Defective HIV-1 genomes and their potential impact on HIV pathogenesis [0.03%]
缺陷型HIV-1基因组及其对艾滋病发病机制的潜在影响
Jeffrey Kuniholm,Carolyn Coote,Andrew J Henderson
Jeffrey Kuniholm
Defective HIV-1 proviruses represent a population of viral genomes that are selected for by immune pressures, and clonally expanded to dominate the persistent HIV-1 proviral genome landscape. There are examples of RNA and protein expression...
Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models [0.03%]
利用CRISPR / dCas9-KRAB介导的HIV-1再激活抑制在淋巴和髓系细胞模型中的作用
Lendel Correia da Costa,Larissa Maciel Bomfim,Uilla Victoria Torres Dittz et al.
Lendel Correia da Costa et al.
Background: Despite antiretroviral treatment efficacy, it does not lead to the complete eradication of HIV infection. Consequently, reactivation of the virus from latently infected cell reservoirs is a major challenge tow...
Comprehensive identification and characterization of the HERV-K (HML-9) group in the human genome [0.03%]
人类基因组中HERV-K(HML-9)族的全面鉴定与表征
Lei Jia,Mengying Liu,Caiqin Yang et al.
Lei Jia et al.
Background: Human endogenous retroviruses (HERVs) result from ancestral infections caused by exogenous retroviruses that became incorporated into the germline DNA and evolutionarily fixed in the human genome. HERVs can be...
Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana [0.03%]
娱乐性大麻的抗炎作用在病毒抑制的HIV-1青年中被烟草产品联合使用逆转
Li Yin,Ashok R Dinasarapu,Samiksha A Borkar et al.
Li Yin et al.
Background: Marijuana's putative anti-inflammatory properties may benefit HIV-associated comorbidities. How recreational marijuana use affects gene expression in peripheral blood cells (PBC) among youth with HIV-1 (YWH) i...
P-selectin glycoprotein ligand-1 (PSGL-1/CD162) is incorporated into clinical HIV-1 isolates and can mediate virus capture and subsequent transfer to permissive cells [0.03%]
选择素glycoprotein配体-1（PSGL-1 / CD162）被临床HIV-1分离株捕获并介导病毒转移到易感细胞中
Jonathan Burnie,Arvin Tejnarine Persaud,Laxshaginee Thaya et al.
Jonathan Burnie et al.
Background: P-selectin glycoprotein ligand-1 (PSGL-1/CD162) has been studied extensively for its role in mediating leukocyte rolling through interactions with its cognate receptor, P-selectin. Recently, PSGL-1 was identif...
Marcelo López-Lastra,Vincent Parissi,Jean-Luc Darlix
Marcelo López-Lastra
No evidence of bovine leukemia virus proviral DNA and antibodies in human specimens from Japan [0.03%]
日本人体样本中未发现牛白血病病毒前病毒DNA和抗体
Meripet Polat Yamanaka,Susumu Saito,Yukiko Hara et al.
Meripet Polat Yamanaka et al.
Background: The potential risk and association of bovine leukemia virus (BLV) with human remains controversial as it has been reported to be both positive and negative in human breast cancer and blood samples. Therefore, ...
Immunoescape of HIV-1 in Env-EL9 CD8 + T cell response restricted by HLA-B*14:02 in a Non progressor who lost twenty-seven years of HIV-1 control [0.03%]
HLA-B*14:02限制的Env-EL9 CD8+ T细胞反应介导的HIV-1免疫逃逸：来自一位失去27年病毒控制功能的非进展者的证据
Ana Moyano,Oscar Blanch-Lombarte,Laura Tarancon-Diez et al.
Ana Moyano et al.
Background: Long-Term Non-Progressors (LTNPs) are untreated Human Immunodeficiency virus type 1 (HIV-1) infected individuals able to control disease progression for prolonged periods. However, the LTNPs status is temporar...
Case Reports
Retrovirology. 2022 Mar 26;19(1):6. DOI:10.1186/s12977-022-00591-7 2022
Correction to: A novel Betaretrovirus discovered in cattle with neurological disease and encephalitis [0.03%]
Correction to：在患有神经疾病和脑炎的奶牛中发现的一种新型贝塔逆转录病毒
Melanie M Hierweger,Michel C Koch,Ronja V Kauer et al.
Melanie M Hierweger et al.
Published Erratum
Retrovirology. 2022 Feb 7;19(1):5. DOI:10.1186/s12977-022-00590-8 2022
YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity [0.03%]
YTHDC1调控HIV-1复制的转录后整合步骤并影响其感染力
Sarah N&#x;Da Konan,Emmanuel Ségéral,Fabienne Bejjani et al.
Sarah N&#x;Da Konan et al.
Background: The recent discovery of the role of m6A methylation in the regulation of HIV-1 replication unveiled a novel layer of regulation for HIV gene expression. This epitranscriptomic modification of HIV-1 RNAs is und...