Anteneh Mehari Tizazu,Eyerusalem Amossa Tessema,Olivier Nf Cexus
Anteneh Mehari Tizazu
Known as immunosenescence, the major dysregulation of the immune system with age is associated with poor vaccination efficacy, and increased susceptibility to infections, age-related pathologies, and neoplasms, with incidences exacerbated w...
Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport [0.03%]
代谢健康人群的极端差异与血浆炎症和胆固醇运输标志物相关性研究
Daniele Bizzarri,Erik B van den Akker,Marcel J T Reinders et al.
Daniele Bizzarri et al.
The MetaboHealth score is an indicator of physiological frailty in middle aged and older individuals. The aim of the current study was to explore which molecular pathways co-vary with the MetaboHealth score. Using a Luminex cytokine assay a...
Systemic inflammation as a central player in the initiation and development of Alzheimer's disease [0.03%]
系统炎症在阿尔茨海默病的发病和发展中的核心作用
Irem Bayraktaroglu,Natalia Ortí-Casañ,Debby Van Dam et al.
Irem Bayraktaroglu et al.
Alzheimer's disease (AD) is an age-related neurodegenerative disorder and the most common cause of dementia. While the amyloid cascade hypothesis has long dominated AD research, emerging evidence suggests that neuroinflammation may play a m...
Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling [0.03%]
启福饮通过CCR3信号抑制微胶质细胞衰老从而对抗CCL11诱导的认知障碍
Sheng Tian,Tianyuan Ye,Chao Tian et al.
Sheng Tian et al.
Background: The chemokine CCL11 is negatively correlated with cognitive function and is able to cause dysfunctions of synaptic plasticity. This research investigate whether CCL11 induce microglia senescence to damage syna...
Natália de Souza Xavier Costa,Jôse Mara de Brito,Carla Froio et al.
Natália de Souza Xavier Costa et al.
Elderly individuals were disproportionally affected during the COVID-19 pandemic, and more than 80% of the global COVID-19-related deaths between 2020 and 2021 occurred among people aged 60 years or older. Several cellular modifications in ...
p38 mitogen-activated protein kinase drives senescence in CD4+ T lymphocytes and increases their pathological potential [0.03%]
CD4⁺T淋巴细胞中p38丝裂原活化蛋白激酶驱动的衰老及其病理潜能增强机制研究
Luis González-Osuna,Sandra Yasuyo Fukada,María Paz Hernández-Cáceres et al.
Luis González-Osuna et al.
Background: In several diseases, senescent T lymphocytes increase in number and release a senescence-associated secretory phenotype (SASP) with inflammatory and osteoclastogenic potential, favoring inflammation and bone l...
Aging modulates the immunosuppressive, polarizing and metabolic functions of blood-derived myeloid-derived suppressor cells (MDSCs) [0.03%]
衰老调节血液来源的髓系衍生抑制细胞的功能
Emma Keltsch,Jennifer Greiner,Lena Wahl et al.
Emma Keltsch et al.
Background: Immunosenescence describes the gradual remodeling of immune responses, leading to disturbed immune homeostasis and increased susceptibility of older adults for infections, neoplasia and autoimmunity. Decline i...
Different CMV-specific effector T cell subtypes are associated with age, CMV serostatus, and increased systolic blood pressure [0.03%]
不同CMV特异性效应T细胞亚型与年龄、CMV血清状态和收缩压升高相关
Lennart M Roesner,Berislav Bošnjak,Stephan Traidl et al.
Lennart M Roesner et al.
Background: Cytomegalovirus (CMV) infection is one of the most common infections in humans, and CMV antigens are the major drivers of repetitive T-cell stimulation as a part of a well-adapted immune response in immunocomp...
Differential effects of young and old hematopoietic stem cell niches on bone marrow-derived dendritic cells [0.03%]
年轻和年老造血干细胞生态位对骨髓来源的树突状细胞的影响不同
Patrik Milić,Mojca Justin Kjuder,Katerina Jazbec Gradišar et al.
Patrik Milić et al.
Background: Aging is linked to various dysfunctions of the immune system, including the decline of its primary developmental source: the hematopoietic stem cell (HSC) niche. This decline leads to chronic inflammation, inc...
Targeting aging pathways with natural compounds: a review of curcumin, epigallocatechin gallate, thymoquinone, and resveratrol [0.03%]
靶向衰老通路的天然化合物：姜黄素、表没食子儿茶素没食子酸酯、伏马菌素和白藜芦醇综述
Mohamed Ahmed
Mohamed Ahmed
Aging is a multifactorial biological process driven by oxidative stress, chronic inflammation, genomic instability, and mitochondrial dysfunction. Recent research underscores the potential of naturally derived compounds to modulate these ag...