FKBP25 regulates myoblast viability and migration and is differentially expressed in in vivo models of muscle adaptation [0.03%]
FKBP25调节肌管的存活和迁移，并在体内肌肉适应模型中差异表达
Tabitha Cree,Tania Ruz Gomez,Cara A Timpani et al.
Tabitha Cree et al.
FKBP25 (FKBP3 gene) is a dual-domain PPIase protein that consists of a C-terminal PPIase domain and an N-terminal basic tilted helix bundle (BTHB). The PPIase domain of FKBP25 has been shown to bind to microtubules, which has impacts upon m...
Asp179 in the class A β-lactamase from Mycobacterium tuberculosis is a conserved yet not essential residue due to epistasis [0.03%]
结核分枝杆菌中一类β-内酰胺酶的第179位ASP是由于表型隐性而保守但非必需的氨基酸残基
Ilona van Alen,Aleksandra Chikunova,Danny B van Zanten et al.
Ilona van Alen et al.
Conserved residues are often considered essential for function, and substitutions in such residues are expected to have a negative influence on the properties of a protein. However, mutations in a few highly conserved residues of the β-lac...
A CRISPR/Cas9-based multicopy integration system for protein production in Aspergillus niger [0.03%]
基于CRISPR / Cas9的里氏木霉多拷贝整合系统用于蛋白质生产
Mark Arentshorst,Prajeesh Kooloth Valappil,László Mózsik et al.
Mark Arentshorst et al.
The filamentous fungus Aspergillus niger is well known for its high protein secretion capacity and a preferred host for homologous and heterologous protein production. To improve the protein production capacity of A. niger even further, a s...
Non-canonical nucleosides: Biomimetic triphosphorylation, incorporation into mRNA and effects on translation and structure [0.03%]
非经典核苷酸：类似生物合成的三磷酸化、掺入mRNA及对翻译和结构的影响
Patricia Benčić,Michael Keppler,Marco Kuge et al.
Patricia Benčić et al.
Recent advances in mRNA therapeutics demand efficient toolkits for the incorporation of nucleoside analogues into mRNA suitable for downstream applications. Herein, we report the application of a versatile enzyme cascade for the triphosphor...
The C-terminal domain of MinC, a cell division regulation protein, is sufficient to form a copolymer with MinD [0.03%]
细胞分裂调节蛋白MinC的C端结构域足以与MinD形成共聚体
Na Wang,Haiyu Sun,Kairui Zhao et al.
Na Wang et al.
Assembly of cell division protein FtsZ into the Z-ring at the division site is a key step in bacterial cell division. The Min proteins can restrict the Z-ring to the middle of the cell. MinC is the main protein that obstructs Z-ring formati...
Syntaxin 5-dependent phosphorylation of the small heat shock protein Hsp42 and its role in protein quality control [0.03%]
依赖于syntaxin 5的热休克蛋白Hsp42磷酸化及其在蛋白质质量控制中的作用
Doryaneh Ahmadpour,Navinder Kumar,Arthur Fischbach et al.
Doryaneh Ahmadpour et al.
The small heat shock protein Hsp42 and the t-SNARE protein Sed5 have central roles in the sequestration of misfolded proteins into insoluble protein deposits in the yeast Saccharomyces cerevisiae. However, whether these proteins/processes i...
Interleukin-1 family cytokines at the crossroads of microbiome regulation in barrier health and disease [0.03%]
屏障健康与疾病中的微生物群调节的交叉路口的白细胞介素-1家族细胞因子
Paloma Narros-Fernández,Shrikanth Chomanahalli Basavarajappa,Patrick T Walsh
Paloma Narros-Fernández
Recent advances in understanding how the microbiome can influence both the physiology and the pathogenesis of disease in humans have highlighted the importance of gaining a deeper insight into the complexities of the host-microbial dialogue...
Alyson M Curry,Stacia Rymarchyk,Noah B Herrington et al.
Alyson M Curry et al.
Human sirtuins play important roles in various cellular events including DNA repair, gene silencing, mitochondrial biogenesis, insulin secretion and apoptosis. They regulate a wide array of protein and enzyme targets through their NAD+ -dep...
Resolving domain positions of cellobiose dehydrogenase by small angle X-ray scattering [0.03%]
利用小角度X射线散射解析纤维二糖脱氢酶的结构domains位置
Bettina Motycka,Florian Csarman,Rupert Tscheliessnig et al.
Bettina Motycka et al.
The interdomain electron transfer (IET) between the catalytic flavodehydrogenase domain and the electron-transferring cytochrome domain of cellobiose dehydrogenase (CDH) plays an essential role in biocatalysis, biosensors and biofuel cells,...
Biophysical and biochemical nature of amorphous protein oligomers determines the strength of immune response and the generation of T-cell memory [0.03%]
无定形蛋白寡聚体的生物物理和生化性质决定了免疫反应强度和T细胞记忆的产生
Md Golam Kibria,Yukari Shiwaku,Subbaian Brindha et al.
Md Golam Kibria et al.
Here, we used domain 3 of dengue virus serotype 3 envelope protein (D3ED3), a natively folded globular low-immunogenicity protein, to ask whether the biophysical nature of amorphous oligomers can affect immunogenicity. We prepared nearly id...