Novel amino acid aminotransferases mediate the final steps in biosynthetic pathways of branched-chain and aromatic amino acids in the hyperthermophile Thermotoga maritima [0.03%]
新的氨基酸转氨酶介导超嗜热菌 Thermotoga maritima 分支链和芳香族氨基酸生物合成途径的最终步骤
Tetsuya Miyamoto,Shunya Abe,Yuki Hoshiyama et al.
Tetsuya Miyamoto et al.
The hyperthermophile Thermotoga maritima does not possess a typical branched-chain amino acid aminotransferase or aromatic amino acid aminotransferase, leaving the biosynthetic pathways of these amino acids unclear. In this study, we identi...
Targeting the microbiota-miRNA-protease axis: A new therapeutic avenue in melanoma [0.03%]
针对微生物群-miRNA-蛋白酶轴：黑色素瘤治疗的新途径
Elias N Katsoulieris,Paraskevi Ioannou,Nikolaos A Afratis
Elias N Katsoulieris
Modulation of extracellular matrix (ECM) turnover is a critical prerequisite process underlying the onset of melanoma metastasis. ECM proteases are involved in the degradation of matrix components during ECM turnover, which is associated wi...
Bünyamin Akgül,Günnur Güler,Buket Sağlam et al.
Bünyamin Akgül et al.
Recent epitranscriptomic studies show that ribonucleic acids (RNAs) are coated with an array of chemical modifications that dictate their cellular fate. Genetic, biochemical, and genomic approaches have been employed to elucidate the molecu...
Limited roles of the miR-17-92 cluster in the regulation of T-cell apoptosis [0.03%]
miR-17-92簇调节T细胞凋亡的作用有限
Katharina Hoppe,Johannes Woelk,Julia Benz et al.
Katharina Hoppe et al.
The pro-apoptotic BCL-2-interacting mediator of cell death [BIM; also known as Bcl-2-like protein 11 (BCL2L11)] is a crucial regulator of programmed cell death in immune cells, with roles in T-cell development, homeostasis, and immune respo...
Ignazio Restivo,Julija Hmeljak
Ignazio Restivo
We are delighted to present a selection of original articles, curated by FEBS Junior Section member, Dr Ignazio Restivo. These articles were published in The FEBS Journal in 2024 and 2025, and cover molecular aspects of developmental biolog...
Toshiya Senda,Yoshihisa Hirota
Toshiya Senda
Rickets, a disorder of bone formation, was originally known as nutritional rickets due to vitamin D deficiency. Advances in science have since identified various genetic forms, typically involving loss-of-function mutations in vitamin D act...
A hidden property of the iron-sulfur protein in the mononuclear iron-bound state: species-dependent structural ordering induced by magnetic fields [0.03%]
单核铁结合态铁硫蛋白的隐秘性质：磁场诱导的种类依赖性结构有序化
Shigeki Arai,Shogo Soga,Mitsuhiro Hirai et al.
Shigeki Arai et al.
The iron-sulfur (Fe-S) cluster assembly homolog 1 (ISCA1) is a ubiquitous protein conserved in various organisms. Previous work has shown that a pigeon ISCA1 (clISCA1) forms columnar oligomers in the 2Fe-2S cluster-bound state, the length o...
Praja1 E3 ubiquitin ligase and the role it plays in neurodegeneration [0.03%]
Praja1 泛素连接酶在神经退行性疾病中的作用机制研究
Kazuhiko Watabe
Kazuhiko Watabe
Protein aggregation and transmission are hallmarks of neurodegenerative diseases. Praja1 E3 ubiquitin ligase has been shown to suppress the aggregation of causative proteins in amyotrophic lateral sclerosis, frontotemporal lobar degeneratio...
Detection of endogenous LINE-1 ORF2p and its potent reverse transcriptase activity in the MCF-7 breast cancer cell line [0.03%]
在MCF-7乳腺癌细胞系中检测内源性LINE-1ORF2蛋白及其强大的逆转录酶活性
Gopal Sarkar,Sujoy Kundu,Sulakshana P Mukherjee et al.
Gopal Sarkar et al.
Long interspersed element-1 (LINE-1 or L1) is actively jumping in humans, notably in germ cells, neurons, and certain types of cancer. An active L1 is ~6.0 kb in length and encodes two proteins, designated ORF1p and ORF2p. L1 RNA binds with...
Cryo-EM structure of N-glycosylated Pomacea canaliculata hemocyanin provides insights into its role in the immune response of gastropods [0.03%]
美洲大蠊血蓝蛋白的糖基化 cryo-em 结构为腹足类免疫反应中的作用提供了见解
Tabata Romina Brola,Ignacio Rafael Chiumiento,Santiago Ituarte et al.
Tabata Romina Brola et al.
Hemocyanins are multifunctional soluble proteins found in most mollusks and some arthropods that may turn into a phenoloxidase-like enzyme (PO) associated with innate immune functions. To expand the structural understanding of gastropod hem...