Synaptotagmin-7 mediates cardiac hypertrophy by targeting autophagy [0.03%]
synaptotagmin-7通过调控自噬介导心室肥厚
Teng Sun,Yu Han,Jia-Lei Li et al.
Teng Sun et al.
Sustained cardiac hypertrophy damages the heart and weakens cardiac function, often leading to heart failure and even death. Pathological cardiac hypertrophy has become a central therapeutic target for many heart diseases including heart fa...
Anasuya Moitra,Vitasta Tiku,Doron Rapaport
Anasuya Moitra
Mitochondrial outer membrane β-barrel proteins are encoded in the nucleus, translated in the cytosol and then targeted to and imported into the respective organelles. Detailed studies have uncovered the mechanisms involved in the import of...
Tenzin Deyang,Md Awaise Iqbal Baig,Phurbu Dolkar et al.
Tenzin Deyang et al.
Sleep disorders are becoming increasingly common, and their distinct effects on physical and mental health require elaborate investigation. Gut dysbiosis (GD) has been reported in sleep-related disorders, but sleep apnoea is of particular s...
Yoshinori Takeuchi,Yuki Murayama,Yuichi Aita et al.
Yoshinori Takeuchi et al.
During periods of fasting, the body undergoes a metabolic shift from carbohydrate utilization to the use of fats and ketones as an energy source, as well as the inhibition of de novo lipogenesis and the initiation of gluconeogenesis in the ...
Novel tetrahydrofolate-dependent d-serine dehydratase activity of serine hydroxymethyltransferases [0.03%]
丝氨酸羟甲基转移酶的新四氢叶酸依赖性的d-丝氨酸脱水酶活性
Tetsuya Miyamoto,Shinya Fushinobu,Yasuaki Saitoh et al.
Tetsuya Miyamoto et al.
d-Serine plays vital physiological roles in the functional regulation of the mammalian brain, where it is produced from l-serine by serine racemase and degraded by d-amino acid oxidase. In the present study, we identified a new d-serine met...
From molecular basis to clinical insights: a challenging future for the vitamin D endocrine system in colorectal cancer [0.03%]
从分子基础到临床见解：结直肠癌中维生素D内分泌系统的挑战未来
Fábio Pereira,Asunción Fernández-Barral,María Jesús Larriba et al.
Fábio Pereira et al.
Colorectal cancer (CRC) is one of the most life-threatening neoplasias in terms of incidence and mortality worldwide. Vitamin D deficiency has been associated with an increased risk of CRC. 1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the most...
Corrigendum [0.03%]
勘误表
Published Erratum
The FEBS journal. 2024 Jan;291(2):392-393. DOI:10.1111/febs.16942 2024
Substrate profiling of the metalloproteinase ovastacin uncovers specific enzyme-substrate interactions and discloses fertilization-relevant substrates [0.03%]
卵泡素金属蛋白酶底物的基质剖析发现其特异的酶-底物相互作用并揭示了与受精相关的潜在底物
Matthias Felten,Ute Distler,Nele von Wiegen et al.
Matthias Felten et al.
The metalloproteinase ovastacin is released by the mammalian egg upon fertilization and cleaves a distinct peptide bond in zona pellucida protein 2 (ZP2), a component of the enveloping extracellular matrix. This limited proteolysis causes z...
Simultaneous structural replacement of the sphingoid long-chain base and sterol in budding yeast [0.03%]
同时在芽殖酵母中用鞘氨醇长链碱和固醇进行结构替代
Yushi Kono,Yohei Ishibashi,Shizuka Fukuda et al.
Yushi Kono et al.
The basic structures of membrane lipids that compose biomembranes differ among species; i.e., in mammals, the primary structure of long-chain base (LCB), the common backbone of ceramides and complex sphingolipids, is sphingosine, whereas, i...
Coenzyme-binding pathway on glutamate dehydrogenase suggested from multiple-binding sites visualized by cryo-electron microscopy [0.03%]
低温电子显微镜观察到的多结合位点暗示谷氨酸脱氢酶上的辅因子结合途径
Taiki Wakabayashi,Mao Oide,Takayuki Kato et al.
Taiki Wakabayashi et al.
The structure of hexameric glutamate dehydrogenase (GDH) in the presence of the coenzyme nicotinamide adenine dinucleotide phosphate (NADP) was visualized using cryogenic transmission electron microscopy to investigate the ligand-binding pa...