Bridging the gap: towards a digital twin to optimize therapeutic cell-seeding strategies in nerve tissue engineering [0.03%]
迈向数字孪生：优化神经组织工程中治疗性细胞播种策略的研究
Owein Guillemot-Legris,Maxime Berg,Poppy O Smith et al.
Owein Guillemot-Legris et al.
Peripheral nerve injuries impose a substantial strain on the lives of millions of people worldwide. Engineered neural tissues provide a promising avenue to improve peripheral nerve repair strategies, potentially allowing the precise seeding...
Mechanistic insights into Bluetongue virus immunodynamics: a Bayesian within-host modelling approach [0.03%]
蓝舌病病毒免疫动力学的机制见解：一种贝叶斯宿主内建模方法
Abhijit Majumder,Joseph A Westrich,Erin McNulty et al.
Abhijit Majumder et al.
Bluetongue virus (BTV) is a vector-transmitted orbivirus that infects ruminant livestock and wildlife, causing substantial economic losses owing to its impact on animal health and trade. Despite extensive study, the mechanisms underlying in...
Basement membrane turnover drivesfilopodial protease-independent invasion [0.03%]
基底膜转换驱动无蛋白酶参与的鸟足状伪足入侵
David Hernandez-Aristizabal,Anotida Madzvamuse,Frédéric Luton et al.
David Hernandez-Aristizabal et al.
Basement membranes (BMs) are specialized, nanoporous extracellular matrices (ECMs) mainly composed of collagen IV fibres and laminins. Because collagen IV fibres form covalent cross-links (CCLs), cells cannot freely cross BMs. BM breaching ...
Explainable machine learning reveals evolutionary signals in influenza haemagglutinin [0.03%]
解释性机器学习揭示了流感血凝素中的进化信号
Austin G Meyer
Austin G Meyer
Identifying amino acid changes that lead to phenotypic change is critical to viral surveillance. Common metrics, such as site-wise evolutionary rates and entropy, are true measures of variability rather than phenotypic importance. Here, I s...
Phase separation as a tunable regulator of canonical gene regulatory motifs [0.03%]
相分离作为经典基因调控元件的可调调节器
Priya Chakraborty,Mintu Nandi,Sandeep Choubey
Priya Chakraborty
Gene regulatory networks (GRNs) govern essential cellular processes, such as signal transduction, metabolism and cell fate control. The biophysical principles governing the dynamical behaviour of GRNs remain elusive. Recent studies highligh...
Savannah-forest dynamics: encroachment speed, model inference and spatial simulations [0.03%]
草原森林动态学：入侵速度、模型推理和空间模拟研究
Yuval R Zelnik,Ivric Valaire Yatat-Djeumen,Le Bienfaiteur Sagang et al.
Yuval R Zelnik et al.
Forest encroachment over savannahs has been recurrently reported in the tropics over the last few decades, especially in northern tropical Africa. However, process-based, spatially explicit modelling of the phenomenon is still trailing broa...
Strength asymmetry and replacement bias shape the evolution of cooperation in finite populations [0.03%]
力量不对称和替换偏差形塑有限种群中合作的演化
Haomin Wang,Zhenyu Shi,Sha Song
Haomin Wang
Heterogeneity is common in real populations, but many classic evolutionary game models assume identical individuals. Here, we study how two simple forms of heterogeneity affect the evolution of cooperation in a finite population. We constru...
The effect of historic climate change on the population dynamics of Ixodes ricinus [0.03%]
气候变迁对硬皮梭菌种群动态的影响
Dominic P Brass,Steven M White,Sarah J Burthe et al.
Dominic P Brass et al.
The distribution and intensity of tick-borne disease (TBD) transmission events across Europe are increasing in response to changes in climate, land use and host populations. Understanding how changing environmental factors drive seasonal ti...
Decentralized neural dynamics and sensory constraints shape brittle star locomotion [0.03%]
去中心化神经动力学和感觉约束塑造了brittle星的运动
Dries Marzougui,Dominique Adriaens,Francis Wyffels
Dries Marzougui
Brittle stars move with remarkable whole-body coordination despite lacking a central brain. With five identical arms radiating from a central disc, they predominantly adopt a bilaterally symmetrical rowing gait: one arm leads, two neighbour...
Non-invasive load measurement in the human tibia via spectral analysis of flexural waves [0.03%]
基于弯曲波频谱分析的人胫骨载荷无损测量
Ali Yawar,Daniel H Aslan,Daniel E Lieberman
Ali Yawar
Forces transmitted by bones are routinely studied in human biomechanics, but it is challenging to measure them non-invasively, especially outside of laboratory settings. We introduce a technique for non-invasive, in vivo measurement of tibi...