The regulation of liquid-liquid phase separated condensates containing nucleic acids [0.03%]
含核酸的液滴相分离凝集物的调控
Zhuojun Dai,Xiaorong Yang
Zhuojun Dai
Liquid-liquid phase separation (LLPS) has been recognized as a universal biological phenomenon. It plays an important role in life activities. LLPS is induced by weak interactions between intrinsically disordered regions or low complex doma...
An innate immune sensor wandering around - NOD1 promotes cell migration via non-canonical signaling [0.03%]
游走的先天免疫传感器-NOD1通过非经典信号通路促进细胞迁移
Ingo Schmitz,Sabrina Mühlen
Ingo Schmitz
NOD1 is a cytosolic immune receptor well known for recognizing intracellular bacteria and inducing innate immune responses. Upon ligand binding, it usually forms a complex with the serine/threonine kinase RIPK2 to activate the transcription...
Functional and structural properties of pyridoxal reductase (PdxI) from Escherichia coli: a pivotal enzyme in the vitamin B6 salvage pathway [0.03%]
大肠杆菌吡哆醛还原酶（PdxI）的功能和结构特征——维生素B6补救途径中的一个关键酶
Angela Tramonti,Akua K Donkor,Alessia Parroni et al.
Angela Tramonti et al.
Pyridoxine 4-dehydrogenase (PdxI), a NADPH-dependent pyridoxal reductase, is one of the key players in the Escherichia coli pyridoxal 5'-phosphate (PLP) salvage pathway. This enzyme, which catalyses the reduction of pyridoxal into pyridoxin...
Seek and you shall find-news on the quest for novel PET-degrading enzymes [0.03%]
寻寻觅觅，终能发现——关于寻找新型PET降解酶的研究报道
Anna Faber,Georg Fritz
Anna Faber
Plastic-degrading enzymes hold immense potential for eco-friendly recycling methods. However, the catalytic rates of current enzymes do not stack up against the mammoth task of degrading millions of tons of plastic waste per year. In the qu...
Synaptotagmin-7 mediates cardiac hypertrophy by targeting autophagy [0.03%]
synaptotagmin-7通过调控自噬介导心室肥厚
Teng Sun,Yu Han,Jia-Lei Li et al.
Teng Sun et al.
Sustained cardiac hypertrophy damages the heart and weakens cardiac function, often leading to heart failure and even death. Pathological cardiac hypertrophy has become a central therapeutic target for many heart diseases including heart fa...
Anasuya Moitra,Vitasta Tiku,Doron Rapaport
Anasuya Moitra
Mitochondrial outer membrane β-barrel proteins are encoded in the nucleus, translated in the cytosol and then targeted to and imported into the respective organelles. Detailed studies have uncovered the mechanisms involved in the import of...
Tenzin Deyang,Md Awaise Iqbal Baig,Phurbu Dolkar et al.
Tenzin Deyang et al.
Sleep disorders are becoming increasingly common, and their distinct effects on physical and mental health require elaborate investigation. Gut dysbiosis (GD) has been reported in sleep-related disorders, but sleep apnoea is of particular s...
Yoshinori Takeuchi,Yuki Murayama,Yuichi Aita et al.
Yoshinori Takeuchi et al.
During periods of fasting, the body undergoes a metabolic shift from carbohydrate utilization to the use of fats and ketones as an energy source, as well as the inhibition of de novo lipogenesis and the initiation of gluconeogenesis in the ...
Novel tetrahydrofolate-dependent d-serine dehydratase activity of serine hydroxymethyltransferases [0.03%]
丝氨酸羟甲基转移酶的新四氢叶酸依赖性的d-丝氨酸脱水酶活性
Tetsuya Miyamoto,Shinya Fushinobu,Yasuaki Saitoh et al.
Tetsuya Miyamoto et al.
d-Serine plays vital physiological roles in the functional regulation of the mammalian brain, where it is produced from l-serine by serine racemase and degraded by d-amino acid oxidase. In the present study, we identified a new d-serine met...
From molecular basis to clinical insights: a challenging future for the vitamin D endocrine system in colorectal cancer [0.03%]
从分子基础到临床见解：结直肠癌中维生素D内分泌系统的挑战未来
Fábio Pereira,Asunción Fernández-Barral,María Jesús Larriba et al.
Fábio Pereira et al.
Colorectal cancer (CRC) is one of the most life-threatening neoplasias in terms of incidence and mortality worldwide. Vitamin D deficiency has been associated with an increased risk of CRC. 1α,25-Dihydroxyvitamin D3 [1,25(OH)2D3], the most...