The aging immune system and all-cause mortality in older americans: differences across sex and race/ethnicity [0.03%]
美国老年人的免疫系统老化和全因死亡率：性别与种族/民族差异
Kate A Duchowny,Yuan S Zhang,Rebecca C Stebbins et al.
Kate A Duchowny et al.
Background: As individuals age, the immune system undergoes complex changes, including an increase in the number of CD8 T cells relative to CD4 T cells, a decline in naïve cell production (including T and B cells), and a...
Frequency of synaptic antigen-specific CD4+ T cells in dementia is age-dependent but not correlated with cognitive impairment [0.03%]
老年痴呆患者脑中突触相关CD4+T细胞频率与年龄相关但不伴随认知功能下降
Julius Hoffmann,Marie-Luise Machule,Jakob Kreye et al.
Julius Hoffmann et al.
Neurodegenerative dementias including Alzheimer disease severely impair cognitive and social abilities and are a major cause of mortality with no causal treatment yet. Autoimmune mechanisms have been increasingly considered to contribute to...
Associations of serum total light chain kappa and lambda levels with all-cause mortality in Chinese centenarians [0.03%]
中国百岁老人中全因死亡率与血清总轻链κ和λ水平的关系
Yuting Duan,Zhe Li,Weiguang Zhang et al.
Yuting Duan et al.
The purpose of this study was to determine the relationship between the serum levels of kappa (κ) and lambda (λ) total light chain (TLC), the κ/λ ratio, and the combined serum TLCκ and TLCλ (ΣTLC) levels in Chinese centenarians and a...
Eva Dervas,Udo Hetzel,Anja Kipar
Eva Dervas
Aging is a complex and multifaceted biological process that results in the gradual decline of physiological functions over time. It is associated with reduced performance across multiple systems, affecting metabolic, reproductive, musculosk...
Diverging effects of tumor necrosis factor inhibitors and conventional synthetic disease-modifying antirheumatic drugs on immunosenescence and inflammageing in rheumatoid arthritis: a cross-sectional analysis [0.03%]
肿瘤坏死因子抑制剂和常规合成疾病修饰抗风湿药物对类风湿关节炎免疫衰老和炎症老化的影响：横断面分析
Tobias Schwarz,Giovanni Almanzar,Sebastian Völkl et al.
Tobias Schwarz et al.
Background: Immunosenescence is characterized by a decline in naive T cells, a reduced T cell receptor repertoire, and the accumulation of terminally-differentiated and unspecifically-activated proinflammatory cells, a pr...
Zinc deficiency as possible link between immunosenescence and age-related diseases [0.03%]
锌缺乏可能是免疫衰老和年龄相关疾病之间的可能联系
Michael Tobias Schulz,Lothar Rink
Michael Tobias Schulz
As global life expectancy increases, research reveals a critical challenge in aging: the progressive deterioration of immune function, termed immunosenescence. This age-related immune decline is characterized by a complex dysregulation of i...
Gut-vitamin D interplay: key to mitigating immunosenescence and promoting healthy ageing [0.03%]
肠道-维生素D互作：缓解免疫衰老和促进健康老龄的关键因素
Hammad Ullah
Hammad Ullah
Background: Immunosenescence is the loss and change of immunological organs, as well as innate and adaptive immune dysfunction with ageing, which can lead to increased sensitivity to infections, age-related diseases, and ...
Immunological enhancement of micro-nanoparticle formulated with risedronate and zinc as vaccine adjuvant in aged mice [0.03%]
硫酸利塞膦酸锌微/纳米颗粒疫苗佐剂的免疫增强作用研究
Yue Liu,Man Yang,Meifeng Nie et al.
Yue Liu et al.
Background: Elderly individuals face heightened susceptibility to infectious diseases and diminished vaccine responses. Vaccine adjuvants offer a solution. Despite aluminum adjuvant's long history, its limitations in indu...
The immunological age prediction of monocytes indicates that gestational diabetes mellitus accelerates the aging of monocytes in offspring [0.03%]
单核细胞免疫学衰老时钟表明妊娠期糖尿病加速子代单核细胞衰老
Yan Zhang,Rui Guo,Min Yin et al.
Yan Zhang et al.
Background: Recent studies have suggested that gestational diabetes mellitus (GDM) can accelerate cellular aging in multiple cell types in offspring, but its impact on immune senescence remains uncertain. Our prior study ...
Pentraxin-3 and C-reactive protein plasma levels predict survival in older adults with or without metabolic syndrome - results of the PolSenior2 substudy [0.03%]
pentraxin-3和C反应蛋白水平可预测代谢综合征老年人的生存率-PolSenior2子研究结果
Aleksander J Owczarek,Anna Ochman,Anna Chudek et al.
Aleksander J Owczarek et al.
Objective: There are no published data on the associations between plasma concentration of pentraxin-3 (PTX-3) - a marker of vascular inflammation and mortality in older subjects with or without metabolic syndrome (MS). T...