Genetic and transcriptomic signatures of host control in HIV-1 infection [0.03%]
HIV-1感染中宿主控制的基因和转录组标志物
Sergey Oreshkov,Christian W Thorball,Jenny Meylan et al.
Sergey Oreshkov et al.
Background: The interaction between HIV-1 and the host immune system plays a crucial role in the natural control and progression of the infection. Previous studies have identified APOBEC3G, Tetherin, SAMHD1, and SERINC5 a...
Metabolic reprogramming of CD4⁺ T cells by Zaprinast induces HIV-1 latency reversal ex vivo [0.03%]
Zaprinast通过代谢重塑CD4⁺T细胞诱导体内HIV-1潜伏逆转
V De Masson d&#x;Autume,V LeDouce,A Dutilleul et al.
V De Masson d&#x;Autume et al.
Background: HIV-1 latency and persistence of viral reservoirs within memory CD4+ T cells remain a fundamental obstacle to achieving a cure despite suppressive antiviral treatments. HIV-1 persistence is sustained by the dy...
Alan N Engelman
Alan N Engelman
Background: Antiretroviral inhibitors that target specific aspects of human immunodeficiency virus 1 (HIV-1) replication have made a huge impact on the management of the global AIDS pandemic and the health and well-being ...
Functional dissection of the prototype foamy virus glycoprotein heparan sulfate binding site [0.03%]
原型泡状病毒糖蛋白硫酸肝素结合位点的功能解析
Max Büttrich,Nicole Stanke-Scheffler,Thomas Calcraft et al.
Max Büttrich et al.
Background: The foamy virus (FV) glycoprotein complex (GPC) facilitates exceptionally broad species and tissue tropism. While cell surface heparan sulfate (HS) serves as a known attachment factor, it is not essential for ...
Carine Van Lint
Carine Van Lint
Versatile HIV Rev-dependent reporter cell system for stringent and sensitive quantification of viral reservoirs, neutralizing antibodies, and restriction factors [0.03%]
一种用于严格而灵敏地量化病毒库、中和抗体和限制因子的多功能HIV Rev依赖性报告细胞系统
Mark Spear,Joseph Choi,Brian Hetrick et al.
Mark Spear et al.
Detecting and measuring HIV reservoirs, neutralizing antibodies, and restriction factors are important for HIV cure research and the development of new therapeutics and vaccines. Here we describe the development and validation of several HI...
Human betaretrovirus (HBRV), homologous to mouse mammary tumor virus (MMTV), and human breast cancer: a significant epidemiological association [0.03%]
与小鼠乳腺肿瘤病毒同源的人贝塔逆转录病毒(HBRV)和人类乳腺癌：重要的流行病学关联
Fateme Saeedi-Moghaddam,Nazila Saffarian,Sayed-Hamidreza Mozhgani
Fateme Saeedi-Moghaddam
Background: Breast cancer is the most commonly diagnosed cancer globally. The potential role of oncogenic viruses, particularly Human Betaretrovirus (HBRV, formerly MMTV-LV/HMTV), in the pathogenesis of breast cancer has ...
Investigation of the expression level of human endogenous retrovirus E env transcript in cervical cancer [0.03%]
人类内源性逆转录病毒E型环境转录物在宫颈癌中的表达研究
Shaghayegh Jahanshahi,Rahim Soleimani-Jelodar,Somayeh Jalilvand et al.
Shaghayegh Jahanshahi et al.
Although HPV infection is obligatory for almost all cases of cervical cancer (CC), other risk factors can promote the progression of cervical cancer. In this context, the expression of human endogenous retroviruses (HERVs) in the developmen...
Strand-specific detection of cell-associated sense and antisense HIV-1 RNAs in splenocytes and PBMC from PLWH [0.03%]
PLWH脾细胞和外周血单个核细胞中细胞相关正链和反义HIV-1 RNA的链特异性检测方法
Laetitia Waast,Aurélien Geronimi,Adeline Mélard et al.
Laetitia Waast et al.
Background: Variation in the level of cell-associated HIV-1 RNA is an important parameter followed in clinical trials focusing on HIV-1 infection, latency or reactivation. In addition to sense products, HIV-1 also express...
Transcriptome mining reveals diversity and evolution of circulating and endogenous amphibian retroviruses [0.03%]
转录组测序挖掘揭示了循环和内源两栖动物逆转录病毒的多样性和进化
Emma F Harding,Banjo Webster,Tanu Sridhar et al.
Emma F Harding et al.
Background: The evolutionary history of retroviruses and their impact on vertebrate evolution remains poorly understood, particularly in non-mammalian hosts. In this study, we explore retroviruses associated with Amphibia...