Characterisation of a cold-adapted, thermostable glucokinase from psychrophilic Pseudoalteromonas sp. AS-131 reveals how the enzyme achieves high thermal stability without loss of cold adaptation [0.03%]
来自嗜冷的Pseudoalteromonas sp. AS-131嗜冷且热稳定的葡萄糖激酶的特性揭示了该酶如何在不失去嗜冷适应性的情况下实现高热稳定性
Akane Yato,Yuki Kato,Fuyuko Hayashi et al.
Akane Yato et al.
Microorganisms living in cold environments such as the Antarctic and deep sea usually possess cold-adapted enzymes, which are known to have high catalytic efficiency and low stability owing to their flexible structures. Research on cold-ada...
Current advances in recombinant porcine reproductive and respiratory syndrome virus vaccines in plants [0.03%]
植物中重组猪繁殖与呼吸综合征病毒疫苗的最新进展
Marco Costantini,Marcello Donini
Marco Costantini
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious RNA virus that severely affects swine herds, causing respiratory and reproductive disorders with major global economic impact. Current first-generation vacci...
Yahong Xu,Jingping Liu
Yahong Xu
Although macrophages (MФs) are vital regulators of acute kidney injury (AKI), their diverse roles in renal injury and repair remain elusive. Li et al. leveraged single-cell RNA sequencing to dissect MФ dynamics at different stages of cisp...
Julija Hmeljak
Julija Hmeljak
We highlight original articles published in The FEBS Journal in 2023 and 2024 that members of our Editorial Board deemed particularly notable. The papers discussed here received nominations based on their scientific excellence, timeliness a...
CcdA chaperones CcdB against irreversible misfolding and aggregation via a cotranslational folding mechanism [0.03%]
CcdA通过共翻译折叠机制对CcdB进行分子伴侣作用以防止其不可逆错误折叠和聚集
Priyanka Bajaj,Pehu Kohli,Raghavan Varadarajan
Priyanka Bajaj
Cotranslational subunit assembly is thought to be a prominent feature throughout the proteome, but, in bacteria, there are only a limited number of experimentally confirmed examples and most involve the addition of extraneous tag sequences ...
Functional divergence of protein kinase A regulatory subunit Iβ variants: the importance of N3A motifs in PKA regulation [0.03%]
蛋白激酶A调节亚基Iβ变异体的功能分化：N3A基序在PKA调控中的重要性
Maximilian Wallbott,Jui-Hung Weng,Valeria Pane et al.
Maximilian Wallbott et al.
Protein kinase A (PKA) regulatory subunit Iβ (RIβ) plays a crucial role in modulating PKA activity through its interaction with the catalytic (C) subunit. Recent studies have identified two variants of RIβ that have not been distinguishe...
RNF13 is a previously undescribed interactor of iduronate 2-sulfatase that modifies its glycosylation and maturation [0.03%]
RING指蛋白13(RNF13)通过修饰其糖基化和成熟作用于Iduraonte 2-硫酸酯酶的新相互作用蛋白质
Valérie C Cabana,Antoine Y Bouchard,Audrey M Sénécal et al.
Valérie C Cabana et al.
Mucopolysaccharidosis type II, also known as Hunter syndrome, is a rare and fatal disease caused by mutations in the iduronate 2-sulfatase (IDS) encoding gene. Enzymatically inactive IDS variants lead to pathological accumulation of glycosa...
3'UTR variants of ALS-linked RNAs modify subcellular and cellular phenotypes [0.03%]
ALS相关RNA的3'UTR变异体可改变亚细胞和细胞表型
Melis Savasan-Sogut,Danae Campos-Melo,Michael J Strong
Melis Savasan-Sogut
While most human genes express mRNA 3'untranslated region (3'UTR) variants of different lengths, their impact on cell physiology and disease remains largely unknown. Here, we studied 3'UTR length heterogeneity in amyotrophic lateral scleros...
Comparative analysis of metabolic and functional cardiac alterations in diet- and genetically induced mouse models of cardiac dysfunction [0.03%]
饮食和遗传诱导的小鼠心功能障碍心脏代谢和功能改变的比较分析
Christiane Ott,Patricia Baumgarten,Thorsten Henning et al.
Christiane Ott et al.
Cardiac metabolism is highly adaptive, and distinct maladaptive remodeling processes may contribute to the development of cardiac dysfunction. Here, we compared the metabolic, structural, and functional adaptations of two murine models: C57...
EHD4 and ASAP2 are critical negative regulators of the claudin-5-based endothelial barrier [0.03%]
EHD4和ASAP2是基于Claudin-5的内皮屏障的关键负调节因子
Yosuke Hashimoto,Gergő Porkoláb,Natalie Hudson et al.
Yosuke Hashimoto et al.
Disruption to barriers of the central nervous system (CNS) has been shown in both prime and drive pathologies observed across numerous neurological and ophthalmological conditions. These barriers are composed of well evolved endothelial tig...