Multi-sensor continuous-flow bioreactor for dynamic and scalable cell culture [0.03%]
用于动态和可扩展细胞培养的多传感器连续流生物反应器
Matthew James,Dennis Edmondson,Jason Samson et al.
Matthew James et al.
Bioreactors are essential tools in tissue engineering and advanced cell culture because they provide dynamic environments that support cellular growth, organization and tissue maturation. However, most existing systems lack integrated real-...
Myofibroblasts slow down defect recombination dynamics in mixed cell monolayers [0.03%]
肌成纤维细胞减慢了混合细胞单层中的缺陷重组动力学
Zhaofei Zheng,Yuxin Luo,Juan Chen et al.
Zhaofei Zheng et al.
Cellular organization and mechanotransduction pathways are crucial regulators of tissue morphogenesis, whereas their dysregulation contributes to pathologies. Overactive myofibroblasts are key drivers of fibrosis, yet how their presence alt...
Dissent enhances the credibility of groups of Bayesian conformist decision-makers [0.03%]
异议可以增强贝叶斯趋同决策者的团体可信度
Aurèle Boussard,Richard P Mann,Alfonso Pérez-Escudero
Aurèle Boussard
When making a decision, individuals use their private information to evaluate the available options. In a group, they can also learn from other group members' choices, which partially reveal their own private information. Bayesian estimatio...
Inflammatory factor transport drives macrophage aggregation in an in silico aneurysm inflammation model [0.03%]
基于计算机的动脉瘤炎症模型中的炎性因子传输驱动巨噬细胞聚集效应
Zhitian R Shi,Hadi Wiputra,Jesse W Williams et al.
Zhitian R Shi et al.
Inflammation plays an important role in the pathological remodelling and rupture of intracranial aneurysms. One of the challenges in predicting the prognosis of intracranial aneurysms lies in the variation of the inflammatory state in aneur...
From individual thresholds to collective hysteresis: a mechanistic model of the dawn chorus [0.03%]
从个体阈值到集体滞后现象：晨鸣的机制模型
Alexander R Kaye
Alexander R Kaye
At dawn, many bird communities exhibit a rapid and highly synchronous transition from silence to vocal activity. Although light levels increase gradually, the onset of this dawn chorus can appear abrupt, suggesting the possibility of tippin...
Kalman-filter force inference: an estimation framework for cellular forces from temporal evolution of epithelial morphogenesis [0.03%]
卡尔曼滤波力推断：上皮形态发生随时间演变的细胞力估计框架
Goshi Ogita,Takemasa Miyoshi,Tatsuo Shibata
Goshi Ogita
Epithelial morphogenesis is orchestrated by cellular forces, including cell junctional tension and cellular pressure. Elucidating their spatio-temporal dynamics is paramount for understanding morphogenesis during development. While various ...
Disruption of magnetic orientation in migratory songbirds by radiofrequency magnetic fields is mediated by a specialized sensory system [0.03%]
无线电频率磁场通过一种特化的感官系统干扰迁徙鸣鸟的磁导向能力
Kirill Kavokin,Julia Bojarinova,Dmitriy Sannikov et al.
Kirill Kavokin et al.
Direction finding in migratory birds is known to be affected by oscillating magnetic fields (OMFs) in the radiofrequency range. This experimental fact was earlier interpreted in terms of the direct influence of OMFs on electron spins in the...
Jinling Yan,Shao-Wu Zhang,Jifan Shi et al.
Jinling Yan et al.
Understanding causality is central to scientific discovery, importantly enabling the elucidation of mechanisms within complex systems. However, current methods of causal inference face significant challenges in uncovering interventional cau...
Non-viral protein shells with octahedral and tetrahedral symmetries and a theory of critical density waves [0.03%]
八面体和四面体对称性的非病毒蛋白壳及临界密度波理论
Olga V Konevtsova,Dmitrii V Chalin,Aleksey S Roshal et al.
Olga V Konevtsova et al.
Unlike viral capsids, which protect and transport genetic material, non-viral protein shells perform diverse biological functions, including enzymatic catalysis, iron storage and protein chaperone activity. These shells often exhibit tetrah...
A mathematical model for inflammation and demyelination in multiple sclerosis [0.03%]
多发性硬化症炎症和脱髓鞘的数学模型
Adrianne Jenner,Georgia Weatherley,Federico Frascoli
Adrianne Jenner
Multiple sclerosis (MS) is an incurable, life-long disease caused by the demyelination of neurons in the brain and spine. MS is often characterized by relapses in inflammation and demyelination, followed by periods of remission. Symptoms ca...