The state of the art in anti-aging: plant-based phytochemicals for skin care [0.03%]
抗衰老的植物化学成分护肤研究进展
Merve Tomas,Deniz Günal-Köroğlu,Senem Kamiloglu et al.
Merve Tomas et al.
Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin's structural integrity. Carotenoids, vitamins, essential fatty acids, and phenolic compounds work by acting as an...
Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis [0.03%]
线粒体形态和功能障碍加重老年人溃疡性结肠炎炎症反应
Mengmeng Zhang,Hong Lv,Xiaoyin Bai et al.
Mengmeng Zhang et al.
Background: The characteristics of ulcerative colitis (UC) in the elderly are quite different from the young population. Mitochondrial injury is a key mechanism regulating both aging and inflammation. This study aims to r...
Limited restoration of T cell subset distribution and immune function in older people living with HIV-1 receiving HAART [0.03%]
高效抗逆转录病毒治疗部分恢复了HIV感染老年人的T细胞亚群分布和免疫功能
Na Li,Hong-Yi Zheng,Wei Li et al.
Na Li et al.
Background: Older people living with HIV-1 (PLWH) experience a dual burden from the combined effects of aging and HIV-1 infection, resulting in significant immune dysfunction. Despite receiving HAART, immune reconstitutio...
Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats [0.03%]
肥胖相关记忆障碍和神经炎症先于年长大鼠的全身紊乱出现
Michael J Butler,Stephanie M Muscat,Maria Elisa Caetano-Silva et al.
Michael J Butler et al.
Background: Obesity and metabolic syndrome are major public health concerns linked to cognitive decline with aging. Prior work from our lab has demonstrated that short-term high fat diet (HFD) rapidly impairs memory funct...
High SARS-CoV-2 antibody levels after three consecutive BNT162b2 booster vaccine doses in nursing home residents [0.03%]
养老机构居民连续接种三剂BNT162b2疫苗后的高新冠病毒抗体水平
Marloes I Hofstee,Joanna Kaczorowska,Abigail Postema et al.
Marloes I Hofstee et al.
Background: As older age and having certain comorbidities can influence humoral responses to vaccination, we studied antibody responses after the COVID-19 booster campaigns in nursing home (NH) residents. ...
scRNA + BCR-seq identifies proportions and characteristics of dual BCR B cells in the peritoneal cavity of mice and peripheral blood of healthy human donors across different ages [0.03%]
单细胞RNA和BCR测序鉴定小鼠腹膜腔和健康人类外周血中双重BCR的B细胞的比例及特性
Huifang Wang,Jun Li,Yuanyuan Xu et al.
Huifang Wang et al.
The increased incidence of inflammatory diseases, infectious diseases, autoimmune disorders, and tumors in elderly individuals is closely associated with several well-established features of immunosenescence, including reduced B cell genesi...
Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity [0.03%]
微量营养素作为调节老化人群免疫的物质：集中针对炎症和自身免疫反应
Bhavani Sowndharya Balamurugan,Mathan Muthu Chinnakannu Marimuthu,Vickram Agaram Sundaram et al.
Bhavani Sowndharya Balamurugan et al.
Immunosenescence, the slow degradation of immune function over time that is a hallmark and driver of aging, makes older people much more likely to be killed by common infections (such as flu) than young adults, but it also contributes great...
CD57+ EMRA CD8+ T cells in cancer patients over 70: associations with prior chemotherapy and response to anti-PD-1/PD-L1 therapy [0.03%]
老年癌症患者中CD57+EMRA CD8+T细胞与既往化疗史及抗PD-1/PD-L1治疗应答的关系
Cécile Gonnin,Michelle Leemans,Florence Canoui-Poitrine et al.
Cécile Gonnin et al.
Background: Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investi...
Differential associations of anti-cytomegalovirus antibodies and soluble CD14 levels with immunosenescence in people living with HIV on long term antiretroviral therapy [0.03%]
长期接受抗逆转录病毒治疗的HIV感染者的免疫衰老与抗巨细胞病毒抗体及可溶性CD14水平的关系
Ashwini Vinod Shete,Pallavi Shidhaye,Amrita Rao et al.
Ashwini Vinod Shete et al.
Background: People living with HIV (PLHIV) demonstrate accelerated aging and immunosenescence in spite of immune-restoration following long-term antiretroviral treatment (ART). Low level inflammation leading to inflammagi...
Characterisation of specific responses to three models of viral antigens in immunocompetent older adults [0.03%]
免疫功能正常的老年人对三种病毒抗原模型的特异性反应特征分析
Beatriz Rioseras,Eva Bueno-García,Alejandra García-Torre et al.
Beatriz Rioseras et al.
Background: Memory responses to the antigens that an individual encounters throughout life may vary with the intensity and duration of antigen contacts or even with changes in immune status over time. This work aims to ch...