Selective targeting of cortactin tandem repeat acetylation by human lysine deacetylases [0.03%]
人类赖氨酸脱乙酰酶有选择性地特异靶向皮层素N末端串联重复序列的乙酰化位点
Jan Komarek,Miroslava Vosahlikova,Zsofia Kutil et al.
Jan Komarek et al.
Lysine acetylation within the tandem repeat region of cortactin (CTTN) regulates its actin-binding function and has been linked to cancer cell migration and neuronal development. While several lysine deacetylases (KDACs) have been implicate...
ADAMTS proteases in extracellular vesicles: emerging mediators of extracellular matrix dynamics and disease progression [0.03%]
细胞外囊泡中的ADAMTS蛋白酶：细胞外基质动态和疾病进展的新兴介质
Carlos Peris-Torres,Juan Carlos Rodríguez-Manzaneque
Carlos Peris-Torres
Recent advances highlight extracellular vesicles (EVs) as key mediators of intercellular communication, carrying a complex cargo that includes extracellular matrix (ECM) components and associated modulators. Among them, ADAMTS proteases are...
Kinetic and structural characterisation of domain-specific angiotensin I-converting enzyme inhibition by captopril, rentiapril and zofenoprilat [0.03%]
卡托普利、伦替派唑和佐芬普利拉特对血管紧张素I转化酶结构域的特异性动力学及结构特征研究
Kyle S Gregory,Vinasha Ramasamy,Edward D Sturrock et al.
Kyle S Gregory et al.
Angiotensin I-converting enzyme (ACE) is a zinc-dependent dipeptidyl carboxypeptidase involved in blood pressure regulation through proteolysis of angiotensin I (Ang-I) into the potent vasoconstrictor, angiotensin II (Ang-II). Inhibition of...
Shikimate pathway disruption in yeast induces metabolite self-assembly into toxic aggregates [0.03%]
破坏酵母虾青素合成途径致使代谢物自装形成毒性聚集物
Hanaa Adsi,Myra Gartner,Claris Simovich et al.
Hanaa Adsi et al.
The shikimate pathway in Saccharomyces cerevisiae is pivotal for the biosynthesis of aromatic amino acids, which are essential for protein synthesis and cellular homeostasis. Here, we investigated the regulatory mechanisms within this pathw...
Nemo-like kinase modulates glucocorticoid-induced erythroid progenitor differentiation by regulating stability of the glucocorticoid receptor [0.03%]
宁摸似激酶通过调节糖皮质激素受体稳定性调控糖皮质激素诱导的红系祖细胞分化
Swati Srivastava,Sangita Chowdhury,Vishal Upadhyay et al.
Swati Srivastava et al.
Glucocorticoid receptor (GR) is a critical regulator of erythroid progenitor proliferation, while Nemo-like kinase (NLK) is reported to be hyperactivated in Diamond-Blackfan anemia (DBA), suggesting a possible cross talk. Here, we demonstra...
Spatial control of Keratin 8 phosphorylation by Aurora B facilitates cytokinesis in cancer cells of epithelial origin [0.03%]
染色体着丝点激酶B调控角蛋白磷酸化以促进上皮来源癌细胞的胞质分裂
Busra Harmanda,Halenur Ayaydin,Xenia Waide et al.
Busra Harmanda et al.
Keratins assemble into mechanically resilient polymers that physically stabilize epithelial cells. When epithelial cells divide, keratin polymers must be severed to allow cell separation during cytokinesis. Phosphorylation has been implicat...
Women didn't ruin the scientific workforce: we made it better, for everyone! [0.03%]
是女性毁了科研职场吗？恰恰相反！我们让科学界变得更好了
Kirsten C Sadler
Kirsten C Sadler
In this Editorial, Editorial Board member Kirsten C. Sadler responds to two recent opinion pieces discussing the effects of increased representation of women in science. This Editorial discusses her own experiences and views as a prominent ...
Editorial
The FEBS journal. 2026 Feb 2. DOI:10.1111/febs.70435 2026
Molecular chaperones and proteostasis regulation during cytosolic translation [0.03%]
细胞翻译过程中分子伴侣和蛋白质稳态的调节
Ulrike Topf
Ulrike Topf
Molecular chaperones ensure that proteins attain their mature state by assisting in proper folding, preventing aggregation, refolding misfolded proteins, and targeting irreparably misfolded proteins for degradation. This comprehensive role ...
Concentration-dependent cytoplasmic phase separation of TDP-43 drives aggregation and proteinopathy [0.03%]
浓度依赖性的TDP-43细胞质相分离促进凝集和蛋白病产生
Pauline Combe,Chloé Subecz,Gaïzka Le Goff et al.
Pauline Combe et al.
TDP-43 mislocalization and aggregation are common features of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). However, the mechanisms underlying the transition ...
Reframing fibrosis as a barrier to regeneration and gene delivery in muscular diseases [0.03%]
肌病再生和基因传递中的纤维化屏障效应再认识
Hasan Basri Kiliç,Y Çetin Kocaefe
Hasan Basri Kiliç
Gene replacement therapies for muscular dystrophies show promise in preclinical models but often fail in clinical settings. A major difference between animal models and human pathology is the extent of fibrosis observed. Progressive and irr...