Walther Mothes
Walther Mothes
A gut check: understanding the interplay of the gastrointestinal microbiome and the developing immune system towards the goal of pediatric HIV remission [0.03%]
肠道检查：理解胃肠微生物组与发育中的免疫系统之间的相互作用，以实现儿科HIV缓解的目标
Nicole Soo,Omotayo Farinre,Ann Chahroudi et al.
Nicole Soo et al.
Despite the efficacy of antiretroviral therapy (ART) in reducing the global incidence of vertical HIV transmissions, more than 120,000 children are still infected with the virus each year. Since ART cannot clear the HIV reservoir that is es...
High level of genomic divergence in orf-I p12 and hbz genes of HTLV-1 subtype-C in Central Australia [0.03%]
中央澳大利亚HTLV-1亚型C系orf-I p12和hbz基因的高遗传差异性
Ashley Hirons,David Yurick,Natasha Jansz et al.
Ashley Hirons et al.
Background: Human T cell lymphotropic virus type 1 (HTLV-1) infection remains a largely neglected public health problem, particularly in resource-poor areas with high burden of communicable and non-communicable diseases, ...
In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection [0.03%]
HIV-1感染过程中的原位神经元损伤及神经炎症分析
Jenna B Honeycutt,Angela Wahl,Jacob K Files et al.
Jenna B Honeycutt et al.
Background: Since the introduction of combination antiretroviral therapy (cART) the brain has become an important human immunodeficiency virus (HIV) reservoir due to the relatively low penetration of many drugs utilized i...
Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome [0.03%]
逆转录病毒Gag与宿主细胞相互作用的比较分析：重点关注核内相互作用系统综述
Gregory S Lambert,Breanna L Rice,Rebecca J Kaddis Maldonado et al.
Gregory S Lambert et al.
Retroviruses exploit host proteins to assemble and release virions from infected cells. Previously, most studies focused on interacting partners of retroviral Gag proteins that localize to the cytoplasm or plasma membrane. Given that severa...
Comparative Study
Retrovirology. 2024 Jun 19;21(1):13. DOI:10.1186/s12977-024-00645-y 2024
Retroviral PBS-segment sequence and structure: Orchestrating early and late replication events [0.03%]
逆转录病毒PBS区段序列与结构：调控早期和晚期复制事件
Xiao Heng,Amanda Paz Herrera,Zhenwei Song et al.
Xiao Heng et al.
An essential regulatory hub for retroviral replication events, the 5' untranslated region (UTR) encodes an ensemble of cis-acting replication elements that overlap in a logical manner to carry out divergent RNA activities in cells and in vi...
Rebecca P Sumner,Henry Blest,Meiyin Lin et al.
Rebecca P Sumner et al.
Background: Detection of viruses by host pattern recognition receptors induces the expression of type I interferon (IFN) and IFN-stimulated genes (ISGs), which suppress viral replication. Numerous studies have described H...
Inhibition of caspase pathways limits CD4+ T cell loss and restores host anti-retroviral function in HIV-1 infected humanized mice with augmented lymphoid tissue [0.03%]
抑制半胱氨酸天冬氨酸蛋白酶途径可限制HIV-1感染的免疫重建不良小鼠模型中的CD4阳性T细胞损失并恢复宿主抗逆转录病毒功能
Alex J Holloway,Tais B Saito,Kubra F Naqvi et al.
Alex J Holloway et al.
The study of HIV infection and pathogenicity in physical reservoirs requires a biologically relevant model. The human immune system (HIS) mouse is an established model of HIV infection, but defects in immune tissue reconstitution remain a c...
Correction: YTHDC1 regulates distinct post-integration steps of HIV-1 replication and is important for viral infectivity [0.03%]
纠正：YTHDC1调控HIV-1复制的不同期步骤并对其感染性产生重要影响
Sarah N&#x;Da Konan,Emmanuel Ségéral,Fabienne Bejjani et al.
Sarah N&#x;Da Konan et al.
Published Erratum
Retrovirology. 2024 Apr 30;21(1):9. DOI:10.1186/s12977-024-00642-1 2024
HERV-W upregulation expression in bipolar disorder and schizophrenia: unraveling potential links to systemic immune/inflammation status [0.03%]
与系统性免疫/炎症状态相关的双相情感障碍和精神分裂症中HERV-W上调表达及其潜在联系
Sara Coelho Rangel,Michelly Damasceno da Silva,Décio Gilberto Natrielli Filho et al.
Sara Coelho Rangel et al.
Background: Bipolar disorder (BD) and schizophrenia (SZ) are the two main mental disorders with unknown etiology that significantly impact individuals' quality of life. The potential pro-inflammatory role in their pathoge...