Rucaparib inhibits lung adenocarcinoma cell proliferation and migration via the SHCBP1/CDK1 pathway [0.03%]
鲁卡帕尼通过SHCBP1/CDK1通路抑制肺腺癌细胞增殖和迁移
Yue Dai,Changpeng Hu,Huyue Zhou et al.
Yue Dai et al.
Src homolog and collagen homolog binding protein 1 (SHCBP1) binds to the SH2 domain of SHC-transforming protein 1 (SHC1) and is involved in midbody organization and cytokinesis completion. SHCBP1 has been reported to be a cancer driver gene...
Comparative functional and structural analysis of Pseudomonas aeruginosa d-alanine-d-alanine ligase isoforms as prospective antibiotic targets [0.03%]
铜绿假单胞菌d-丙氨酸:d-丙氨酸连接酶同工酶的功能和结构分析及其作为抗生素靶点的前景研究
Jordan L Pederick,Jessica C Woolman,John B Bruning
Jordan L Pederick
Pseudomonas aeruginosa is a major human pathogen in the healthcare setting. The emergence of multi-drug-resistant and extensive drug-resistant P. aeruginosa is of great concern, and clearly indicates that new alternatives to current first-l...
Hepatocyte reprogramming in liver regeneration: Biological mechanisms and applications [0.03%]
肝细胞重编程在肝脏再生中的作用：生物学机制及应用前景
Mengmeng Jiang,Jie Ren,Juan Carlos Izpisua Belmonte et al.
Mengmeng Jiang et al.
The liver is one of the few organs that retain the capability to regenerate in adult mammals. This regeneration process is mainly facilitated by the dynamic behavior of hepatocytes, which are the major functional constituents in the liver. ...
Ryota Kawahara,Tomoko Usami,Satoko Arakawa et al.
Ryota Kawahara et al.
Premelanosome protein (PMEL), a melanocyte-specific glycoprotein, has an essential role in melanosome maturation, assembling amyloid fibrils for melanin deposition. PMEL undergoes several post-translational modifications, including N- and O...
Neutrophil extracellular traps boost laser-induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF-1α pathway [0.03%]
中性粒细胞胞外诱捕网通过激活脉络膜内皮细胞TLR4/HIF-1α通路上调激光诱导的小鼠脉络膜新生血管形成
Jia Zeng,Ying Wang,Manhui Zhu et al.
Jia Zeng et al.
Choroidal neovascularization (CNV) is characterized by the infiltration of immune cells, particularly neutrophils. Neutrophil extracellular trap (NET) facilitates the angiogenesis of pulmonary endothelial cells via activating Toll-like rece...
Cardiomyocyte external mechanical unloading activates modifications of α-actinin differently from sarcomere-originated unloading [0.03%]
心室辅助下的机械卸载与肌小节张力降低所诱发的心肌细胞α-actinin的修饰不同
Christopher Solís,Chad M Warren,Kyle Dittloff et al.
Christopher Solís et al.
Loss of myocardial mass in a neonatal rat cardiomyocyte culture is studied to determine whether there is a distinguishable cellular response based on the origin of mechano-signals. The approach herein compares the sarcomeric assembly and di...
YAP co-localizes with the mitotic spindle and midbody to safeguard mitotic division in lung-cancer cells [0.03%]
YAP与有丝分裂纺锤体和中体共定位，以保障肺癌细胞的有丝分裂
Shu-Er Chow,Chia-Chi Hsu,Cheng-Ta Yang et al.
Shu-Er Chow et al.
YES-associated protein (YAP) is a part of the Hippo pathway, with pivotal roles in several developmental processes and dual functionality as both a tumor suppressor and an oncogene. In the present study, we identified YAP activity as a micr...
The metagenome-derived esterase PET40 is highly promiscuous and hydrolyses polyethylene terephthalate (PET) [0.03%]
从元基因组衍生的酯酶PET40具有高度的底物普适性并可水解聚对苯二甲酸乙二醇酯(PET)
Hongli Zhang,Robert F Dierkes,Pablo Perez-Garcia et al.
Hongli Zhang et al.
Polyethylene terephthalate (PET) is a widely used synthetic polymer and known to contaminate marine and terrestrial ecosystems. Only few PET-active microorganisms and enzymes (PETases) are currently known, and it is debated whether degradat...
FEBS Journal Editorial Team;Daniel B Longley
FEBS Journal Editorial Team;Daniel B Longley
In this special interview series, we profile members of The FEBS Journal editorial board to highlight their research focus, perspectives on the journal and future directions in their field. Professor Daniel Longley is the Director of the Pa...
The protease ADAM17 at the crossroads of disease: revisiting its significance in inflammation, cancer, and beyond [0.03%]
介蛋白酶ADAM17在疾病中的十字路口：重新审视其在炎症、癌症等领域的意义
Mohamed I Saad,Brendan J Jenkins
Mohamed I Saad
The protease A Disintegrin And Metalloproteinase 17 (ADAM17) plays a central role in the pathophysiology of several diseases. ADAM17 is involved in the cleavage and shedding of at least 80 known membrane-tethered proteins, which subsequentl...