Lysosome pH-regulated H+ /K+ switching channel involved in maintaining lysosomal homeostasis [0.03%]
溶酶体pH调控的质子/钾离子交换通道在维持溶酶体稳态中的作用
Yizhen Wang,Wei Li,Qiaochu Wang
Yizhen Wang
Lysosomal pH setpoint and H+ homeostasis is key to the lysosome's functions. The Parkinson's disease-risk protein TMEM175, originally identified as lysosomal K+ channel, works as a H+ -activated H+ channel and discharges the lysosomal H+ st...
Metabolite-derived damage-associated molecular patterns in immunological diseases [0.03%]
免疫性疾病中的代谢衍生的损伤相关分子模式
Na Kang,Zhenglin Ji,Yuxin Li et al.
Na Kang et al.
Damage-associated molecular patterns (DAMPs) are typically derived from the endogenous elements of necrosis cells and can trigger inflammatory responses by activating DAMPs-sensing receptors on immune cells. Failure to clear DAMPs may lead ...
Pharmacological profiling identifies divergent chemosensitivities of differentiating and maturing iPSC-derived human cortical neuron populations [0.03%]
药理学特征分析鉴别出不同分化阶段诱导多能干细胞来源的人类皮层神经元群体的不同的化疗敏感性
Elizabeth R Sharlow,Danielle C Llaneza,Bhanu P Tewari et al.
Elizabeth R Sharlow et al.
Neuronal differentiation and maturation are extended developmental processes. To determine whether neurons at different developmental stages have divergent chemosensitivities, we screened differentiating and maturing neuronal populations us...
Modelling the distinct roles of epithelial and stromal androgen receptor in the regulation of prostate epithelial dynamics [0.03%]
前列腺上皮动力学调控中表皮和间充质雄激素受体的不同作用机制的建模
Isabel L Woodman
Isabel L Woodman
The prostate is an androgen-responsive organ, but the complex cellular and molecular interactions that mediate these responses remain incompletely defined. Here, I synthesise the existing literature to derive a simple conceptual framework d...
M Fethullah Simsek,Ertuğrul M Özbudak
M Fethullah Simsek
Multitudes of organisms display metameric compartmentalization of their body plan. Segmentation of these compartments happens sequentially in diverse phyla. In several sequentially segmenting species, periodically active molecular clocks an...
Cytosolic malic enzyme and glucose-6-phosphate dehydrogenase modulate redox balance in NSCLC with acquired drug resistance [0.03%]
细胞苹果酸酶和葡萄糖-6-磷酸脱氢酶调节获得性耐药NSCLC的氧化还原平衡
Maoxin Ran,Yan Zhou,Yizhen Guo et al.
Maoxin Ran et al.
Lung cancer cells often show elevated levels of reactive oxygen species (ROS) and nicotinamide adenine dinucleotide phosphate (NADPH). However, the connections between deregulated redox homeostasis in different subtypes of lung cancer and a...
W Brent Derry
W Brent Derry
Developmental programs are tightly regulated networks of molecular and cellular signaling pathways that orchestrate the formation and organization of tissues and organs during organismal development. However, these programs can be disrupted...
Identification and characterization of archaeal and bacterial F420 -dependent thioredoxin reductases [0.03%]
古细菌和细菌F420依赖型硫氧还蛋白还原酶的鉴定与表征
Guang Yang,Hein J Wijma,Henriëtte J Rozeboom et al.
Guang Yang et al.
The thioredoxin pathway is an antioxidant system present in most organisms. Electrons flow from a thioredoxin reductase to thioredoxin at the expense of a specific electron donor. Most known thioredoxin reductases rely on NADPH as a reducin...
Structure elucidation and characterization of patulin synthase, insights into the formation of a fungal mycotoxin [0.03%]
帕妥霉素合成酶的结构阐明与表征及其在真菌毒素生物合成中的作用机制研究
Gwen Tjallinks,Alessandro Boverio,Ivana Maric et al.
Gwen Tjallinks et al.
Patulin synthase (PatE) from Penicillium expansum is a flavin-dependent enzyme that catalyses the last step in the biosynthesis of the mycotoxin patulin. This secondary metabolite is often present in fruit and fruit-derived products, causin...
Structural insights into the ligand binding domain of GluD1 and GluD2 receptors [0.03%]
谷氨酸门控阳离子通道GluD1和GluD2受体配体结合域的结构研究
Ludovic Tricoire,Régine Hepp
Ludovic Tricoire
GluD1 and GluD2 subunits (also known as delta 1 and 2) are the members of the delta family of ionotropic glutamate receptors. They are particularly puzzling, since they are unable to bind glutamate, but rather bind glycine and d-serine via ...