HUSH-mediated HIV silencing is independent of TASOR phosphorylation on threonine 819 [0.03%]
由TASOR胸苷酸合成酶调节剂的第819苏氨酰残基磷酸化介导的病毒沉默对HUSH蛋白无影响
Virginie Vauthier,Angélique Lasserre,Marina Morel et al.
Virginie Vauthier et al.
Background: TASOR, a component of the HUSH repressor epigenetic complex, and SAMHD1, a cellular triphosphohydrolase (dNTPase), are both anti-HIV proteins antagonized by HIV-2/SIVsmm Viral protein X. As a result, the same ...
A clinical review of HIV integrase strand transfer inhibitors (INSTIs) for the prevention and treatment of HIV-1 infection [0.03%]
HIV整合酶链转移抑制剂(INSTIs)的临床应用评价：用于预防和治疗HIV-1感染
Alexa Vyain Zhao,Rustin D Crutchley,Rakesh Chowdary Guduru et al.
Alexa Vyain Zhao et al.
Integrase strand transfer inhibitors (INSTIs) have improved the treatment of human immunodeficiency virus (HIV). There are currently four approved for use in treatment-naïve individuals living with HIV; these include first generation ralte...
Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP [0.03%]
人类肺巨噬细胞和单核细胞中存在复制型HIV-1，尽管脱氧核糖核苷酸池中去氧尿苷三磷酸升高
Junru Cui,Mesfin Meshesha,Natela Churgulia et al.
Junru Cui et al.
Background: Although CD4+ memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue macrophages in both animal and human studies. During in vitro HIV infec...
Retrovirology Editorial
Retrovirology Editorial
The key amino acid sites 199-205, 269, 319, 321 and 324 of ALV-K env contribute to the weaker replication capacity of ALV-K than ALV-A [0.03%]
ALV-K env中的关键氨基酸位点199-205、269、319、321和324导致ALV-K的复制能力弱于ALV-A
Jian Chen,Jinqun Li,Xinyi Dong et al.
Jian Chen et al.
Background: Avian leukosis virus (ALV) is an infectious retrovirus, that mainly causes various forms of tumours, immunosuppression, a decreased egg production rate and slow weight gain in poultry. ALV consists of 11 subgr...
Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency [0.03%]
CLK丝氨酸/苏氨酸激酶在控制HIV-1基因表达和潜伏期中的拮抗作用
Subha Dahal,Kiera Clayton,Terek Been et al.
Subha Dahal et al.
Background: The generation of over 69 spliced HIV-1 mRNAs from one primary transcript by alternative RNA splicing emphasizes the central role that RNA processing plays in HIV-1 replication. Control is mediated in part thr...
CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection [0.03%]
利用CRISPR/Cas9基因编辑技术建立非人灵长类模式动物以研究HIV感染的干细胞治疗效应
Jenna Kropp Schmidt,Matthew R Reynolds,Thaddeus G Golos et al.
Jenna Kropp Schmidt et al.
Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologi...
Franziska K Geis,Demetra P Kelenis,Stephen P Goff
Franziska K Geis
Mammalian cells mount a variety of defense mechanisms against invading viruses to prevent or reduce infection. One such defense is the transcriptional silencing of incoming viral DNA, including the silencing of unintegrated retroviral DNA i...
Rebecca M Olson,Germán Gornalusse,Leanne S Whitmore et al.
Rebecca M Olson et al.
Background: Innate immunity and type 1 interferon (IFN) defenses are critical for early control of HIV infection within CD4 + T cells. Despite these defenses, some acutely infected cells silence viral transcription to bec...
Interview with a Retrovirologist: Wibke Bayer in conversation with Hung Fan [0.03%]
专访逆转录病毒学家：Wibke Bayer 与 Hung Fan 对谈
Hung Fan,Wibke Bayer
Hung Fan