Current perspectives on KMT2A fusion proteins and menin inhibition in paediatric acute myeloid leukaemia [0.03%]
儿童急性髓系白血病中KMT2A融合蛋白和menin抑制的最新观点
Lydia Elaine Roets,Graeme Greenfield,Katrina Mairead Lappin
Lydia Elaine Roets
The therapeutic landscape of acute myeloid leukaemia (AML) has evolved beyond the classic '7 + 3'/DA regimen, through the approval and incorporation of targeted treatments in both front-line and relapsed/refractory settings. Indeed, the use...
The malate-aspartate shuttle supports thermogenic lipid mobilization in brown adipocytes [0.03%]
反丁烯二酸天冬氨转移通道能够促进褐色脂肪细胞产热生脂作用
Michaela Veliova,Caroline M Ferreira,Katrina P Montales et al.
Michaela Veliova et al.
Brown adipose tissue (BAT) plays a central role in thermogenesis by coupling fatty acid oxidation to heat production. Efficient BAT thermogenic activity requires enhanced glycolytic flux, which in turn depends on continuous regeneration of ...
Variability in intracellular localization of D-amino acid oxidase in choroid plexus epithelial cells [0.03%]
脑室脉络丛上皮细胞内D型氨基酸氧化酶定位的差异性
Koji Ono,Yuji Shishido,Toshiyuki Yamagishi et al.
Koji Ono et al.
D-amino acid oxidase (DAO; also abbreviated as DAAO) in the brain is primarily expressed in glial cells of the cerebellum and brainstem. In glial cells, DAO metabolizes D-serine, which acts as a co-agonist and regulator of glutamate recepto...
Intrinsic cellular heterogeneity directs divergent epithelial-to-mesenchymal transition outcomes [0.03%]
固有的细胞异质性决定了不同的上皮间质转化结果
Esin Ozkuru Sekeroglu,Şeyma N Yıldız,Seray Yetkin et al.
Esin Ozkuru Sekeroglu et al.
Epithelial-to-mesenchymal transition (EMT) is a fundamental process in development and disease; however, its study is often complicated by the intrinsic heterogeneity of commonly used epithelial cell models. Here, we show that pre-existing ...
Altaira D Dearborn,Alan T Remaley,Joseph Marcotrigiano
Altaira D Dearborn
Cardiovascular disease is a major cause of human morbidity and mortality. Drug strategies for the prevention of the disease are largely centered on the interaction of low-density lipoprotein receptor (LDLR) with the apolipoprotein B-100 (ap...
H2-dependent modulation of tetrahydromethanopterin S-methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei [0.03%]
甲烷八叠球菌中MtrR通过辅酶H2调节四氢甲基营养素S-甲基转移酶(Mtr复合体)的活性
Tim Habenicht,Bjarne Hastedt,Liam Cassidy et al.
Tim Habenicht et al.
Small open reading frame (sORF)-encoded proteins, with less than 100 amino acids, have attracted increasing attention over the past decade after being overlooked due to limitations in classical methodologies. For the mesophilic archaeal mod...
Structural characterization of endogenous microprotein EMBOW reveals an alternative MRT motif for WDR5-interacting site recognition [0.03%]
结构表征内源性微蛋白EMBOW揭示了与WDR5相互作用位点识别的MRT基序替代形式
Yang Yang,Yan Pan,Shuting Zhang et al.
Yang Yang et al.
WD repeat-containing protein 5 (WDR5) is a conserved chromatin regulator that engages numerous binding partners via a central arginine-binding pocket known as the WDR5-interacting (WIN) site. Endogenous microprotein binder of WDR5 (EMBOW, a...
Deciphering the structural insights and concentration-dependent dimerisation of endo-β-1,4-xylanase (AcXyn30B_12) from Acetivibrio clariflavus using SAXS and computational methods [0.03%]
基于小角X射线散射和计算方法解析木聚糖内切酶（AcXyn30B_12）的结构信息及浓度依赖性二聚化现象
Bipasha Choudhury,Arun Goyal
Bipasha Choudhury
Structure of full-length thermophilic multi-modular endo-β-1,4-xylanase, AcXyn30B_12 from Acetivibrio clariflavus DSM 19732 was determined by computational analysis and SAXS studies. AcXyn30B_12 comprised N-terminal glycoside hydrolase fam...
Correction to "The chromatin remodeling protein INO80 contributes to the removal of H2A.Z at the p53-binding site of the p21 gene in response to doxorubicin" [0.03%]
关于“染色质重塑蛋白INO80通过响应多柔比星在p53结合位点去除组蛋白H2A.Z对p21基因的表达有贡献”的校正
Published Erratum
The FEBS journal. 2026 Feb 11. DOI:10.1111/febs.70448 2026