Comparative study of the molecular mechanisms underlying the G protein and β-arrestin-dependent pathways that lead to ERKs activation upon stimulation by dopamine D2 receptor [0.03%]
多巴胺D2受体激活ERKs的G蛋白和β- arrestin途径的分子机制的比较研究
Haiping Liu,Srijan Acharya,Sarabjeet Kour Sudan et al.
Haiping Liu et al.
Dopamine D2 receptor (D2 R) has been shown to activate extracellular signal-regulated kinases (ERKs) via distinct pathways dependent on either G-protein or β-arrestin. However, there has not been a systematic study of the regulatory proces...
Comparative Study
The FEBS journal. 2023 Nov;290(21):5204-5233. DOI:10.1111/febs.16921 2023
Arsenic affects homologous recombination and single-strand annealing but not end-joining pathways during DNA double-strand break repair [0.03%]
砷影响DNA双链断裂修复过程中同源重组和单链连接但不影响末端连接途径
Aya Kurosawa,Shinta Saito,Mikiko Sakurai et al.
Aya Kurosawa et al.
Arsenic is a carcinogen that can cause skin, lung, and bladder cancer. While DNA double-strand breaks (DSBs) have been implicated in arsenic-induced carcinogenesis, the exact mechanism remains unclear. In this study, we performed genetic an...
Identification of a small chemical as a lysosomal calcium mobilizer and characterization of its ability to inhibit autophagy and viral infection [0.03%]
一种小分子化合物被鉴定为溶酶体钙动员剂并研究了其抑制自噬和病毒入侵的能力
Kehui Zhang,Lihong Huang,Yang Cai et al.
Kehui Zhang et al.
We previously identified glyceraldehyde 3-phosphate dehydrogenase (GAPDH) as one of the cyclic adenosine diphosphoribose (cADPR)'s binding proteins and found that GAPDH participates in cADPR-mediated Ca2+ release from endoplasmic reticulum ...
Lev Khmelnitsky,Ayala Milo,Orly Dym et al.
Lev Khmelnitsky et al.
CysD domains are disulfide-rich modules embedded within long O-glycosylated regions of mucin glycoproteins. CysD domains are thought to mediate intermolecular adhesion during the intracellular bioassembly of mucin polymers and perhaps also ...
CUL3 induces mitochondrial dysfunction via MRPL12 ubiquitination in renal tubular epithelial cells [0.03%]
CUL3通过MRPL12泛素化诱导肾小管上皮细胞线粒体功能障碍
Xingzhao Ji,Xiaoli Yang,Xia Gu et al.
Xingzhao Ji et al.
Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease worldwide and the strongest predictor of mortality in patients with diabetes. Despite its significance, the pathological mechanism underlying the onset and progres...
Skeletal muscle-enriched miRNAs are highly unstable in vivo and may be regulated in a Dicer-independent manner [0.03%]
骨骼肌丰富型微小核糖核酸在生物体内极不稳定且可能以不含迪凯酶的方式进行调控
Satoshi Oikawa,Shuaibang Yuan,Yoshio Kato et al.
Satoshi Oikawa et al.
MicroRNAs (miRNAs) are small noncoding RNAs that control essential cellular processes. For several decades, the molecular mechanisms underlying the functions and biogenesis of miRNAs have been clarified, whereas the molecular dynamics of mi...
Reaction mechanism and kinetics of the two-component flavoprotein dimethyl sulfone monooxygenase system: Using hydrogen peroxide for monooxygenation and substrate cleavage [0.03%]
二组分黄素蛋白二甲基砜单加氧酶体系的反应机理和动力学：利用过氧化氢进行单加氧作用和底物切断反应
Montisa Mangkalee,Worrapoj Oonanant,Chanat Aonbangkhen et al.
Montisa Mangkalee et al.
The dimethyl sulfone monooxygenase system is a two-component flavoprotein, catalyzing the monooxygenation of dimethyl sulfone (DMSO2 ) by oxidative cleavage producing methanesulfinate and formaldehyde. The reductase component (DMSR) is a fl...
Rafoxanide, a salicylanilide anthelmintic, interacts with human plasma protein transthyretin [0.03%]
药物莫西克丁与人血浆蛋白转运蛋白的相互作用研究
Takeshi Yokoyama,Mineyuki Mizuguchi,Yuko Nabeshima et al.
Takeshi Yokoyama et al.
Transthyretin (TTR) is a carrier protein for thyroid hormone thyroxine (T4 ) in plasma, placental cytosol, and cerebrospinal fluid. While the potential toxicity of small molecules that compete with T4 for binding to TTR should be carefully ...
The E3 ligase DTX2 inhibits RUNX1 function by binding its C terminus and prevents the growth of RUNX1-dependent leukemia cells [0.03%]
E3连接酶DTX2通过结合其C端抑制RUNX1功能并阻止依赖RUNX1的白血病细胞增殖
Taishi Yonezawa,Hirotaka Takahashi,Yangying Hao et al.
Taishi Yonezawa et al.
Transcription factor RUNX1 plays important roles in hematopoiesis and leukemogenesis. RUNX1 function is tightly controlled through posttranslational modifications, including ubiquitination and acetylation. However, its regulation via ubiqui...
Insights into the mechanisms of neuron generation and specification in the zebrafish ventral spinal cord [0.03%]
脊椎鱼侧板神经生成和规范机制的洞察
Gokhan Cucun,Melina Köhler,Sabrina Pfitsch et al.
Gokhan Cucun et al.
The vertebrate nervous system is composed of a wide range of neurons and complex synaptic connections, raising the intriguing question of how neuronal diversity is generated. The spinal cord provides an excellent model for exploring the mec...