Antagonism of Kinin Receptors B1 and B2 Attenuates Folic Acid-Induced Tubulointerstitial Fibrosis in Mice [0.03%]
B1和B2激肽受体拮抗剂可减轻叶酸诱导的小鼠肾小管间质纤维化
Gabriel Rufino Estrela,Alexandre Budu,Juliene Silva et al.
Gabriel Rufino Estrela et al.
Chronic kidney disease (CKD) remains a significant global health burden despite recent advances in pharmacotherapy, including sodium-glucose cotransporter 2 (SGLT2) inhibitors and mineralocorticoid receptor antagonists. Renal fibrosis, a ce...
Sp1-Mettl14 Feedback Loop Promotes Ferroptosis in Mycobacterium tuberculosis-Infected Microglia by Activating Acsl4 [0.03%]
Sp1-Mettl14反馈环通过激活Acsl4促进结核杆菌感染的小胶质细胞铁死亡
Junhao Chu,Quansheng Liu,Xue Chen et al.
Junhao Chu et al.
Central nervous system tuberculosis (CNS-TB) represents a critical form of extrapulmonary tuberculosis, characterized by high mortality and morbidity. The infection of microglia by Mycobacterium tuberculosis (Mtb) is a crucial factor in the...
Fall Risk Awareness and Experiences Among Adult Users of Opioids in Denmark: A Community Pharmacy-Based Questionnaire Pilot Study [0.03%]
丹麦成人阿片类药物使用者的跌倒风险意识和体验：基于社区药房的问卷试点研究
Juliane Maria Rosendahl,Jesper Ryg,Carina Lundby
Juliane Maria Rosendahl
Metformin Attenuates ox-LDL-Induced Macrophage Senescence and Inflammation via NR4A1-Mediated Mitophagy Regulation [0.03%]
二甲双胍通过NR4A1介导的线粒体自噬调节缓解氧化低密度脂蛋白诱导的巨噬细胞衰老和炎症反应
Luling Li,Xiuting Huang,Pei Li
Luling Li
Metformin alleviates oxidized low-density lipoprotein (ox-LDL)-induced macrophage senescence, a key process in atherosclerosis. Our in vitro findings demonstrate that metformin suppresses ox-LDL-induced overexpression of the nuclear recepto...
Pharmacogenetic Predictors of Postoperative Opioid-Related Adverse Events: A Systematic Review [0.03%]
术后阿片类药物相关不良事件的药理遗传学预测因子：系统性回顾
Selma Pedersen Kjartansdóttir,Caroline Folkersen,Ida Houtved Rasmussen et al.
Selma Pedersen Kjartansdóttir et al.
Backgrounds/aims: This systematic review aimed to assess associations between genotypes and the risk of experiencing postoperative opioid-related adverse drug events (ORADEs). ...
Drug-Induced Liver Injury Associated With Moxifloxacin: A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System and a Real-World Retrospective Study [0.03%]
基于FDA不良事件数据库的莫西沙星所致药物性肝损伤的药物流行病学分析及真实世界回顾性研究
Yanqing Song,Chunzi Li,Xiaoyue Liu et al.
Yanqing Song et al.
Objective: While current studies have focused on the incidence of moxifloxacin-associated liver injury, risk factors and clinical characteristics for moxifloxacin-induced liver injury in hospitalized patients remain unexp...
Observational Study
Basic & clinical pharmacology & toxicology. 2026 Feb;138(2):e70187. DOI:10.1111/bcpt.70187 2026
A Clinical Medication Review Focused on Deprescribing in Older Patients With Hyperpolypharmacy: A Mixed-Methods Feasibility Study [0.03%]
针对高龄患者开展以停用和减用药物为主的临床用药审查的混合方法学可行性研究
Gert Baas,Mette Heringa,Sanne Verdoorn et al.
Gert Baas et al.
To address challenges in deprescribing, we investigated the feasibility of an intervention consisting of a clinical medication review (CMR) focused on deprescribing, supported by a training programme for healthcare providers (HCPs) among ol...
Hypersensitivity to Opioids: Prevalence, Mechanisms, Diagnosis and Management [0.03%]
阿片类药物过敏症的流行病学、机制、诊断和处理方法
Kenneth Skov,Eva Aggerholm Sædder,Gitte Krogh Madsen et al.
Kenneth Skov et al.
Many patients report being allergic to opioids and/or have allergy warnings documented in their medical records. However, the reasoning behind these warnings is often unclear and frequently lacks clinical validation. Reported reactions may ...
Development and Application of an LC-MS Method for the Pharmacokinetics and Pharmacodynamics of Oral Therapeutic Efficacy of Nalfurafine [0.03%]
纳鲁拉芬口服治疗有效性的药代动力学和药效学的LC-MS方法的研发与应用
Sven Sondhauss,Mackenzie Kiernan,Julia Morizzi et al.
Sven Sondhauss et al.
Multiple sclerosis (MS) is a chronic autoimmune disease characterized by central nervous system demyelination, leading to sensory and motor dysfunction. Previous studies have demonstrated that the kappa opioid receptor agonist nalfurafine (...
Investigating the Effects of Apilarnil on Vincristine-Induced Testicular Toxicity in Rats [0.03%]
阿匹拉奈尔对长春新碱致大鼠睾丸毒性的干预作用研究
Metin Takkaç,Serkan Ali Akarsu,Gamze Uçak et al.
Metin Takkaç et al.
Vincristine (VCR) is a common drug used for this purpose. Apilarnil is a substance known for its antioxidant, antidiabetic and chemoprotective properties with positive effects on the reproductive system. In this study, the effects of apilar...