Editing out HIV: application of gene editing technology to achieve functional cure [0.03%]
基因编辑治艾滋：功能性治愈艾滋病的基因组编辑技术及其应用
Jingna Xun,Xinyu Zhang,Shuyan Guo et al.
Jingna Xun et al.
Highly active antiretroviral therapy (HAART) successfully suppresses human immunodeficiency virus (HIV) replication and improves the quality of life of patients living with HIV. However, current HAART does not eradicate HIV infection becaus...
Trim28 acts as restriction factor of prototype foamy virus replication by modulating H3K9me3 marks and destabilizing the viral transactivator Tas [0.03%]
Trim28通过调节H3K9me3印记和破坏病毒转激活子Tas的稳定性来抑制原型泡沫病毒的复制
Peipei Yuan,Jun Yan,Shuang Wang et al.
Peipei Yuan et al.
Background: Prototype foamy virus (PFV) is nonpathogenic complex retroviruses that express a transcriptional transactivator Tas, which is essential for the activity of viral long terminal repeat (LTR) promoter and interna...
HIV-1 integrase binding to genomic RNA 5'-UTR induces local structural changes in vitro and in virio [0.03%]
HIV-1整合酶与基因组RNA 5'-UTR的结合在体外和病毒中引起局部结构变化
Shuohui Liu,Pratibha C Koneru,Wen Li et al.
Shuohui Liu et al.
Background: During HIV-1 maturation, Gag and Gag-Pol polyproteins are proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid lattice. HIV-1 integrase (IN) binds the viral genomic RNA (gRNA...
An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation [0.03%]
隐藏在哺乳动物基因组中的古老逆转录病毒RNA元件及其在同源逆转录病毒基因调节中的作用
Koichi Kitao,So Nakagawa,Takayuki Miyazawa
Koichi Kitao
Background: Retroviruses utilize multiple unique RNA elements to control RNA processing and translation. However, it is unclear what functional RNA elements are present in endogenous retroviruses (ERVs). Gene co-option fr...
Diverse antiviral IgG effector activities are predicted by unique biophysical antibody features [0.03%]
独特的生物物理抗体特征可预测多种抗病毒IgG效应子活性
Hao D Cheng,Karen G Dowell,Chris Bailey-Kellogg et al.
Hao D Cheng et al.
Background: The critical role of antibody Fc-mediated effector functions in immune defense has been widely reported in various viral infections. These effector functions confer cellular responses through engagement with i...
Integration of SARS-CoV-2 RNA in infected human cells by retrotransposons: an unlikely hypothesis and old viral relationships [0.03%]
逆转座子使SARS-CoV-2 RNA在感染的人细胞中整合：一个不太可能的假说和古老的病毒关系
Nicole Grandi,Enzo Tramontano,Ben Berkhout
Nicole Grandi
Zhang et al. (Proc Natl Acad Sci 118:e2105968118, 2021) recently reported that SARS-CoV-2 RNA can be retrotranscribed and integrated into the DNA of human cells by the L1 retrotransposon machinery. This phenomenon could cause persistence of...
Residues T48 and A49 in HIV-1 NL4-3 Nef are responsible for the counteraction of autophagy initiation, which prevents the ubiquitin-dependent degradation of Gag through autophagosomes [0.03%]
HIV-1 NL4-3 Nef中的T48和A49残基负责对抗自噬的启动，从而防止Gag通过自噬溶酶体进行泛素依赖性降解
Sergio Castro-Gonzalez,Yuexuan Chen,Jared Benjamin et al.
Sergio Castro-Gonzalez et al.
Background: Autophagy plays an important role as a cellular defense mechanism against intracellular pathogens, like viruses. Specifically, autophagy orchestrates the recruitment of specialized cargo, including viral compo...
HIV-1 capsid variability: viral exploitation and evasion of capsid-binding molecules [0.03%]
HIV-1衣壳的可变性：病毒利用和逃避衣壳结合分子
Akatsuki Saito,Masahiro Yamashita
Akatsuki Saito
The HIV-1 capsid, a conical shell encasing viral nucleoprotein complexes, is involved in multiple post-entry processes during viral replication. Many host factors can directly bind to the HIV-1 capsid protein (CA) and either promote or prev...
Altered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators [0.03%]
改变Env构象动力学作为抵抗肽-三唑HIV-1灭活剂的机制
Shiyu Zhang,Andrew P Holmes,Alexej Dick et al.
Shiyu Zhang et al.
Background: We previously developed drug-like peptide triazoles (PTs) that target HIV-1 Envelope (Env) gp120, potently inhibit viral entry, and irreversibly inactivate virions. Here, we investigated potential mechanisms o...
Arginyl-tRNA-protein transferase 1 contributes to governing optimal stability of the human immunodeficiency virus type 1 core [0.03%]
氨基酰-tRNA-蛋白转移酶1有助于调控人类免疫缺陷病毒核心的最优稳定性
Naoki Kishimoto,Ryosuke Okano,Ayano Akita et al.
Naoki Kishimoto et al.
Background: The genome of human immunodeficiency virus type 1 (HIV-1) is encapsulated in a core consisting of viral capsid proteins (CA). After viral entry, the HIV-1 core dissociates and releases the viral genome into th...