Re-evaluating CD57 as a marker of T cell senescence: implications for immune ageing and differentiation [0.03%]
CD57作为T细胞衰老标志物的再评价：对免疫老化和分化的启示
Gaëlle Autaa,Daniil Korenkov,Josine van Beek et al.
Gaëlle Autaa et al.
Ageing is accompanied by a decline in immune function, associated with susceptibility to infections and malignancies, and reduced vaccine efficacy. These immunological changes, affect multiple components of the immune system, particularly T...
The influence of structured physical activity on vaccination response from adults to older individuals: a systematic review on the Immunoinflammatory crosstalk of COVID-19 [0.03%]
结构化体育活动对成人至老年人群接种疫苗反应的影响：一项关于新冠肺炎免疫炎症交叉联系的系统性回顾研究
Bruna Maria Palotino-Ferreira,Saulo Vasconcelos Rocha,Albená Nunes-Silva et al.
Bruna Maria Palotino-Ferreira et al.
Background: Amidst the ongoing COVID-19 pandemic, understanding factors that influence vaccine efficacy is crucial, particularly in older adults. Regular physical exercise and/or structured physical activity (SPA) has eme...
Immune-mediated interactions between sarcopenia and atherosclerosis in aging [0.03%]
衰老过程中免疫介导的肌少症和动脉粥样硬化相互作用机制研究
Mei Yu,Rujia Zhao,Lichao Ge et al.
Mei Yu et al.
Sarcopenia and atherosclerosis are prevalent age-related conditions increasingly recognized as interconnected through shared immune-mediated pathways. This review elucidates how "inflammaging" driven by dysregulated immune responses. Key ag...
Age-stratified circulating immune signatures reveal non-invasive biomarkers for colorectal cancer detection [0.03%]
基于年龄分层的循环免疫特征发现结直肠癌非侵入性标志物
Julia Del Prado-Montero,Jenny Guevara-Martínez,Ramón Cantero-Cid et al.
Julia Del Prado-Montero et al.
Ageing is a well-recognised factor influencing immune competence; however, elderly individuals remain underrepresented in clinical trials, resulting in gaps in our understanding of their immune responses to disease. To address this gap, we ...
Elicitation of protective immune responses against influenza a viruses in elderly ferrets by adjuvanted recombinant universal influenza hemagglutinin vaccines [0.03%]
带佐剂的重组通用流感血凝素疫苗对老年雪貂流感病毒免疫反应的影响
Xiaojian Zhang,Hua Shi,Ted M Ross
Xiaojian Zhang
Influenza viruses remain a significant threat to both animals and public health. Each season influenza virus infection causes significant morbidity and mortality, especially in the elderly population. Annual vaccination boosts antibody tite...
Characteristics of peripheral blood lymphocyte subsets in elderly patients with psoriasis [0.03%]
老年人银屑病外周血淋巴细胞亚群特征分析
RuiZhen Liu,Juan Zhao,Qian Gao et al.
RuiZhen Liu et al.
Objective: To investigate the distribution characteristics of peripheral blood lymphocyte subsets in elderly psoriasis patients and analyze the interactions between immunosenescence and psoriasis and their impact on immun...
Algorithms for appropriate patient stratification in the face of a new SARS-CoV-2 pandemic [0.03%]
应对新的新型冠状病毒肺炎疫情的适当患者分层算法
Paula Álvarez,Ana Navas,Manuel Martí-Antonio et al.
Paula Álvarez et al.
Background: Although the SARS-Cov-2 pandemic has passed, the virus continues to cause infection and death. Immunological response is crucial to overcome the disease. Elucidating the prognostic value of measurable immunolo...
Phenotypes, mechanisms, and therapeutic strategies of natural killer cell immunosenescence [0.03%]
自然杀伤细胞免疫衰老的表型、机制及治疗策略
Zixuan Guo,Fengtian Wu,Yao Chen et al.
Zixuan Guo et al.
Background: Natural killer (NK) cells serve as pivotal effector cells within the innate immune system, playing an indispensable role against infections and tumors. Individuals with diminished NK cell activity or NK cell d...
Ashley Johnson,Troy Rought,Jacob Aronov et al.
Ashley Johnson et al.
Cellular senescence is a fundamental biological process characterized by stable cell cycle arrest, genomic instability, and the acquisition of a proinflammatory secretory phenotype. While senescence is traditionally associated with aging, g...
Early-life thymectomy results in visceral adipose tissue inflammation and glucose intolerance [0.03%]
早年切除胸腺可致内脏脂肪组织炎症和葡萄糖不耐受
David J Buckley,Sogol Zahedi,Prema Velusamy et al.
David J Buckley et al.
We have previously demonstrated that proinflammatory T cells in adipose tissue and the liver play a mechanistic role in glucose intolerance in old mice. Further, we and others have demonstrated that early life thymectomy results in a T cell...