Augmenting natural skin stretch during active finger motion reshapes hand proprioception [0.03%]
在手指运动期间增强自然皮肤拉伸可以重塑手部本体感觉
Eleonora Fontana,Alessandro Moscatelli,Manuel Giuseppe Catalano et al.
Eleonora Fontana et al.
There is strong evidence that skin stretch at the joint contributes to proprioception, the perceptual representation of body position and motion. Previous studies on fingers and hand dorsum focused on illusory movement elicited by skin-stre...
Glucosylceramide increases the mechanical resistance of membrane domains [0.03%]
糖基 ceramide 增加膜区域的机械阻力
Marina Placci,Silvia Muro,Marina Inés Giannotti
Marina Placci
Cells tightly regulate membrane composition to maintain homeostasis and adapt to perturbations. Disruptions in lipid metabolism, such as those occurring in Gaucher disease (GD), can disturb this balance. In GD, excess glucosylceramide (GlcC...
Order matters: how the sequence of sensitivity analysis, parameter identifiability and uncertainty quantification shapes model insights [0.03%]
顺序有讲究：敏感性分析、参数可识别性和不确定性量化如何决定模型的新见解
N G Cogan,Mohammad Nooranidoost,Meghan Peltier et al.
N G Cogan et al.
Mathematical models are essential tools for understanding biological systems, but their predictive value depends on how parameter uncertainty is handled. Three core approaches-uncertainty quantification (UQ), sensitivity analysis (SA) and p...
TiDHy: timescale demixing via hypernetworks to learn simultaneous dynamics from mixed observations [0.03%]
基于超网络的时间尺度解混以从混合观测中学习同时动态特性
Elliott Taylor Tsuyoshi Abe,Bingni W Brunton
Elliott Taylor Tsuyoshi Abe
Neural activity and behaviour arise from multiple concurrent time-varying systems, including neuromodulation, neural state and history; however, most current approaches model these data as one set of dynamics with a single timescale. Here, ...
Talyah M Nelson,Mona Eskandari
Talyah M Nelson
Pulmonary disease is a globally leading cause of morbidity and mortality, largely attributable to the lung's chronic particulate inhalation. Pervasive environmental hazards and, notably, habitual smoking produce inflammation and damage, con...
Thermal conductivity modulation as a mechanism of inducible thermotolerance in the eutardigrade Paramacrobiotus sp [0.03%]
热导调节机制在水熊虫属Paramacrobiotus压力下的诱导耐热性中的作用
Harikumar R Suma,Divya Vishnu,T Phanindra Sai et al.
Harikumar R Suma et al.
Many organisms, including tardigrades, can survive extreme conditions. However, the mechanisms underlying this extremotolerance remain unclear. Here, we demonstrate inducible thermotolerance in the eutardigrade Paramacrobiotus sp., linked t...
Synchrotron X-rays elucidate the intracellular storage of the iodide and bromide antioxidant system in the kelp Laminaria digitata [0.03%]
同步加速器X射线阐明了海带细胞内碘化物和溴化物抗氧化系统的储存机制
Frithjof C Küpper,Mijovilovich Ana,Peter Cloetens et al.
Frithjof C Küpper et al.
The kelp Laminaria digitata uses iodide as a unique inorganic antioxidant to protect its surface and apoplastic space, with implications for atmospheric and marine chemistry as well as regional climatic processes. However, until now, signif...
Damian Renggli,Maria Clara Novaes-Silva,Demetrios Laios et al.
Damian Renggli et al.
Phase separation in mixed lipid layers is used here to mimic crowding at interfaces, providing insights into the dynamics of (and within) phospholipid monolayers. The interface is fully fluid at temperatures above the liquid-condensed (LC) ...
Bio-informed blade patterns for mitigating bird collisions with wind turbines [0.03%]
生物信息叶片图案可降低鸟类与风力涡轮机相撞的概率
Caroline Helen Brighton,Steven J Portugal,Graham Keith Taylor
Caroline Helen Brighton
Although the rapid expansion of wind energy is essential for achieving carbon net zero targets, it may conflict with ecological objectives aimed at conserving and enhancing biodiversity. Birds in general are susceptible to colliding with wi...
Yuval Rabani,Leonard J Schulman,Alistair Sinclair
Yuval Rabani
We consider the dynamics imposed by natural selection on the populations of two competing, sexually reproducing, haploid species. In this setting, the fitness of any genotype varies over time due to the changing population mix of the compet...