Monocyte-driven inflamm-aging reduces intestinal barrier function in females [0.03%]
单核细胞驱动的炎性衰老降低女性肠道屏障功能
Candice Quin,Jessica A Breznik,Allison E Kennedy et al.
Candice Quin et al.
Background: The intestinal barrier encompasses physical and immunological components that act to compartmentalize luminal contents, such as bacteria and endotoxins, from the host. It has been proposed that an age-related ...
Association of adipose tissue inflammation and physical fitness in older adults [0.03%]
老年人脂肪组织炎症与体能的关联性研究
Anna Tylutka,Barbara Morawin,Natalia Torz et al.
Anna Tylutka et al.
An active lifestyle is of key importance for reduction of obesity and inflammation, as well as circulating levels of adipokines. Therefore, the aim of our study was to assess the relationship of physical fitness with chronic inflammatory st...
Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults [0.03%]
重复接种新冠mRNA疫苗导致老年人IgG4类别转换和S1特异性抗体介导的NK细胞活化降低
Anne T Gelderloos,Marije K Verheul,Irene Middelhof et al.
Anne T Gelderloos et al.
Background: Previous research has shown that repeated COVID-19 mRNA vaccination leads to a marked increase of SARS-CoV-2 spike-specific serum antibodies of the IgG4 subclass, indicating far-reaching immunoglobulin class s...
Ageing results in an exacerbated inflammatory response to LPS by resident lung cells [0.03%]
衰老会加剧肺部固有细胞对LPS的炎症反应
Celia Diaz-Nicieza,Laura Sahyoun,Christina Michalaki et al.
Celia Diaz-Nicieza et al.
Background: Ageing is associated with an increased risk of lung infection and chronic inflammatory lung disease. Innate immune responses are the first line of defence in the respiratory tract, however, age-related changes...
Warmer environmental temperature accelerates aging in mosquitoes, decreasing longevity and worsening infection outcomes [0.03%]
环境温度升高加速蚊虫衰老，缩短寿命并加重感染后果
Jordyn S Barr,Lindsay E Martin,Ann T Tate et al.
Jordyn S Barr et al.
Background: Most insects are poikilotherms and ectotherms, so their body temperature is predicated by environmental temperature. With climate change, insect body temperature is rising, which affects how insects develop, s...
Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses [0.03%]
特征年龄相关炎症小体激活揭示了转录和翻译后炎症反应的组织特异性差异
Sarah Talley,Tyler Nguyen,Lily Van Ye et al.
Sarah Talley et al.
Aging is associated with systemic chronic, low-grade inflammation, termed 'inflammaging'. This pattern of inflammation is multifactorial and is driven by numerous inflammatory pathways, including the inflammasome. However, most studies to d...
Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway [0.03%]
褪黑素通过JAK3-STAT5信号通路增加T-bet表达来增强衰老小鼠NK细胞的功能
Caiying Liang,Rongrong Song,Jieyu Zhang et al.
Caiying Liang et al.
Natural killer (NK) cells are crucial innate immune cells that provide defense against viruses and tumors. However, aging is associated with alterations in NK cell composition and compromised cell functions. Melatonin, known for its anti-tu...
Correction: Heat‑killed probiotic Levilactobacillus brevis MKAK9 and its exopolysaccharide promote longevity by modulating aging hallmarks and enhancing immune responses in Caenorhabditis elegans [0.03%]
纠正：热灭活益生菌Levilactobacillus brevis MKAK9及其胞外多糖通过调节衰老标志物和增强免疫反应促进Caenorhabditis elegans长寿
Arun Kumar,Manti Kumar Saha,Vipin Kumar et al.
Arun Kumar et al.
Published Erratum
Immunity & ageing : I & A. 2024 Aug 31;21(1):58. DOI:10.1186/s12979-024-00464-x 2024
Role for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice [0.03%]
BLT1在调节老年小鼠脂肪组织免疫细胞炎症中的作用
Wei-Ching Shih,In Hwa Jang,Victor Kruglov et al.
Wei-Ching Shih et al.
Background: Aging is a complex biological process characterized by obesity and immunosenescence throughout the organism. Immunosenescence involves a decline in immune function and the increase in chronic-low grade inflamm...
Mouse brain contains age-dependent extraparenchymal granular structures and astrocytes, both reactive to natural IgM antibodies, linked to the fissura magna [0.03%]
小鼠大脑含有年龄依赖性的室管膜颗粒状结构和星形胶质细胞，可被天然IgM抗体激活，并与大脑镰刀相关
Clara Romera,Marta Riba,Raquel Alsina et al.
Clara Romera et al.
Background: Mouse brains can contain specific polyglucosan aggregates known as Periodic Acid-Schiff (PAS)-granules. Generated in astrocytes, these granules increase with age and exhibit neo-epitopes of carbohydrate nature...