Chen Sun,Jiao Li,Heng Xu et al.
Chen Sun et al.
The global demographic shift towards an aging population has amplified the public health challenge posed by immunosenescence, a progressive remodeling of the immune system that compromises host defenses. This age-related decline is characte...
Adipose immune microenvironment: catalyst of age-related adipose tissue dysfunction [0.03%]
脂肪免疫微环境：年龄相关脂肪组织功能障碍的催化剂
Yuang Song,Haonan Xing,Yucheng Luo et al.
Yuang Song et al.
Aging has profound effects on whole-body homeostasis. With age, adipose tissue undergoes marked alterations in immune microenvironment and distribution as well as a loss of immune and metabolic capacities. Immune cells and adipokines consti...
Elderly female CTLs maintain their initial activation and cytotoxicity independent of IL-2 [0.03%]
老年人CTLs保持其初始活化和细胞毒性独立于IL-2
Chantal Hof,Adrian Angenendt,Sandra Janku et al.
Chantal Hof et al.
Background: Cytotoxic T lymphocytes (CTLs) are crucial for immune defence, with interleukin-2 (IL-2) playing a central role in their activation, proliferation, and effector functions. However, the impact of IL-2 on CTLs d...
Ascorbic acid attenuates immunosenescence and cognitive decline via MYH9-Mediated CD8⁺ T cell differentiation [0.03%]
维生素C通过MYH9介导的CD8⁺ T细胞分化来缓解免疫衰老和认知衰退
Taotao Mi,Shanshan Yang,Nan Wang et al.
Taotao Mi et al.
Background: Immune function decline (immunosenescence) accelerates systemic aging and adversely impacts cognitive function. Antioxidants may mitigate these effects; however, the role of ascorbic acid (AA), a key anti...
Vitamin D and the aging skin: insights into oxidative stress, inflammation, and barrier function [0.03%]
维生素D与老化皮肤：氧化压力、炎症及屏障功能的新认识
Hanlin Gao,Tianyi Xie,Yue Zhang et al.
Hanlin Gao et al.
Skin aging is a multifactorial biological process driven by the cumulative effects of oxidative stress, chronic low-grade inflammation, and progressive deterioration of barrier function. Among its pivotal regulatory nodes, the Vitamin D-Vit...
Pauline Saint-Charles,Arnaud M Didierlaurent,Victor Appay
Pauline Saint-Charles
People living with HIV-1 (PLWH) are a population at higher risk for communicable disease and therefore a target group for vaccination. Owing to the success of anti-retroviral therapy, PLWH live longer, but face new challenges related to age...
Differential immune profiles in elderly patients with non-severe versus severe SARS-CoV-2 omicron variant infection: dysregulation of antibody responses and B-cell subsets [0.03%]
非重症与重症老年患者感染新型冠状病毒 Omicron 变异株的免疫特征差异：抗体反应和B细胞亚群失调
Xue Li,Yuanyuan Li,Shiyang Liu et al.
Xue Li et al.
Background: Elderly individuals represent a population at disproportionate risk for severe outcomes following SARS-CoV-2 infection. The humoral immune response critically controls viral replication and disease progression...
Immunosenescence and organoids: pathophysiology and therapeutic opportunities [0.03%]
免疫衰老与类器官：病理生理及治疗机会
Amirhossein Kamroo,Mahsa Hosseini Kakroudi,Amirreza Jabbaripour Sarmadian et al.
Amirhossein Kamroo et al.
Immunosenescence is the gradual deterioration in the functionality of the immune system that has various clinical manifestations, such as a weakened response to vaccination, higher susceptibility to viral/bacterial/fungal infection, and hig...
Salivary gland cell senescence in Sjögren's syndrome: current research and novel therapeutic directions [0.03%]
原发性舍格伦综合征的唾液腺细胞衰老：当前研究和新的治疗思路
Xiaoyu Tang,Jingjin Hu,Xinying Fan et al.
Xiaoyu Tang et al.
Sjögren's syndrome (SS) is an autoimmune disease primarily affecting exocrine glands, characterized by dry mouth and eyes, with an unclear pathogenesis. Recent studies suggest that salivary gland (SG) cell senescence is critical in SS path...
Re-evaluating CD57 as a marker of T cell senescence: implications for immune ageing and differentiation [0.03%]
CD57作为T细胞衰老标志物的再评价：对免疫老化和分化的启示
Gaëlle Autaa,Daniil Korenkov,Josine van Beek et al.
Gaëlle Autaa et al.
Ageing is accompanied by a decline in immune function, associated with susceptibility to infections and malignancies, and reduced vaccine efficacy. These immunological changes, affect multiple components of the immune system, particularly T...