Chronic IL-21 drives neuroinflammation and promotes lipid accumulation in microglia [0.03%]
慢性IL-21驱动神经炎症并促进小胶质细胞脂质积累
Hugo Oyamada,Yinzhi Ying,Sudhanshu Agrawal et al.
Hugo Oyamada et al.
Neuroinflammation is a key contributor to the onset and progression of neurodegenerative diseases, driven by factors such as viral infections, autoimmune disorders, and peripheral inflammation. However, the mechanisms linking peripheral inf...
Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination [0.03%]
年长的造血干细胞保持重塑年轻生发细胞系统的能力以响应基于蛋白质的疫苗接种
Paul Kunath,Dominik Pflumm,Bettina Moehrle et al.
Paul Kunath et al.
Background: Ageing-associated remodeling of the murine B cell system is accompanied with a reduction of CD19+ B cells such as follicular B cells (FOB) and an accumulation of age-associated B cells (ABC) or activated B cel...
Enhancing flu vaccine responses in older adults: preliminary insights from the ISOLDA study on immunosenescence and antioxidant and anti-inflammatory approaches [0.03%]
增强老年人的流感疫苗反应：ISOLDA研究关于免疫衰老和抗氧化及抗炎方法的初步见解
Anna Aiello,Anna Calabrò,Mattia Emanuela Ligotti et al.
Anna Aiello et al.
Aging is frequently characterized by an inadequate primary vaccine response, likely due to immunosenescence and inflamm-aging, a low-level, chronic inflammatory state. Both aspects increase the susceptibility of older adults to viral and ba...
Compositional analysis of lymphocytes and their relationship with health outcomes: findings from the health and retirement study [0.03%]
淋巴细胞的组成分析及其与健康结果的关系：来自健康和退休研究的研究发现
Lantian Xu,Chihua Li,Allison E Aiello et al.
Lantian Xu et al.
Background: Immunosenescence, the gradual deterioration of the immune system, is critical for aging-related diseases. However, the lack of detailed population-level immune data has limited our understanding, underscoring ...
Delayed viral clearance and altered inflammatory responses affect severity of SARS-CoV-2 infection in aged mice [0.03%]
衰老小鼠中病毒清除延迟和炎症反应改变会影响新冠病毒感染的严重程度
Émile Lacasse,Isabelle Dubuc,Leslie Gudimard et al.
Émile Lacasse et al.
Epidemiological investigations consistently demonstrate an overrepresentation of the elderly in COVID-19 hospitalizations and fatalities, making the advanced age as a major predictor of disease severity. Despite this, a comprehensive unders...
CD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults [0.03%]
CD31 + 初次T细胞与老年人的免疫衰老和对多种疫苗的反应有关
Alper Cevirgel,Martijn Vos,Elske Bijvank et al.
Alper Cevirgel et al.
Background: The T cell compartment undergoes significant age-related changes, contributing to the decline of the adaptive immune system and increasing the risk of suboptimal antibody responses to vaccines in older adults....
Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging [0.03%]
分泌型IgM缺乏通过增强与年龄相关的神经退行性变来改变视网膜环境
Sarah E Webster,Sydney M Les,Nico Deleon et al.
Sarah E Webster et al.
Background: Maintenance of the retina, part of the central nervous system, and other structures in the eye is critical for vision preservation. Aging increases the prevalence of vision impairment, including glaucoma, macu...
Exploring the link between fat-soluble vitamins and aging-associated immune system status: a literature review [0.03%]
脂溶性维生素与衰老相关免疫系统状态的关联探索：文献回顾
Hendrik Schmieder,Christian Leischner,Alban Piotrowsky et al.
Hendrik Schmieder et al.
The importance of vitamin D for a well-functioning immune system is becoming increasingly evident. Nevertheless, the other fat-soluble vitamins A, E and K also seem to play a central role regarding the adequate function of immune cells and ...
Effect and mechanism of miRNA-144-5p-regulated autophagy in older adults with Sarcopenia [0.03%]
miRNA-144-5p调控的自噬在肌少症老年人中的作用及机制研究
Mengdie Hu,Ying Zhang,Hong Ding et al.
Mengdie Hu et al.
Background: Advanced aging invariably triggers an overabundance of apoptosis, stemming from diminished autophagy or a disarray in cellular autophagic processes. This, in turn, leads to an accelerated breakdown of muscle p...
The relationship between biological aging and psoriasis: evidence from three observational studies [0.03%]
来自三项观察性研究的证据：生物老化与银屑病之间的关系
Zheng Lin,Hong-Fei Wang,Lu-Yan Yu et al.
Zheng Lin et al.
Background: The relationship between psoriasis and aging remains unclear. Biological age is considered as a tool for strong association with aging, but there is a lack of reports on the relationship between biological age...