IL-35 promotes synovial fibroblast senescence via activation of cGAS-STING-TBK1-IRF3 pathway in rheumatoid arthritis [0.03%]
IL-35通过激活cGAS-STING-TBK1-IRF3信号通路促进类风湿关节炎滑膜成纤维细胞衰老
Ziliang Yu,Zeyu Liu,Jianbo Fan et al.
Ziliang Yu et al.
Interleukin-35 (IL-35) exerts immunosuppressive effects in rheumatoid arthritis (RA), but its direct impact on synovial fibroblasts (SFs) remains unclear. This study aimed to redefine the role of IL-35 in RA by uncovering its therapeutic me...
Cellular senescence: the "hidden driver" in chronic inflammatory skin disorders [0.03%]
细胞衰老：慢性炎症性皮肤病的"隐匿驱动因素"
Huifang Liang,Junqin Li,Kaiming Zhang
Huifang Liang
Chronic inflammatory skin disorders are characterized by persistent skin inflammation, impaired barrier function, and frequent recurrence, all of which substantially reduce patients' quality of life. Traditional studies attribute the pathog...
Reduced NK cell frequency in older patients with evolving fractures is linked to a distinct inflammatory cytokine profile [0.03%]
老年骨折患者NK细胞频率降低与特定炎症细胞因子谱型有关
Julia P Moch,Jolane Kappes,Rodrigo Gutierrez Jauregui et al.
Julia P Moch et al.
Background: Proximal hip fractures represent a profound acute physiological stress in older adults and are often followed by infections, delayed recovery, and functional decline. These complications occur more frequently ...
Virtual memory CD8⁺ T cells in aging: heterogeneity, bystander protection, inflammatory potential, and inhibitory regulation [0.03%]
衰老过程中虚拟记忆CD8⁺ T细胞的异质性、旁观者保护作用、炎症潜能和抑制调节
Archit Kumar,Raymond Yung
Archit Kumar
Aging reshapes the CD8⁺ T cell compartment through contraction of the naïve pool and expansion of memory-phenotype populations, including the progressive accumulation of antigen-inexperienced virtual memory (VM) CD8⁺ T cells. VM CD8⁺ T ...
Patrick E Sewell,Christopher Jensen
Patrick E Sewell
Age-related thymic involution is a central feature of immunosenescence and intersects with multiple "hallmarks of aging", including genomic instability, telomere attrition, mitochondrial dysfunction, and chronic inflammation. The decline in...
Retraction Note: Gene and protein expression of CXCR4 in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations [0.03%]
撤回 notice:慢性鼻炎、咽炎或鼻窦炎成人及老年患者进行热矿泉吸入治疗的CXCR4基因和蛋白表达
Monica Neri,Luigi Sansone,Luisa Pietrasanta et al.
Monica Neri et al.
Longitudinal humoral and memory B-cell responses to repeated SARS-CoV-2 vaccination in long-term care facilities residents [0.03%]
长期护理机构居民反复接种新型冠状病毒肺炎疫苗后的纵向体液和记忆B细胞反应
Annapina Palmieri,Cecilia Damiano,Pasqualina Leone et al.
Annapina Palmieri et al.
Background: Long-term care facility (LTCF) residents represent one of the populations most vulnerable to SARS-CoV-2 infection and have experienced repeated vaccination and natural viral exposure since the beginning of the...
Advances in skin aging: integrating epigenetic, cellular, and immune mechanisms for targeted therapy [0.03%]
皮肤衰老的研究进展：表观遗传、细胞及免疫机制在靶向治疗中的整合
Jinxuan Su,Hongzhong Jin
Jinxuan Su
As the largest and most externally exposed organ, the skin is particularly vulnerable to aging, rendering skin aging a widespread clinical and aesthetic concern. Driven by both intrinsic and extrinsic factors, skin aging is characterized by...
An immune-associated mitochondrial DNA variant with sex differences reveals a putative novel microprotein called MASL [0.03%]
与性别差异相关的免疫相关线粒体DNA变异揭示了一种名为MASL的潜在新型微蛋白
Ana R Silverstein,Thalida E Arpawong,Eileen M Crimmins et al.
Ana R Silverstein et al.
The use of mitochondrial wide association studies (MiWAS) to link mitochondrial DNA variants (mtSNPs) to phenotypes of interest has uncovered important connections between mitochondrial genes and human health. The recent introduction of a r...
Immune risk phenotype and long-term mortality after community-acquired pneumonia in older adults: clinical and immune determinants [0.03%]
社区获得性肺炎老年患者的长期免疫风险表型及其死亡率：临床和免疫决定因素
Sandra Clotet-Vidal,Teresa Franco-Leyva,Encarna Saez Prieto et al.
Sandra Clotet-Vidal et al.
Background: Community-acquired pneumonia (CAP) has been associated with poor long-term outcomes in older adults. In most pre-pandemic studies, long-term mortality was assessed with a focus on comorbidity burden. Although ...