The role of SPP/SPPL intramembrane proteases in membrane protein homeostasis [0.03%]
SPP/SPPL跨膜蛋白酶在调节膜蛋白稳态中的作用
Torben Mentrup,Nadja Leinung,Mehul Patel et al.
Torben Mentrup et al.
Signal peptide peptidase (SPP) and the four SPP-like proteases SPPL2a, SPPL2b, SPPL2c and SPPL3 constitute a family of aspartyl intramembrane proteases with homology to presenilins. The different members reside in distinct cellular localisa...
Molecular basis of selective amyloid-β degrading enzymes in Alzheimer's disease [0.03%]
阿尔茨海默病选择性降解淀粉样蛋白-β的分子基础
Joanna Żukowska,Stephen J Moss,Vasanta Subramanian et al.
Joanna Żukowska et al.
The accumulation of the small 42-residue long peptide amyloid-β (Aβ) has been proposed as a major trigger for the development of Alzheimer's disease (AD). Within the brain, the concentration of Aβ peptide is tightly controlled through pr...
SND1, a novel co-activator of HIF1α, promotes tumor initiation in PyMT-induced breast tumor [0.03%]
新型HIF1α共激活因子SND1促进PyMT诱导的小鼠乳腺肿瘤发生
Lihong Hu,Yufeng Zeng,Lingbiao Xin et al.
Lihong Hu et al.
The multifunctional protein staphylococcal nuclease domain-containing protein 1 (SND1) is conserved and has been implicated in several aspects of tumor development, such as proliferation, epithelial-mesenchymal transition, and immune evasio...
Glow-type conversion and characterization of a minimal luciferase via mutational analyses [0.03%]
通过突变分析对最小萤光素酶进行Glow类型的转化和表征
Yuki Ohmuro-Matsuyama,Hayato Matsui,Masaki Kanai et al.
Yuki Ohmuro-Matsuyama et al.
Luciferases are widely used as reporter proteins in various fields. Recently, we developed a minimal bright luciferase, picALuc, via partial deletion of the artificial luciferase (ALuc) derived from copepods luciferases. However, the struct...
Extracellular matrix biomechanical roles and adaptation in health and disease [0.03%]
细胞外基质在健康和疾病中的生物力学作用及适应性
Marco Franchi,Zoi Piperigkou,Nicholas S Mastronikolis et al.
Marco Franchi et al.
Extracellular matrices (ECMs) are dynamic 3D macromolecular networks that exhibit structural characteristics and composition specific to different tissues, serving various biomechanical and regulatory functions. The interactions between ECM...
FEBS Journal Editorial Team;Arun K Shukla
FEBS Journal Editorial Team;Arun K Shukla
In this special interview series, we profile members of The FEBS Journal editorial board to highlight their research focus, perspectives on the journal, and future directions in their field. Professor Arun Shukla is a Senior Fellow of DBT W...
Metabolic characterisation of transglutaminase 2 inhibitor effects in breast cancer cell lines [0.03%]
乳腺癌细胞系中转谷氨酰胺酶2抑制剂的代谢表征
Mariana Gallo,Elena Ferrari,Anna Terrazzan et al.
Mariana Gallo et al.
Transglutaminase 2 (TG2), which mediates post-translational modifications of multiple intracellular enzymes, is involved in the pathogenesis and progression of cancer. We used 1 H-NMR metabolomics to study the effects of AA9, a novel TG2 in...
A simple bypass assay for DNA polymerases shows that cancer-associated hypermutating variants exhibit differences in vitro [0.03%]
一种简单的DNA聚合酶旁路测定法显示，癌症相关的高突变变异体在体外表现出差异
Gilles Crevel,Stephen Kearsey,Sue Cotterill
Gilles Crevel
Errors made by DNA polymerases contribute to both natural variation and, in extreme cases, genome instability and its associated diseases. Recently, the importance of polymerase misincorporation in disease has been highlighted by the identi...
Arabidopsis T-DNA mutants affected in TRDMT1/DNMT2 show differential protein synthesis and compromised stress tolerance [0.03%]
拟南芥突变体受TRDMT1/DNMT2影响显示不同的蛋白质合成和应激耐受性受损
Nikita Wadhwa,Sanjay Kapoor,Meenu Kapoor
Nikita Wadhwa
TRDMT1/DNMT2 belongs to the conserved family of nucleic acid methyltransferases. Unlike the animal systems, studies on TRDMT1/DNMT2 in land plants have been limited. We show that TRDMT1/DNMT2 is strongly conserved in the green lineage. Stud...
Defects of the spliceosomal gene SNRPB affect osteo- and chondro-differentiation [0.03%]
剪接体基因SNRPB缺陷影响软骨和骨细胞分化
Chris Knill,Ellie J Henderson,Craig Johnson et al.
Chris Knill et al.
Although gene splicing occurs throughout the body, the phenotype of spliceosomal defects is largely limited to specific tissues. Cerebro-costo-mandibular syndrome (CCMS) is one such spliceosomal disease, which presents as congenital skeleta...