Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis [0.03%]
健康个体中的年龄依赖性免疫特征：原创研究、系统评价和meta分析
Syuan-Ting Chang,Yi-Fang Chuang,Ai-Hsien Li et al.
Syuan-Ting Chang et al.
Background: The circulatory peripheral immune system is the most convenient approach for determining an individual's immune status. Due to various reasons, while previous studies have addressed the critical impact of age,...
Biologically informed machine learning modeling of immune cells to reveal physiological and pathological aging process [0.03%]
基于免疫细胞的生物信息机器学习模型揭示生理及病理衰老过程
Cangang Zhang,Tao Ren,Xiaofan Zhao et al.
Cangang Zhang et al.
The immune system undergoes progressive functional remodeling from neonatal stages to old age. Therefore, understanding how aging shapes immune cell function is vital for precise treatment of patients at different life stages. Here, we cons...
Review of evidence linking exposure to environmental stressors and associated alterations in the dynamics of immunosenescence (ISC) with the global increase in multiple sclerosis (MS) [0.03%]
关于环境压力源暴露及其对免疫衰老动力学改变与全球多发性硬化症增加之间联系的证据回顾
Christopher Bolton
Christopher Bolton
Historical survey confirms that, over the latter part of the 20th century, autoimmune-based diseases, including multiple sclerosis (MS), have shown a worldwide increase in incidence and prevalence. Analytical population studies have establi...
Osama Ahmad,Muhammad Haris
Osama Ahmad
The World Health Organization recognizes frailty and multimorbidity as major global health issues and underscores the need for effective interventions. Recent advances have identified interleukin-11 (IL-11), a pro-inflammatory cytokine, as ...
Distinct immunomodulation elicited by young versus aged extracellular vesicles in bone marrow-derived macrophages [0.03%]
年轻和老化细胞外囊泡诱导的骨髓源性巨噬细胞免疫调节的区别
Dora Livkisa,Tsung-Lin Lee,Wei-Ting Yeh et al.
Dora Livkisa et al.
Background: Previous research has indicated that extracellular vesicles (EVs) potentially play significant roles in multiple ageing phenotypes. This study uses a factorial experimental design to explore the interactions b...
Association between serum IgM and all-cause mortality risk in Chinese centenarians: a prospective cohort study [0.03%]
中国百岁老人血清IgM与全因死亡率风险的前瞻性队列研究
Weiguang Zhang,Yuting Duan,Zhe Li et al.
Weiguang Zhang et al.
Background: We investigated the associations between IgM, IgG, IgA, and IgE levels and all-cause mortality risk in Chinese centenarians. Methods: ...
Health characteristics associated with persistence of SARS-CoV-2 antibody responses after repeated vaccinations in older persons over time: the Doetinchem cohort study [0.03%]
德廷赫姆队列研究中重复接种疫苗后老年人SARS-CoV-2抗体应答持久性的相关健康特征
Yunus Kuijpers,Joanna Kaczorowska,H Susan J Picavet et al.
Yunus Kuijpers et al.
Background: Older persons elicit heterogeneous antibody responses to vaccinations that generally are lower than those in younger, healthier individuals. As older age and certain comorbidities can influence these responses...
Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway [0.03%]
染料木素通过Bcl-2通路促进Tfh衰老细胞凋亡从而改善狼疮症状
Feng Xiong,Kai Shen,Di Long et al.
Feng Xiong et al.
Systemic lupus erythematosus (SLE) is an autoimmune disorder that commonly affects the skin, kidneys, joints, and various other systemic tissues, with its development intricately linked to the process of immunosenescence. Quercetin (QC), a ...
Inflammation scores based on C-reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis [0.03%]
入院诊断独立的基于C-反应蛋白和白蛋白的炎症评分可预测住院老年患者的死亡率
Mirko Di Rosa,Jacopo Sabbatinelli,Angelica Giuliani et al.
Mirko Di Rosa et al.
Systemic inflammation significantly increases the risk of short- and long-term mortality in geriatric hospitalized patients. To predict mortality in older patients with various age-related diseases and infections, including COVID-19, inflam...
Correction: Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway [0.03%]
校正：褪黑素通过JAK3-STAT5信号途径增加T-bet表达以增强衰老小鼠NK细胞功能
Caiying Liang,Rongrong Song,Jieyu Zhang et al.
Caiying Liang et al.
Published Erratum
Immunity & ageing : I & A. 2024 Oct 1;21(1):66. DOI:10.1186/s12979-024-00470-z 2024