K antagonists for the anticoagulation therapy in atrial fibrillation (AF). The availability of several treatment options with different attributes makes shared decision-making app...
Stanozolol promotes lipid deposition in the aorta through an imbalance in inflammatory cytokines and oxidative status in LDLr knockout mice fed a normal diet [0.03%]
司坦诺唑醇通过促炎症细胞因子失衡和氧化应激致LDLR敲除小鼠正常饮食条件下腹主动脉脂质沉积增加
Tadeu Uggere de Andrade,Silvia Cruz Goes Coutinho Haguihara,Raiana Maria Prucoli Falsoni et al.
Tadeu Uggere de Andrade et al.
The aim of the study was to evaluate the effect of an anabolic steroid, stanozolol, in a model of atherosclerosis and to investigate the involvement of the modulation of the inflammatory cytokines and oxidative stress in vascular lipid depo...
Withdrawal from long-term use of zopiclone, zolpidem and temazepam may improve perceived sleep and quality of life in older adults with primary insomnia [0.03%]
长期使用唑吡坦、佐匹克隆和泰米巴帝治疗原发性失眠或可改善老年人群的睡眠感知及生活质量
Ritva Lähteenmäki,Pertti J Neuvonen,Juha Puustinen et al.
Ritva Lähteenmäki et al.
Long-term use of benzodiazepines or benzodiazepine receptor agonists is widespread, although guidelines recommend short-term use. Only few controlled studies have characterized the effect of discontinuation of their chronic use on sleep and...
Randomized Controlled Trial
Basic & clinical pharmacology & toxicology. 2019 Mar;124(3):330-340. DOI:10.1111/bcpt.13144 2019
Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects [0.03%]
与芬太尼药动学、药效学及不良反应相关的多态性分析
Miriam Saiz-Rodríguez,Dolores Ochoa,Coral Herrador et al.
Miriam Saiz-Rodríguez et al.
Fentanyl is an agonist of the μ-opioid receptor commonly used in the treatment of moderate-severe pain. In order to study whether pharmacogenetics explains some of the variability in the response to fentanyl, several genes related to fenta...
Discontinuation of antidepressants in suicides findings from the Friuli Venezia Giulia Region, Italy, 2005-2014 [0.03%]
2005年至2014年意大利弗留利威尼斯朱利亚大区自杀者中抗抑郁药物的停药现象及启示
Giulio Castelpietra,Luca Bortolussi,Michele Gobbato et al.
Giulio Castelpietra et al.
Although continued use of antidepressants (AD) has been found to be associated with a lower risk of suicide, AD discontinuation is reported repeatedly. The aim of this case-control study, thus, was to assess whether discontinuation to AD wa...
Using a semi-mechanistic model to identify the main sources of variability of metformin pharmacokinetics [0.03%]
利用半机制模型识别二甲双胍药代动力学变异的主要来源
Tore Bjerregaard Stage,Gustaf Wellhagen,Mette Marie Hougaard Christensen et al.
Tore Bjerregaard Stage et al.
Metformin pharmacokinetics (PK) is highly variable, and researchers have for years tried to shed light on determinants of inter-individual (IIV) and inter-occasion variability (IOV) of metformin PK. We set out to identify the main sources o...
The developmental basis of disease: Update on environmental exposures and animal models [0.03%]
发育的病因学：环境暴露与动物模型的新进展
Jerrold J Heindel
Jerrold J Heindel
At the Prenatal Programming and Toxicity (PPTox) Conference I in 2008, I presented an overview of the developmental origins of health and disease field focusing on environmental chemical exposures and disease outcomes. At that time, I noted...
A review of the Ghana National Health Insurance Scheme claims database: possibilities and limits for drug utilization research [0.03%]
加纳国家健康保险方案索赔数据库的回顾：药物利用研究的可能性和局限性
Daniel Ankrah,Jesper Hallas,James Odei et al.
Daniel Ankrah et al.
Background: There are inadequate data on prescribed drug utilization in Sub-Saharan Africa (SSA). Drug utilization research (DUR) in this region is hampered by lack of access to databases that capture prescribed drug util...