The role of autoantibodies in bridging obesity, aging, and immunosenescence [0.03%]
自身抗体在肥胖、衰老和免疫老化之间的桥梁作用
Taylor R Valentino,Nan Chen,Priya Makhijani et al.
Taylor R Valentino et al.
Antibodies are essential to immune homeostasis due to their roles in neutralizing pathogenic agents. However, failures in central and peripheral checkpoints that eliminate autoreactive B cells can undermine self-tolerance and generate autoa...
Detection of HHV-5 HHV-6a HHV-6b and HHV-7 in the urine: potential use as a non-invasive diagnostic tool for immune profiling [0.03%]
HHV-5、HHV-6A、HHV-6B和HHV-7尿液检测：作为非侵入性诊断工具用于免疫分型的潜在应用
Shelia Govind,Pierre Olivier Lang,Alexander Bürkle et al.
Shelia Govind et al.
Decline in immune function with age has been studied extensively, but approaches to immune restoration have been hampered by the lack of simple methods of identifying individuals whose immune system is in decline. Our approach has been to i...
Blood based immune biomarkers associated with clinical frailty scale in older patients with melanoma receiving checkpoint inhibitor immunotherapy [0.03%]
血液免疫生物标志物与临床脆弱度评分在老年黑色素瘤患者中的关联性研究——免疫治疗角度
Estelle Tran Van Hoi,Saskia J Santegoets,Simon P Mooijaart et al.
Estelle Tran Van Hoi et al.
Introduction: Immunotherapy with checkpoint inhibition (ICI) is increasingly prescribed to older patients with cancer. High age, especially in combination with frailty, has been associated to immune senescence, which is t...
Elocalcitol mitigates high-fat diet-induced microglial senescence via miR-146a modulation [0.03%]
埃洛可替醇通过调节miR-146a缓解高脂饮食诱导的小胶质细胞衰老
Keerthana Chithanathan,Monika Jürgenson,Katrina Ducena et al.
Keerthana Chithanathan et al.
Background: MicroRNAs (miRNAs) play crucial roles in regulating inflammation and cellular senescence. Among them, miR-146a has emerged as a key modulator of inflammation, but its role in obesity-induced senescence remains...
Age-related STING suppression in macrophages contributes to increased viral load during influenza a virus infection [0.03%]
STING在巨噬细胞中的年龄相关抑制作用导致A型流感病毒感染后的病毒载量增加
Thurid Lauf,Antje Häder,Franziska Hornung et al.
Thurid Lauf et al.
Ageing is a major risk factor that contributes to increased mortality and morbidity rates during influenza A virus (IAV) infections. Macrophages are crucial players in the defense against viral infections and display impaired function durin...
Peripheral CD4+ T cell phenotype and brain microglial activation associated with cognitive heterogeneity in aged rats [0.03%]
老龄大鼠外周CD4+T细胞表型与大脑小胶质细胞活化相关并影响认知差异性
Lian Yu,Miao-Miao Liu,Mei-Qi Guan et al.
Lian Yu et al.
Cognitive decline is a critical hallmark of brain aging. Although aging is a natural process, there is significant heterogeneity in cognition levels among individuals; however, the underlying mechanisms remain uncertain. In our study, we cl...
Correction: Inflammation scores based on C‑reactive protein and albumin predict mortality in hospitalized older patients independent of the admission diagnosis [0.03%]
校正：C-反应蛋白和白蛋白为基础的炎症评分可独立于入院诊断预测住院老年患者的死亡率
Mirko Di Rosa,Jacopo Sabbatinelli,Angelica Giuliani et al.
Mirko Di Rosa et al.
Published Erratum
Immunity & ageing : I & A. 2024 Nov 13;21(1):79. DOI:10.1186/s12979-024-00483-8 2024
The association of multidimensional frailty with metabolic syndrome and low-grade inflammation in community-dwelling older adults in the Netherlands: a Lifelines cohort study [0.03%]
荷兰Lifelines队列研究中多维衰弱与代谢综合征及低度炎症在社区居住老年人中的关联性研究
Martine J Sealy,Iris M Y van Vliet,Harriët Jager-Wittenaar et al.
Martine J Sealy et al.
Background: Preventing metabolic syndrome (MetS) and frailty in older adults is crucial for healthy aging. The association between MetS and physical frailty is well-documented, with low-grade inflammation as potential exp...
p16Ink4a-induced senescence in cultured mast cells as a model for ageing reveals significant morphological and functional changes [0.03%]
P16INK4A诱导的培养肥大细胞衰老作为衰老模型显示出显著的形态和功能变化
Elisabeth Kleeblatt,Pia Lazki-Hagenbach,Ellon Nabet et al.
Elisabeth Kleeblatt et al.
Background: Mast cells (MCs) are tissue resident cells of the immune system, mainly known for their role in allergy. However, mounting evidence indicates their involvement in the pathology of age-related diseases, such as...
Crosstalk between adipogenesis and aging: role of polyphenols in combating adipogenic-associated aging [0.03%]
脂肪细胞生成与衰老之间的相互作用：多酚类化合物在对抗脂肪生成相关衰老中的作用
Khalid Al-Regaiey
Khalid Al-Regaiey
In the last forty years, the number of people over 60 years of age has increased significantly owing to better nutrition and lower rates of infectious diseases in developing countries. Aging significantly impacts adipose tissue, which plays...